Crystal form of flomoxef sodium, preparation method, pharmaceutical composition and application
A technology of sodium fluoxefaclor and a composition, applied in the field of drug crystals, can solve the problems of inability to be removed by drying, no clear disclosure of the crystal form of sodium fluoxefate, and organic solvents affecting medicinal value, etc., and achieve the advantage of good stability Effect
Active Publication Date: 2020-05-22
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AI-Extracted Technical Summary
Problems solved by technology
The invention provides a crystal form of flomoxef sodium. An X-ray diffraction pattern of the crystal form comprises X-ray diffraction peaks as shown in the following 2[theta] angles: 5.2 +/-0.2 degrees and 16.2 +/-0.2 degrees. In addition, the invention also discloses a preparation method of the crystal form compound, a pharmaceutical composition and application of the crystal form compound and the pharmaceutical composition in preparation of anti-bacterial infection drugs. Compared with an amorphous product prepared by a freeze-drying process, the novel crystal form obtained by the preparation method disclosed by the invention has the advantages that the stability of the novel crystal form is obviously superior to that of the amorphous form, which means that the crystal form disclosed bythe invention has less degradation impurity generation and lower drug storage condition requirements within the validity period, and has a good medicinal use prospect.
Antibacterial agentsOrganic active ingredients +1
Chemical compoundFlomoxef +9
- Experimental program(11)
Description & Claims & Application Information
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