External traditional Chinese medicine composition for treating acne, and preparation method thereof

A composition and technology of traditional Chinese medicine, applied in the field of external Chinese medicine composition for treating acne and its preparation, can solve the problems of inconvenient use, unsatisfactory effective rate, loss of non-water-soluble components in the extraction process of active ingredients, etc., to achieve enhanced drug efficacy, Effects of increasing absorption and shortening the onset time

Inactive Publication Date: 2020-05-26
陶玉华
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, modern medicine mainly uses retinoic acid, antibiotics, hormones and other drugs for treatment, but there are certain drug resistance and adverse drug reactions, and the effective rate is not ideal
At present, there are a variety of traditional Chinese medicine external treatment products for acne treatment on the market. In terms of preparation process, most products adopt a single extraction method or si

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] The raw materials of the external Chinese medicine composition for treating acne are 30 parts of sophora flavescens, 30 parts of white fresh skin, 15 parts of centipede, 10 parts of Cortex Phellodendri, 3 parts of rhubarb and 6 parts of Daxueteng;

[0042] The preparation method comprises the following steps:

[0043] Prepare the raw materials according to the above-mentioned raw material composition ratio;

[0044] Soak the Sophora flavescens, Radix Cortex Radix, Cortex Vertex and Phellodendron Phellodendron in water for at least 2 hours, and then use water as a solvent to carry out extraction under normal pressure respectively to obtain extracts of Sophora Radix Sophorae Sophorae, Radix Cortex Cortex Radix and Radix Cortex Cortex and Phellodendron Phellodendri extract; the mass ratio of the mass of Sophora flavescens, white fresh bark, Baibu or Cortex Phellodendri to water is 1:8, and a total of 2 extractions are carried out, and the liquids after the two extractions ...

Embodiment 2

[0051] The raw material components of the external Chinese medicine composition for treating acne are 20 parts of Sophora flavescens, 40 parts of Radix Cortex, 10 parts of Baibu, 12 parts of Cortex Phellodendri, 2 parts of Rhubarb, and 8 parts of Daxueteng;

[0052] Preparation method is with embodiment 1, and difference is:

[0053] (1) Carry out negative pressure extraction respectively, the mass ratio of the mass of Sophora flavescens, white fresh cortex, hundred or Phellodendron cortex to water is 1:9; each extraction time is 1.0 to 1.5 hours, and the working pressure during extraction is -0.06 to -0.08 MPa;

[0054] (2) The quality of the concentrate is 22% of the total mass of the purified filtrate;

[0055] (3) The addition of antiseptic is 0.01% of the total mass of the mixed material; the addition of the moisturizing agent is 3% of the total mass of the mixed material; first disperse and homogenize with a stirring speed of 3000 rpm, and then use a stirring speed of 7...

Embodiment 3

[0057]The raw material components of the external Chinese medicine composition for treating acne are 40 parts of Sophora flavescens, 20 parts of Baixianpi, 20 parts of Baibu, 6 parts of Cortex Phellodendri, 5 parts of Rhubarb, and 3 parts of Daxueteng;

[0058] Preparation method is with embodiment 1, and difference is:

[0059] (1) Ultrasonic extraction is carried out respectively, the mass ratio of Sophora flavescens, white fresh cortex, Baibu or Cortex Phellodendri to water is 1:9, and the extraction time is 25-35 minutes each time; Cortex Phellodendron is first crushed to a particle size below 5mm;

[0060] (2) The quality of the concentrate is 24% of the total mass of the purified filtrate;

[0061] (3) The addition of antiseptic is 0.01% of the total mass of the mixed material; the addition of the moisturizing agent is 3% of the total mass of the mixed material; first disperse and homogenize with a stirring speed of 4000 rpm, and then use a stirring speed of 8000 rpm T...

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PUM

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Abstract

The invention discloses an external traditional Chinese medicine composition for treating acne, and a preparation method thereof. The external traditional Chinese medicine composition is prepared from, by weight, 10-50 parts of radix sophorae flavescentis, 10-50 parts of cortex dictamni, 5-30 parts of radix stemonae, 5-15 parts of cortex phellodendri, 1-8 parts of radix et rhizoma rhei and 1-10 parts of caulis sargentodoxae. The method comprises the following steps: (1) preparing raw materials; (2) soaking the radix sophorae flavescentis, cortex dictamni, radix stemonae and cortex phellodendriin water, performing extraction to obtain radix sophorae flavescentis extract, cortex dictamni extract, radix stemonae extract and cortex phellodendri extract; (3) mixing and filtering the radix sophorae flavescentis extract, the cortex dictamni extract, the radix stemonae extract and the cortex phellodendri extract to obtain a purified filtrate; (4) performing evaporative concentration; (5) drying the radix et rhizoma rhei and caulis sargentodoxae, grinding, and carrying out ultrafine grinding; and (6) putting the mixed powder into the above obtained concentrate, adding a preservative and ahumectants, and dispersing, homogenizing, shearing and refining the mixed material by adopting a homogenizing and emulsifying machine to prepare a paste. The production efficiency can be effectively improved, loss of effective components of the medicines is reduced, and the medicine effect is enhanced; and the product is convenient to carry and use, and has a good market prospect.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and relates to an external Chinese medicinal composition for treating acne and a preparation method thereof. Background technique [0002] Acne is a common chronic inflammatory skin disease that mainly occurs in the pilosebaceous unit of the face of adolescents. Pleomorphic skin lesions such as nodules are mainly found on the face, back, chest and other parts rich in sebaceous glands. The occurrence of acne is mainly related to factors such as excessive sebum secretion, blockage of pilosebaceous gland ducts, bacterial infection, and inflammatory response; after puberty, the level of androgen in the human body increases, and the sebaceous glands develop vigorously and produce a large amount of sebum. Abnormal keratinization of the pilosebaceous duct will cause duct blockage, sebum discharge obstruction, and then form keratin plugs, that is, micropowders. A variety of microor...

Claims

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Application Information

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IPC IPC(8): A61K36/904A61K9/06A61P17/10
CPCA61K9/0014A61K9/06A61K36/185A61K36/489A61K36/708A61K36/75A61K36/756A61K36/904A61K47/14A61K2236/15A61K2236/331A61K2236/39A61P17/10A61K2300/00
Inventor 陶玉华
Owner 陶玉华
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