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Coated sodium butyrate as well as preparation method and application thereof

A technology of coating and coating layer, which is applied in the field of mixed veterinary drug additive preparations, coated Riduran and its preparation, can solve problems such as difficulty in reaching the cecum and colon, difficulty in ensuring diarrhea rate, and difficulty in ensuring the release of sodium butyrate , to achieve the effect of improving slow weight gain and realizing the precise positioning of the intestinal tract

Pending Publication Date: 2020-06-05
宋凤香
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, because the residence time of the feed in the colon of pigs is only about 10 hours, the release rate in the colon is relatively slow, and most of them cannot be fully utilized.
[0009] To sum up, the main disadvantages of the existing technology are: most of the sodium butyrate is absorbed by the stomach and small intestine, and it is difficult to reach the cecum and colon; Released in the medium, resulting in slow average daily weight gain of piglets, high feed meat ratio, and the diarrhea rate is difficult to guarantee

Method used

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  • Coated sodium butyrate as well as preparation method and application thereof
  • Coated sodium butyrate as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] First pass 30 parts by weight of sodium butyrate and 30 parts by weight of microcrystalline cellulose blank core through a 100-mesh sieve, mix well and then add 1 part by weight of HPMC K15M soft aqueous solution as a binder, using a sieve plate with an aperture of 0.6mm Extruded into strips, the extrusion speed is 30rpm; then placed in a spheronizer, set the spheronization speed to 60rpm; the spheronization time is 3min, to obtain spherical sodium butyrate drug-loaded pellet cores. The latter is dried at 50° C., and 20-30 meshes of sodium butyrate-loaded pill cores are obtained by sieving for coating. Ethyl cellulose (average molecular weight Mn is 18260; ethoxyl content is 48.8wt%) and HPMC E5 are made aqueous dispersion liquid according to the weight ratio of 1: 0.10, adjust ethyl cellulose content to be 10wt%, obtain ethyl cellulose Cellulose coating solution. The sodium butyrate drug-loaded pellet core was placed in a fluidized bed coating equipment for bottom spr...

Embodiment 2

[0051] Other conditions are the same as in Example 1, but the weight of the ethylcellulose coating layer is adjusted to be 3.9wt%; the weight of the acrylic resin coating layer is 60.1wt%; and the weight ratio of ethylcellulose and HPMC E5 is 1: 0.081 .

Embodiment 3

[0053] Other conditions are the same as in Example 1, but the weight of the ethylcellulose coating layer is adjusted to be 6.1wt%; the weight of the acrylic resin coating layer is 55.2wt%; and the weight ratio of ethylcellulose and HPMC E5 is 1: 0.124 .

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Abstract

The invention discloses coated sodium butyrate which comprises a sodium butyrate medicine carrying pill core, an ethyecellulose coating layer and an acrylic resin coating layer from inside to outside,wherein acrylic resin is selected from acid-insoluble acrylic resin. The coated sodium butyrate both achieves precise positioning in an intestine and ensures that most sodium butyrate is released inceca and colons; and in addition, technical problems that a piglet is slow in average daily weight gain, the material to meat ratio is high and the diarrhea rate is high can be alleviated.

Description

technical field [0001] The invention belongs to the technical field of veterinary drug additives, and relates to a mixed veterinary drug additive preparation, in particular to a coated rituximab and its preparation method and application. Background technique [0002] In recent years, my country's pig industry is facing many serious problems, including rising feed costs, African swine fever, increasingly stringent environmental protection policies, roller coaster fluctuations in pork prices, and downgraded market consumption levels. Pig raising enterprises and feed production enterprises are facing a new round of industry reshuffle. In this round of reshuffle, large-scale farming has become the general trend. [0003] Under the conditions of large-scale breeding, the production rhythm of pig farming enterprises is more compact, and the batch production mode of all in and all out is implemented. The early weaning technology of piglets has been popularized and applied on a l...

Claims

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Application Information

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IPC IPC(8): A61K9/36A61K9/30A61K31/19A61K47/38A61K47/32A61P39/00A61P1/12
CPCA61K9/284A61K9/2866A61K9/2886A61K31/19A61P1/12A61P39/00
Inventor 宋凤香吕延飞阮丽青徐洪星王琰张吉猛李艳霞陆桂英王伟王明月白耀国魏一华
Owner 宋凤香
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