Method for preparing taurine from sodium isethionate

A technology of sodium isethionate and taurine, applied in the direction of sulfonic acid preparation, sulfonate preparation, chemical instruments and methods, etc., can solve the problem of difficult catalyst recovery, high energy consumption cost, and homogeneous catalysts that cannot be recycled and applied mechanically and other problems, to achieve the effect of being suitable for industrial production, shortening the reaction time, and improving the electrophilic characteristics

Active Publication Date: 2020-06-12
WANHUA CHEM GRP CO LTD
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Problems solved by technology

[0005] The reaction of sodium isethionate and liquid ammonia to prepare sodium taurate is a key synthesis step of the ethylene oxide method. In the initial research, since no catalyst was added, it required high temperature of 200-280°C and high pressure of 14-21MPa. Reaction conditions, so the energy cost of the reaction process is high, and there are certain safety risks
[0006] Chinese patent CN107056659A discloses a method of selecting alkali metal hydroxide or carbonate as a homogeneous catalyst in the ammonolysis reaction process. cannot be recycled
[0008] Chinese patent CN105732440A discloses that in the ammonolysis reaction process containing mother liquor, alkali metal hydroxides, alkali metal carbonates (includ

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  • Method for preparing taurine from sodium isethionate

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Effect test

Embodiment 1

[0037] 696g of sodium isethionate solution (10wt%) was placed in a 1L high-pressure reactor, and 0.209g of Zr 2 MoO 4 (PO 4 ) 2 Catalyst, feed 160g liquid ammonia subsequently, make the molar ratio of liquid ammonia and sodium isethionate be 20, the temperature of reaction system is raised to 120 ℃, system pressure is 6MPa, reaction 30min, the sodium taurate obtained by ammonolysis reaction Yield 92.0%.

[0038]The reaction liquid was distilled and concentrated under reduced pressure at 75°C and -0.07MPa, and the concentration of sodium taurate was increased to 35wt%. At 45°C, concentrated sulfuric acid was added to adjust the pH of the system to 6, and then cooled to 15°C for crystallization. The one-way yield of taurine is 75.0%, and the mother liquor can be applied to the ammonolysis reaction again, and the total yield of taurine is 94.0%.

Embodiment 2

[0040] 740g of sodium isethionate solution (6wt%) was placed in a 1L high-pressure reactor, and 0.222g of Zr 2 MoO 4 (PO 4 ) 2 Catalyst, feed 81.6g liquid ammonia subsequently, make the molar ratio of liquid ammonia and sodium isethionate be 16, the reaction system is heated to 100 ℃, system pressure is 7MPa, reaction 55min, the taurine that this step reaction can obtain Sodium acid yield 93%.

[0041] The reaction solution was distilled and concentrated under reduced pressure at 78°C and -0.067MPa, and the concentration of sodium taurate was increased to 33wt%. At 85°C, concentrated sulfuric acid was added to adjust the pH of the system to 9, and then cooled to 30°C for crystallization. The one-way yield of taurine is 72.0%, and the mother liquor can be applied to the ammonolysis reaction again, and the total yield of taurine is 92.1%.

Embodiment 3

[0043] 724g of sodium isethionate solution (12wt%) was placed in a 1L high-pressure reactor, and 0.608g of ZrMo 2 o 8 Catalyst, feed 110g liquid ammonia subsequently, make the molar ratio of liquid ammonia and sodium isethionate be 11, the reaction system is heated to 140 ℃, system pressure is 4MPa, reaction 80min, the taurine that this step reaction can obtain The sodium yield was 91.0%.

[0044] The reaction solution was distilled and concentrated under reduced pressure at 85°C and -0.06MPa, and the concentration of sodium taurate was increased to 50wt%. At 60°C, concentrated sulfuric acid was added to adjust the pH of the system to 7, and then cooled to 35°C for crystallization. The one-way yield of taurine is 73.5%, and the mother liquor can be applied to the ammonolysis reaction again, and the total yield of taurine is 96.0%.

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Abstract

The invention provides a method for preparing taurine from sodium isethionate. The method comprises the following steps: catalyzing the reaction between sodium isethionate and ammonia by using a heterogeneous catalyst to generate sodium taurate, then neutralizing, crystallizing, separating and the like to obtain the finished product taurine, wherein the heterogeneous catalyst is one or more of Zr2MoO4 (PO4) 2, ZrMo2O8 or MoO3. Compared with a traditional basic catalyst, the process has the advantages that the temperature and the pressure of the sodium hydroxyethyl sulfonate ammonolysis reaction can be remarkably reduced, the reaction time is shortened, and the adopted catalyst is easy to separate and recover and is suitable for industrial production.

Description

technical field [0001] The invention relates to a method for preparing taurine from sodium isethionate. Background technique [0002] The chemical name of taurine is 2-aminoethanesulfonic acid, which is an essential non-protein amino acid for the human body and exists in almost all organs of humans and mammals in free form. Since taurine was first discovered in ox bile, it is also known as taurine and ox bile. The role of taurine is different from that of other amino acids. It is not an essential amino acid for protein composition, but it is essential in the body, similar to a body regulatory factor. According to research, taurine can promote the growth and development of the nervous system, protect the brain and improve memory. It can also improve optic nerve conduction and visual function. It also has many important functions such as protecting the heart and preventing cardiovascular and cerebrovascular diseases. Taurine has high medicinal and medical value, is an import...

Claims

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Application Information

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IPC IPC(8): C07C303/32C07C303/22C07C303/44C07C309/14
CPCC07C303/32C07C303/22C07C303/44C07C309/14
Inventor 桂振友张静蔺海政郭斌钟子太孔令晓王文丰茂英李晶任娟陈来中张永振
Owner WANHUA CHEM GRP CO LTD
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