Preparation method and application of CHIR99021 and FGF1 nanoparticle combined myocardial tissue block
A technology of CHIR99021, 1. CHIR99021 is applied in the application field of treating ischemic heart disease in animals, and can solve problems such as the survival rate of small myocardial block transplantation
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[0047] The following examples are intended to further illustrate the present invention, rather than limit the present invention.
[0048] 1. Materials and methods
[0049] 1 Experimental materials
[0050] 1.1 Experimental animals
[0051] The experimental animals were 16-week-old female NOD-SCID mice with a body weight of 25-30 g, which were purchased from Jackson Company. Further husbandry and breeding were performed at the Animal Care Center, Department of Biomedical Engineering, University of Alabama at Birmingham.
[0052] 1.2 Experimental cells
[0053] hiPSCs are re-encoded from cardiac fibroblasts of human volunteers. Four transcription factors, Sox2, Klf4, Oct3 / 4 and C-Myc, are transfected into the above-mentioned cardiac fibroblasts by using lentivirus as a vector, and then re-encoded into hiPSCs.
[0054] 1.3 Main reagents, antibodies and instruments
[0055] List of experimental reagents
[0056]
[0057]
[0058] List of experimental antibodies (primary...
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