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Burn department biogel capable of accelerating wound healing and preparation method of burn department biogel

A technology of wound healing and biological gel, which is applied in medical science, bandages, etc., can solve problems such as single function, no antibacterial activity, and poor structural stability, and achieve improved antibacterial performance, excellent antibacterial performance, and stable thermodynamic structure. Effect

Inactive Publication Date: 2020-06-23
THE AFFILIATED HOSPITAL OF QINGDAO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the gel has the disadvantages of poor structural stability, no antibacterial activity and single function

Method used

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  • Burn department biogel capable of accelerating wound healing and preparation method of burn department biogel

Examples

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Effect test

preparation example Construction

[0028] The invention provides a method for preparing a burn biogel for accelerating wound healing, comprising the steps of:

[0029] S1, preparing a gelatinous bacterial nanocellulose wet film by fermentation culture, placing the bacterial nanocellulose wet film in deionized water, and performing high-speed shearing for 3 to 5 minutes to obtain a bacterial nanocellulose slurry with a predetermined mass concentration; The bacterial nanocellulose slurry is protected from light, and a predetermined amount of sodium periodate is added to perform an oxidation reaction at 35-45°C for 12-18 hours. After the reaction is completed, suction filtration, washing and freeze-drying are performed to prepare Modified bacterial nanocellulose;

[0030] S2, adding deionized water to the modified bacterial nanocellulose prepared in step S1 and homogenizing at a high speed to prepare a modified bacterial nanocellulose dispersion with a predetermined mass concentration; the modified bacterial nanoc...

Embodiment 1

[0041] A method for preparing a biogel for accelerating wound healing, comprising the steps of:

[0042] S1, inoculate the activated bacteria into the liquid fermentation medium, and culture it statically at 30°C for 10 days to prepare the bacterial nanocellulose membrane, take out the bacterial nanocellulose membrane, wash it with deionized water, and immerse it in 1% NaOH The solution was treated at 80°C for 4 hours, repeated several times to remove the remaining bacteria and culture medium, washed with deionized water to neutrality, and then sterilized at 121°C for 20 minutes to obtain a white translucent gel-like bacterial nanocellulose wet film ; The bacterial nanocellulose wet film is placed in deionized water, and high-speed shearing is carried out for 3 to 5 minutes to obtain a bacterial nanocellulose slurry with a mass concentration of 1.2wt%; the bacterial nanocellulose slurry is protected from light, Add sodium periodate and carry out oxidation reaction at 40° C. fo...

Embodiment 2-5

[0051] The difference from Example 1 is that the mass ratio of collagen to modified bacterial nanocellulose is set differently, and the mass ratio of modified bacterial nanocellulose to sodium alginate is set differently, and other steps are the same as in Example 1. No more details are given here, and the parameter settings are shown in Table 1.

[0052] Example M (collagen): M (modified bacterial nanocellulose) M (sodium alginate): M (modified bacterial nanocellulose) Example 1 2：1 4：1 Example 2 1：1 4：1 Example 3 3：1 4：1 Example 4 2：1 3：1 Example 5 2：1 6：1

[0053] In the present invention, the amino group in the collagen and the aldehyde group of the modified bacterial nanocellulose undergo a Schiff base reaction, and as the mass ratio of the collagen to the modified bacterial nanocellulose increases, the modified bacterial nanocellulose aldehyde group The consumption rate of the cellulose presents a trend of first increas...

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Abstract

The invention provides burn department biogel capable of accelerating wound healing and a preparation method of the burn department biogel. The preparation method comprises the following steps: firstly, carrying out oxidation reaction on bacterial nanocellulose by adopting sodium periodate to prepare modified bacterial nanocellulose; then, dispersing the modified bacterial nano-cellulose into water to prepare modified bacterial nano-cellulose dispersion liquid, and mixing the modified bacterial nano-cellulose dispersion liquid with a sodium alginate solution to obtain mixed liquid; then, mixing and stirring the mixed solution and a collagen swelling solution, and then putting the mixture into a boric acid and calcium chloride mixed crosslinking aqueous solution to carry out crosslinking reaction, so as to prepare composite biogel; and finally, soaking the composite biogel in a polyhexamethylene hydrochloric acid solution to prepare the biogel for the burn department for accelerating wound healing. The burn department biogel for accelerating wound healing prepared by the invention has excellent stability and thermal reversible self-repairing performance, and also has excellent biocompatibility, water absorption swelling property and broad-spectrum antibacterial performance.

Description

technical field [0001] The invention relates to the technical field of medical dressings, in particular to a biological gel for burns that accelerates wound healing and a preparation method thereof. Background technique [0002] Burns are skin injuries caused by exposure to flames, hot liquids, steam, hot surfaces, electrical currents, and extremely acidic or alkaline chemicals. Burns destroy the skin barrier that maintains the internal environment and prevents pathogens from invading, coupled with the existence of a large amount of denatured necrotic tissue and the exudation of protein-rich body fluids, bacteria will multiply on the wound surface, causing sepsis with hematogenous infection. It is still one of the main causes of burn death, and the wound is the main source of burn infection. [0003] The most common complication in the care of skin burns is wound infection, which is accompanied by a large amount of exudate, resulting in the breakdown of various growth facto...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08J3/24C08J7/14C08J7/12C08L5/04C08L89/00C08L1/04C08K3/16C08K3/38A61L26/00C08B15/02
CPCA61L26/0004A61L26/0023A61L26/0033A61L26/0066A61L26/008A61L2300/10A61L2300/232A61L2300/404A61L2300/418C08B15/02C08J3/075C08J3/246C08J7/12C08J7/14C08J2305/04C08J2389/00C08J2401/04C08J2405/04C08J2489/00C08K3/38C08K2003/162C08L1/04C08L5/04C08L89/00
Inventor 张丙起
Owner THE AFFILIATED HOSPITAL OF QINGDAO UNIV
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