Mechanically adaptable bioactive ceramic armor and its preparation method

A bioactive ceramic and adaptive technology, applied in tissue regeneration, medical science, prosthesis, etc., can solve the problems of ignoring the adaptive adjustment of skull deformation and not being able to realize the bionic skull structure and functional process well

Active Publication Date: 2021-09-14
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] To sum up, the general tissue engineering scaffold materials ignore the adaptive adjustment effect of the sutures (Sharpey’s fibers) in the skull’s own structure on the skull deformation
Many scaffold materials cannot well realize the bionic skull structure and functionalization process

Method used

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  • Mechanically adaptable bioactive ceramic armor and its preparation method

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] (1) dissolving 1.00g of chitosan in an acetic acid solution with a volume fraction of 2%, and magnetic stirring for 30min under a water bath condition of 37° C., to obtain a chitosan acid solution;

[0036] (2) Add 3mL each of 2mol / L soluble calcium salt solution and 1.2mol / L soluble phosphate solution to the mixed solution of step (1) successively with a time interval of 30min; wherein the Ca / P molar ratio is n(Ca 2+ ):n(PO 4 3- )=1.67:1;

[0037] (3) At room temperature, quickly transfer the homogeneous mixture in step (2) to a hexagonal mold. After ultrasonically eliminating air bubbles, place it in a refrigerator at -20°C for 24 hours, and then transfer it to a freeze dryer. , freeze-dried at -109°C for 3 days;

[0038] (4) Submerge the freeze-dried molded sample in step (3) in an alkaline solution (1:1, v / v) with pH = 9, place it in a constant temperature oscillator at 37°C for 8 hours, and wash it with water until After neutralization, refreeze and then dry to...

Embodiment 2

[0044] (1) dissolving 1.00g of chitosan in an acetic acid solution with a volume fraction of 2%, and magnetic stirring for 30min under a water bath condition of 37° C., to obtain a chitosan acid solution;

[0045] (2) Each 6mL of 2mol / L soluble calcium salt solution and 1.2mol / L soluble phosphate solution is added in the mixed solution of step (1) successively, and the time interval is 30min; wherein the Ca / P molar ratio is n(Ca 2+ ):n(PO 4 3- )=1.67:1;

[0046] (3) At room temperature, quickly transfer the homogeneous mixture in step (2) to a hexagonal mold. After ultrasonically eliminating air bubbles, place it in a refrigerator at -20°C for 24 hours, and then transfer it to a freeze dryer. , freeze-dried at -109°C for 3 days;

[0047] (4) Submerge the freeze-dried molded sample in step (3) in an alkaline solution (1:1, v / v) with pH = 10, place it in a constant temperature oscillator at 37°C for 8 hours, and wash it with water until After neutralization, refreeze and the...

Embodiment 3

[0052] (1) dissolving 1.00g of chitosan in an acetic acid solution with a volume fraction of 2%, and magnetic stirring for 30min under a water bath condition of 37° C., to obtain a chitosan acid solution;

[0053] (2) Add 8 mL each of 2mol / L soluble calcium salt solution and 1.2mol / L soluble phosphate solution to the mixed solution of step (1) successively, with a time interval of 30min; wherein the Ca / P molar ratio is n(Ca 2+ ):n(PO 4 3- )=1.67:1;

[0054] (3) At room temperature, quickly transfer the homogeneous mixture in step (2) to a hexagonal mold. After ultrasonically eliminating air bubbles, place it in a refrigerator at -20°C for 24 hours, and then transfer it to a freeze dryer. , freeze-dried at -109°C for 3 days;

[0055] (4) Submerge the freeze-dried molded sample in step (3) in an alkaline solution (1:1, v / v) with pH = 10, place it in a constant temperature oscillator at 37°C for 12 hours, and wash it with water until After neutralization, refreeze and then dr...

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Abstract

The invention provides a bioactive ceramic armor with mechanical adaptability and a preparation method thereof. Chitosan, polycaprolactone and hydroxyapatite are used as rigid ceramic units, and polycaprolactone is used as a flexible joint connecting the ceramic units. Partly, through casting technology, in situ biomimetic construction of rigid and flexible bioactive ceramic armor materials. The biologically active armor material prepared by the invention not only has certain mechanical adaptability, but also has good biological activity. Facing the repair of skull injuries in young children, skull repair in complex dynamic mechanical environments such as intracranial hypertension, by implanting this kind of ceramic armor, it can adaptively match the mechanical stretching requirements, and at the same time induce the healthy growth of defective skull tissue to achieve normal repair tissue. form and function.

Description

technical field [0001] The invention belongs to the field of composite materials, and in particular relates to a bioactive ceramic armor with mechanical adaptability and a preparation method thereof. Background technique [0002] As the command center of the human body, the brain plays a vital role in the regulation of human normal physiological activities and behavioral functions, and the protection of this key part is mainly performed by the skull. Facing the treatment of skull defects, the traditional strategy is to directly implant bone tissue engineering scaffolds into the tissue defect site, and provide support space for cell chemotaxis, migration and proliferation through scaffold bridging technology, while self-degradation, new tissue fills and matures , thereby repairing the defect. [0003] However, clinicians have discovered that the skull of mammals is not formed by a complete bone block, but by the combination of many bone blocks of different sizes. These func...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/12A61L27/18A61L27/20A61L27/50A61L27/56A61L27/58
CPCA61L27/12A61L27/18A61L27/20A61L27/50A61L27/56A61L27/58A61L2430/02C08L5/08C08L67/04
Inventor 丁春梅赵耀孙凡李建树
Owner SICHUAN UNIV
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