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Novel process method for extracting hesperidin

A new process, the technology of hesperidin, is applied in the new process field of hesperidin extraction, which can solve the problems of large consumption of extraction solvent, slow progress of experimental reaction, no particularly strict control indicators, etc., and achieve the effect of reducing impurities and increasing content.

Pending Publication Date: 2020-07-03
严格生物科技产业发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Among them, the Soxhlet extraction method has the advantages of simple extraction process, but the experimental reaction progress is slow, multiple recrystallization extractions, and the extraction solvent consumes a lot
[0005] The microwave extraction method is less harmful to the environment, but the temperature change is not easy to control during the microwave extraction process, and the temperature rise will lead to partial hydrolysis of hesperidin, generating unnecessary impurities and reducing the purity of hesperidin
[0006] The traditional alkali extraction and acid precipitation method has the advantages of saving economy and simple process, but in the existing alkali extraction method, the control of crystallization pH is generally more random, there is no particularly strict control index, and the content of the final hesperidin product is largely Depends on the quality of the raw material

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Step A. pulverize the Fructus Fructus Fructus Fructus Fructus Raw Material, and pulverize particle size 50 orders;

[0031] Step B. Pretreat the pulverized raw materials with sodium citrate solution for 4 hours, and control the concentration of sodium citrate solution at 3%;

[0032] Step C. After processing and filtering, add the filter residue to the alkaline extract, control the concentration at 1.5%, and extract for 5 hours;

[0033] Step D. Pass the alkaline extract first through coarse filtration, then perform fine filtration, and transfer the filtrate to a stirring tank;

[0034] Step E. During the stirring process of the extraction filtrate, slowly add hydrochloric acid to adjust the pH, the pH is controlled at 5.5, and wait for crystallization for 8 hours;

[0035] Step F. Pass the crystallization solution through the plate frame, and rinse the filter cake with purified water until it is colorless, then blow dry the filter cake, and transfer it to a drying ove...

Embodiment 2

[0037] Step A. Pulverize the Fructus Fructus Citrus Fructus raw material, and pulverize particle size 40 orders;

[0038] Step B. Pretreating the pulverized raw materials with sodium citrate solution for 5 hours, and controlling the concentration of the sodium citrate solution at 1%;

[0039] Step C. After processing and filtering, add the filter residue to the alkaline extract, control the concentration at 0.5%, and extract for 6 hours;

[0040] Step D. Pass the alkaline extract first through coarse filtration, then perform fine filtration, and transfer the filtrate to a stirring tank;

[0041] Step E. During stirring the extraction filtrate, slowly add hydrochloric acid to adjust the pH, the pH is controlled at 6.5, and wait for crystallization for 6 hours;

[0042] Step F. Pass the crystallization solution through the plate frame, and rinse the filter cake with purified water until it is colorless, blow dry the filter cake, and transfer it to a drying oven for drying at a ...

Embodiment 3

[0044] Step A. Pulverize the Fructus Fructus Citrus Fructus raw material, the pulverizing particle size is 60 orders;

[0045] Step B. Pretreat the pulverized raw materials with sodium citrate solution for 3 hours, and control the concentration of sodium citrate solution at 5%;

[0046] Step C. After processing and filtering, add the filter residue to the alkaline extract, control the concentration at 2.5%, and extract for 3 hours;

[0047] Step D. Pass the alkaline extract first through coarse filtration, then perform fine filtration, and transfer the filtrate to a stirring tank;

[0048] Step E. During the stirring process of the extraction filtrate, slowly add hydrochloric acid to adjust the pH, control the pH at 4.5, and wait for crystallization for 12 hours;

[0049] Step F. Pass the crystallization solution through the plate frame, and rinse the filter cake with purified water until it is colorless, then blow dry the filter cake, and transfer it to a drying oven for dry...

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Abstract

The invention provides a novel process method for extracting hesperidin. The novel process method comprises the following steps: crushing dried immature bitter oranges, carrying out pretreating with asodium citrate solution, carrying out extracting with an alkali liquor, adding acid for crystallization, and carrying out filtering and drying. The core of the application is the pretreatment processwith the sodium citrate solution; in the pretreatment process, a raw material can be washed; meanwhile, isomers of the hesperidin in part of raw material components can be removed. The concentrationof the sodium citrate solution is strictly controlled, so impurities in a hesperidin product can be effectively reduced, and the content of the hesperidin is increased. During crystallization, the pHvalue of an extracting solution is adjusted to be 4.5-6.5 by using the acid.

Description

technical field [0001] The invention relates to the technical field of plant extraction, in particular to a new process for extracting hesperidin. Background technique [0002] Chinese aliases of hesperidin: hesperidin, nobiletin, nobiletin, dihydroflavone glycoside. Hesperidin is the main active ingredient of tangerine peel, molecular formula C28H34O15. Studies have shown that hesperidin has physiological functions such as anti-oxidation, anti-allergy, antibacterial and anti-inflammatory, anti-virus and anti-cancer, prevention of cardiovascular diseases, lowering blood pressure, lowering low-density cholesterol, etc., and has high medicinal value. In addition, it is used as a natural oxidizing agent in the food and cosmetic industries. [0003] At present, the sources of extracting hesperidin mainly include young orange fruits and young orange fruits. The extraction techniques mainly include Soxhlet extraction, alkali extraction and acid precipitation, microwave extracti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H17/07C07H1/08
CPCC07H17/07C07H1/08
Inventor 夏强朱军刚栗思平甘圆渠樊绍明
Owner 严格生物科技产业发展有限公司
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