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Pharmaceutical composition for removing phlegm and relieving asthma and application of pharmaceutical composition

A composition and drug technology, applied in the field of drug spectrum, can solve the problems of low bioavailability, long dissolution time, affecting drug efficacy, etc.

Inactive Publication Date: 2020-07-07
FOSHAN SOIN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the characteristics of their preparation technology, tablets and capsules usually have long dissolution time, low dissolution rate, poor absorption and low bioavailability, which affect the full play of drug efficacy

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063] This embodiment provides a pharmaceutical composition for eliminating phlegm and relieving asthma: the content of theophylline in its unit preparation is 120 mg, the content of guaifenesin is 100 mg, and its dosage form is syrup.

[0064] Its preparation method is: dissolving theophylline and guaifenesin in appropriate amount of water, heating to 60°C, stirring and dissolving; adding 500mL of sucrose, adding appropriate amount of sodium benzoate and flavoring agent, stirring evenly, and filtering to obtain the product.

Embodiment 2

[0066] This embodiment provides a pharmaceutical composition for eliminating phlegm and relieving asthma, its dosage form is a soft capsule, which includes a drug suspension and rubber;

[0067] Among them, the prescription of drug suspension is:

[0068] Guaifenesin 0.09kg, anhydrous theophylline 0.15kg, water 0.012kg, PEG400 6.38kg;

[0069] The rubber material can be selected according to the prior art.

[0070] Its preparation method is:

[0071] Weigh about 5.75kg of polyethylene glycol 400 and place it in the batching pot, add 0.012kg of purified water, mix well, stir to dissolve completely, heat to 35°C, and keep warm. Weigh 0.09kg of guaifenesin in the prescribed amount, pass through a 40-mesh sieve, add to the above solution under stirring, and fully dissolve to obtain the first solution, and continue to keep warm at 35°C. Weigh 0.15 kg of anhydrous theophylline, pass through a 40-mesh sieve, add to the first solution under stirring, mix well, add 400 to 6.38 kg of...

Embodiment 3

[0074] This embodiment provides a pharmaceutical composition for eliminating phlegm and relieving asthma, its dosage form is a soft capsule, which includes a drug suspension and rubber;

[0075] Among them, the prescription of drug suspension is:

[0076] Guaifenesin 0.09kg, anhydrous theophylline 0.15kg, water 0.036kg, PEG400 6.38kg;

[0077] The rubber material can be selected according to the prior art.

[0078] Its preparation method is:

[0079] Weigh about 6 kg of polyethylene glycol 400 and place it in the batching pot, add 0.036 kg of purified water, mix well, stir to dissolve completely, heat to 35°C, and keep warm. Weigh 0.09 kg of guaifenesin in the prescribed amount, pass through a 40-mesh sieve, add to the above solution under stirring, and fully dissolve to obtain the first solution, and continue to keep warm at 35°C. Weigh 0.15 kg of anhydrous theophylline, pass through a 40-mesh sieve, add to the first solution under stirring, mix well, add 400 to 6.38 kg of...

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PUM

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Abstract

The present invention discloses a pharmaceutical composition for removing phlegm and relieving asthma. The pharmaceutical composition contains theophylline, guaifenesin and auxiliary materials; and the content of the theophylline is 120-200 mg per unit preparation and the content of the guaifenesin is 80-120 mg per unit preparation. Correspondingly, the present invention also discloses an application of the above-mentioned pharmaceutical composition for removing phlegm and relieving asthma in medicines for treating abundant phlegm and cough symptoms in respiratory system diseases. The theophylline and guaifenesin are combined to effectively improve therapeutic effects of removing phlegm and relieving asthma, so that the medicine can be used for treatment of asthmatic bronchitis, chronic bronchitis, bronchial asthma and other diseases.

Description

technical field [0001] The invention relates to the technical field of drug spectrum, in particular to a pharmaceutical composition for eliminating phlegm and relieving asthma and its application. Background technique [0002] According to statistics, respiratory diseases account for about 1 / 4 of internal medicine patients. In my country's population statistics, respiratory diseases are the second cause of death. The main symptoms of respiratory diseases are cough, expectoration and asthma. In recent years, there are gradually more and more drugs available clinically, and guaifenesin is one of them. [0003] Guaifenesin is a major expectorant that dissolves thick mucus and relieves dyspnea. Expectorants reduce the viscosity of bronchial secretions, thereby increasing the flow of mucus, which can then be removed by coughing. At the same time, expectorants can also thin the mucus barrier, and as a result, cough-increasing agents (such as citric acid, dust, allergens, etc.) c...

Claims

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Application Information

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IPC IPC(8): A61K31/522A61K31/09A61K9/48A61K47/10A61K47/04A61P11/06A61P11/10A61P11/00A61P11/14
CPCA61K31/522A61K31/09A61K9/4866A61K9/4816A61K9/485A61P11/06A61P11/10A61P11/00A61P11/14A61K2300/00
Inventor 黄锦峰孟召光窦荣霞付虎生杨嘉宗
Owner FOSHAN SOIN PHARMA CO LTD
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