Polyurethane/nano-diamond bone repair composite material and preparation method thereof
A nano-diamond and composite material technology, which is applied in the field of biomedical composite materials, polyurethane/nano-diamond bone repair composite materials and their preparation, can solve problems in the field of unfavorable bone repair, the inability of composite materials to resist bacterial infection, etc., and achieve improved mechanical properties. , The preparation method is simple to operate, and the hydrophilicity is improved.
Active Publication Date: 2022-06-21
NANJING UNIV OF SCI & TECH
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Problems solved by technology
However, the composite material prepared by it cannot resist bacterial infection, which is not conducive to the practical application in the field of bone repair
Method used
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Embodiment 1
[0028] Example 1: Preparation process of composite material
[0029] Disperse 400 mg of nanodiamond (ND) in a water-ethanol (1:9) mixture, add 1000 uL of 3-bromopropyltrimethoxysilane, and react at 50 °C for 24 h. Then add 400mg copolymer of 4-vinylpyridine and hydroxyethyl methacrylate, and add 0.2g bromoethyl methacrylate to introduce double bond, finally add 2mL bromohexane quaternization reaction for 48 hours, centrifuge, The product was dried under vacuum at 25°C to obtain quaternary ammonium salt modified nanodiamond (QND).
[0030] Then, 4 g of polyε-caprolactone diol (PCL-diol) was placed in a 50 mL three-necked flask and dehydrated at 60° C. for 24 h in a vacuum drying oven. Then use an oil bath to heat at 60°C, under nitrogen protection, add 0.65 mL of hexamethylene diisocyanate (HDI) dropwise under mechanical stirring, heat up to 85°C and react for 2 hours, at which time a prepolymer (IPU) is obtained. Then, the reaction temperature was lowered to 40° C., 0.5 mL o...
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Abstract
The invention discloses a polyurethane / modified nano-diamond antibacterial composite material and a preparation method thereof. The composite material is a polyurethane with excellent properties synthesized by a pre-polymerization method, and then mixed with nano-diamonds with quaternary ammonium salt groups on the surface by a copolymerization method to prepare a composite material that can be applied in the field of bone repair. The composite material prepared by the present invention maintains the excellent properties of polyurethane, such as thermal stability and good biocompatibility, and at the same time endows the material with excellent antibacterial properties, in addition improves the mechanical properties and hydrophilicity of polyurethane, and adds nano-diamond When the content is 1%, the performance of the composite material is optimal.
Description
technical field [0001] The invention belongs to the field of antibacterial composite materials and relates to a biomedical composite material, in particular to a polyurethane / nanodiamond bone repair composite material and a preparation method thereof. Background technique [0002] For large bone defects caused by trauma, infection, tumor, and dysplasia, which cannot heal naturally by relying solely on the repair of bone tissue itself, bone transplantation is required. Polyurethane (PU), prepared from polyols, isocyanates and chain extenders. It has high flexibility, high wear, good strength, good chemical resistance and sufficient biocompatibility, but the shortcomings such as insufficient mechanical properties and lack of antibacterial properties limit its application. [0003] For example, it has been reported previously that aliphatic polyurethane (PU) scaffolds were synthesized by foaming methods using non-toxic components. Furthermore, hydroxyapatite (HA) particles we...
Claims
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IPC IPC(8): A61L27/50A61L27/08A61L27/16A61L27/54C08F283/00C08F220/20C08F222/14
CPCA61L27/50A61L27/08A61L27/16A61L27/54C08F283/008A61L2430/02A61L2300/404A61L2300/108A61L2400/12C08L51/08C08F220/20
Inventor 邢晓东王莉娜曹巍巍汪熙李培礼张高珂
Owner NANJING UNIV OF SCI & TECH