Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

New application of dendrobium to preparation of product for preventing and treating angiosteosis

A vascular calcification and new-purpose technology, which is applied in the direction of cardiovascular system diseases, the function of food ingredients, and medical preparations containing active ingredients, etc., can solve the problems of poor effect, achieve the reduction of vascular calcification area, high safety, and inhibit the occurrence The effect of development

Pending Publication Date: 2020-07-10
安徽同济生生物科技有限公司 +1
View PDF2 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, traditional drugs are less effective in effectively preventing or reversing vascular calcification. Dendrobium is a plant of the genus Dendrobium in the family Orchidaceae. , usually used as a nourishing herb and health food, the Chinese Pharmacopoeia records its functions and indications as: benefiting the stomach and promoting body fluid, nourishing yin and clearing away heat; used for fluid injury in febrile diseases, dry mouth, polydipsia, insufficient stomach yin, lack of food, retching, and deficiency after illness Fever persists, yin deficiency and hyperactivity of fire, bone steaming, fatigue and heat, blurred eyesight, muscle and bone flaccidity and softness, Dendrobium is not used in the prevention and treatment of vascular calcification

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • New application of dendrobium to preparation of product for preventing and treating angiosteosis
  • New application of dendrobium to preparation of product for preventing and treating angiosteosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Example 1 Dendrobium Huoshanense inhibits vascular calcification in LDLR knockout mice

[0026] 1. Preparation of LDLR- / - mouse model of vascular calcification

[0027] Seventeen male LDLR- / - mice about 6 weeks old, weighing about 22 g, were fed adaptively for 1 week, and were randomly divided into 2 groups. Control group (Ctrl group): 8 mice, fed with high-fat food; Huoshanense Dendrobium treatment group (DH group): 9 mice, according to the recommendation of "Chinese Pharmacopoeia" (Part 1), the dosage of fresh products of Huoshanense Dendrobium was enlarged 10 times, that is to feed the fresh product of Dendrobium Huoshanense at 5g / kg·mouse body weight per day after being crushed and mixed with high-fat food. All mice were given free access to food and water. After 18 weeks of feeding, the mice were euthanized, and relevant tissues and organs such as the aorta were collected for related research.

[0028] 2. Alizarin Red S Staining of Aortic Root

[0029] After the...

Embodiment 2

[0032] Example 2 Dendrobium candidum inhibits vascular calcification in LDLR knockout mice

[0033] 1. Preparation of LDLR- / - mouse model of vascular calcification

[0034] Twenty male LDLR- / - mice aged about 6 weeks, weighing about 22 g, were fed adaptively for 1 week, and were randomly divided into 2 groups. Control group (Ctrl group): 10 mice, fed with high-fat food; Dendrobium candidum treatment group (DO group): 10 mice, according to the recommendation of "Chinese Pharmacopoeia" (Part 1), the dosage of fresh Dendrobium candidum was enlarged 10 times, that is to feed the fresh product of Dendrobium Huoshanense at 5g / kg·mouse body weight per day after being crushed and mixed with high-fat food. All mice were given free access to food and water. After 18 weeks of feeding, the mice were euthanized, and relevant tissues and organs such as the aorta were collected for related research.

[0035] 2. Alizarin red S staining of aortic root, same as embodiment 1

[0036] 3. Exper...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Thicknessaaaaaaaaaa
Login to View More

Abstract

The invention relates to the technical field of medicines and special medical foods, in particular to a new application of dendrobium to the preparation of a product for preventing and treating angiosteosis. The dendrobium is applied according to a dosage ratio in the preparation of the product for preventing and treating the angiosteosis; an experiment proves that the angiosteosis area can be remarkably reduced and the occurrence and development of the angiosteosis are inhibited; the angiosteosis inhibiting effect of the dendrobium is remarkable; the effect is remarkable and the safety is extremely high, so that the dendrobium has the wide application prospect in angiosteosis prevention and treatment; large-scale artificial planting has been realized; the dendrobium can be one or more ofdendrobium huoshanense, dendrobium officinale, dendrobium chrysanthum, dendrobium fimbriatum, dendrobium chrysotoxum and medicinal dendrobium with the same properties; and the dendrobium is rich in source and relatively low in price, so that the medicine use burden of patients can be reduced.

Description

technical field [0001] The invention relates to a new application of dendrobium, specifically the new application of dendrobium in the preparation of products for prevention, treatment and prevention and treatment of vascular calcification diseases, and belongs to the technical field of medicine and food for special medical treatment. Background technique [0002] Vascular calcification is common in people with aging, atherosclerosis, hypertension, diabetes, dyslipidemia, heart valve disease, chronic kidney disease, etc. It is produced by ectopic deposition of hydroxyapatite on the blood vessel wall; vascular calcification increases the risk of heart failure. The risk of cardiovascular disease, stroke, and atherosclerotic plaque rupture is an important risk factor for increasing the morbidity and mortality of cardiovascular diseases; therefore, vascular calcification is receiving more and more attention worldwide. Initially, researchers believed that vascular calcification i...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K36/8984A61P9/14A23L33/00
CPCA23V2002/00A61K36/8984A23L33/00A61P9/14A23V2200/30
Inventor 余茂耘韩际宏段亚君梁英权杨潇潇陈元利
Owner 安徽同济生生物科技有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com