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A kind of bone cement composite material and preparation method thereof

A composite material and bone cement technology, which is applied in the field of medical materials, can solve the problems of poor bonding and poor stability of acrylic resin bone cement, and achieve the effects of promoting wound healing, high stability, and improving biological safety

Active Publication Date: 2021-09-07
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide a bone cement composite material and its preparation method to solve the problems of poor stability of existing phase change materials and poor bonding with acrylic resin bone cement

Method used

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  • A kind of bone cement composite material and preparation method thereof
  • A kind of bone cement composite material and preparation method thereof
  • A kind of bone cement composite material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] The bone cement composite material of this embodiment includes: a solid phase component and a liquid phase component, and the mass ratio of the solid phase component and the liquid phase component is 2:1;

[0043] Wherein, the solid phase components include: methyl methacrylate copolymer, paraffin wax / polymethyl methacrylate-methylenebisacrylamide phase change microcapsules, in the solid phase components, methyl methacrylate copolymer The mass fraction of paraffin wax / polymethyl methacrylate-methylenebisacrylamide phase change microcapsules is 30%; the liquid phase component includes methyl methacrylate.

[0044] Wherein, the preparation method of paraffin / polymethyl methacrylate-methylenebisacrylamide variable microcapsules comprises the following steps:

[0045] (1) After mixing methyl methacrylate, paraffin and cross-linking agent with water, heat in a water bath at 40°C, stir at 3000rpm for 10 minutes, add emulsifier and continue to stir and shear emulsify at 3000rp...

Embodiment 2

[0053] The bone cement composite material of this embodiment includes: a solid phase component and a liquid phase component, and the mass ratio of the solid phase component and the liquid phase component is 2:1;

[0054] Wherein, the solid phase components include: methyl methacrylate copolymer, paraffin wax / polymethyl methacrylate-methylenebisacrylamide phase change microcapsules, in the solid phase components, methyl methacrylate copolymer The mass fraction of paraffin wax / polymethyl methacrylate-methylenebisacrylamide phase change microcapsules is 20%;

[0055] The liquid phase component includes methyl methacrylate.

[0056] Wherein, the preparation method of paraffin / polymethyl methacrylate-methylenebisacrylamide phase-change microcapsules comprises the following steps:

[0057] (1) After mixing methyl methacrylate, paraffin and crosslinking agent with water, heat in a water bath at 50°C, stir at 5000rpm for 15min, add emulsifier and continue to stir and shear emulsify a...

Embodiment 3

[0065] The bone cement composite material of this embodiment includes: a solid phase component and a liquid phase component, and the mass ratio of the solid phase component and the liquid phase component is 2:1;

[0066] Wherein, the solid phase components include: methyl methacrylate copolymer, paraffin wax / polymethyl methacrylate-methylenebisacrylamide phase change microcapsules, in the solid phase components, methyl methacrylate copolymer The mass fraction of paraffin wax / polymethyl methacrylate-methylenebisacrylamide phase change microcapsules is 10%;

[0067] The liquid phase component includes methyl methacrylate.

[0068] Wherein, the preparation method of paraffin / polymethyl methacrylate-methylenebisacrylamide phase-change microcapsules comprises the following steps:

[0069] (1) After mixing methyl methacrylate, paraffin and cross-linking agent with water, heat in a water bath at 60°C, stir at 8000rpm for 20min, add emulsifier and continue to stir and shear emulsify ...

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Abstract

The invention discloses a bone cement composite material and a preparation method thereof, and relates to the technical field of medical materials. It includes: solid phase components and liquid phase components, the mass ratio of the solid phase components and liquid phase components is 2:1; wherein, the solid phase components include: methyl methacrylate copolymer, paraffin / Polymethyl methacrylate-methylenebisacrylamide phase change microcapsules, in the solid phase component, the mass fraction of methyl methacrylate copolymer is 70-90%, paraffin wax / polymethyl methacrylate The mass fraction of the ester-methylenebisacrylamide phase-change microcapsules is 10-30%; the liquid phase component includes methyl methacrylate. The raw material of the bone cement composite material of the present invention has high biological safety, the paraffin wax / polymethyl methacrylate-methylenebisacrylamide phase change microcapsules have high stability themselves, and have good combination with acrylic resin bone cement, which can effectively reduce the Tissue heat damage increases the safety of acrylic polymer bone cement used in humans.

Description

technical field [0001] The invention relates to the technical field of medical materials, in particular to a bone cement composite material and a preparation method thereof. Background technique [0002] Acrylic resin bone cement has been used in orthopedics for more than 50 years, including total joint replacement, vertebroplasty, bone defect reconstruction, and treatment of infectious lesions. However, in clinical applications, the side effects of methyl methacrylate monomer such as toxicity, strong exothermicity, non-degradation in the body, and excessive mechanical strength are gradually appearing. These conditions can lead to cardiac arrest, decreased blood pressure, nerve root or spinal cord collateral damage, permanent foreign body retention, and even death from cement implantation syndrome. Among them, the strong exotherm generated by the polymerization of acrylic resin bone cement monomer can lead to a local transient temperature rise, stimulate the body to produce...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/48A61L27/50A61L27/56A61L27/58C08F220/14C08F222/38
CPCA61L27/48A61L27/50A61L27/56A61L27/58A61L2430/02C08F220/14C08F222/385C08L33/12C08L33/26C08L5/08C08L89/06
Inventor 李吉东夏雪石锐李玉宝左奕
Owner SICHUAN UNIV
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