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Sulfadoxine preparation process

A preparation process, the technology of sulfadoxine, which is applied in the field of medical production, can solve the problems of weakened sulfadoxine yield, cumbersome steps, and poor practicability, and achieve the effect of low equipment requirements, simple equipment, and convenient operation

Pending Publication Date: 2020-07-14
CHANGSHU JINSHEN MEDICAL PROD CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The object of the present invention is to provide a kind of sulfadoxine preparation process, to solve the existing sulfadoxine preparation process steps proposed in the above-mentioned background technology is loaded down with trivial details, error-prone, easy to operate, cost height, sulfadoxine yield weakens greatly, The problem of poor usability

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] A preparation process of sulfadoxine, the specific preparation process steps are as follows:

[0024] Step 1: The technicians are familiar with the special plan for the preparation process of sulfadoxine in detail, raise doubts and solve them, and finally reach an agreement on the special plan and submit it to the technical director for approval;

[0025] Step 2: First add the methanol solution into the reaction kettle with a stirrer, then put in sodium hydroxide, start stirring and put in 4-(p-aminobenzenesulfonamido)-5-methoxy-6-chloropyrimidine for reflux Reaction, control reflux reaction temperature and control reflux reaction time, after the reaction finishes, reclaim methanol to dryness, obtain sodium methylate;

[0026] Step 3: Put 184g of 27%-28% sodium methoxide into the reaction flask, evaporate the methanol to dryness, then put 83g of methyl methoxyacetate and 142g of diethyl oxalate into the reaction bottle, and the temperature will rise naturally;

[0027]...

Embodiment 2

[0037] A preparation process of sulfadoxine, the specific preparation process steps are as follows:

[0038] Step 1: The technicians are familiar with the special plan for the preparation process of sulfadoxine in detail, raise doubts and solve them, and finally reach an agreement on the special plan and submit it to the technical director for approval;

[0039] Step 2: First add the methanol solution into the reaction kettle with a stirrer, then put in sodium hydroxide, start stirring and put in 4-(p-aminobenzenesulfonamido)-5-methoxy-6-chloropyrimidine for reflux Reaction, control reflux reaction temperature and control reflux reaction time, after the reaction finishes, reclaim methanol to dryness, obtain sodium methylate;

[0040] Step 3: Put 184g of 27%-28% sodium methoxide into the reaction flask, evaporate the methanol to dryness, then put 83g of methyl methoxyacetate and 142g of diethyl oxalate into the reaction bottle, and the temperature will rise naturally;

[0041]...

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Abstract

The invention discloses a sulfadoxine preparation process which comprises the following specific preparation process steps: 1, technicists are familiar with a special scheme of the sulfadoxine preparation process in detail, put forward doubts and solve the doubts, and finally submit a consistent special scheme to a technical director for approval; 2, the methanol solution is added into a reactionkettle with a stirrer, sodium hydroxide is added, stirring is started, 4-(p-aminobenzenesulfonamido)-5-methoxy-6-chloropyrimidine is added, a reflux reaction is carried out, the reflux reaction temperature and the reflux reaction time are controlled, and methanol is recovered to dryness after the reaction ends in order to obtain sodium methoxide; 3, 184 g of 27%-28% sodium methoxide is put into the reaction bottle, methyl alcohol is evaporated to dryness, then a mixed solution of 83 g of methyl methoxyacetate and 142 g of diethyl oxalate is put into the reaction bottle, and the temperature rises naturally. The sulfadoxine preparation process is stable, reliable, simple in equipment, low in manufacturing cost, convenient to operate, high in practicability and suitable for wide application and popularization.

Description

technical field [0001] The invention belongs to the technical field of medical production, and in particular relates to a preparation process of sulfadoxine. Background technique [0002] Sulfadoxine has antibacterial effects on staphylococcus, pneumococcus, meningococcus, Escherichia coli, Proteus, Shigella, bacillus, Alcaligenes, Salmonella, etc., and the minimum inhibitory concentration is 16-32 μg / ml. The antibacterial effect on common bacteria is weaker than that of other sulfa drugs. For Escherichia coli, paraescherichia coli, Staphylococcus aureus and Shigella, when the drug concentration is 12.5 μg / ml, 50% of the strains are inhibited. It is reported abroad that SDM' is also effective for malaria, leprosy and tuberculosis. The existing sulfadoxine preparation process steps are cumbersome, error-prone, easy to operate, high in cost, greatly weakened in sulfadoxine yield, and poor in practicability. Contents of the invention [0003] The object of the present inv...

Claims

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Application Information

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IPC IPC(8): C07D239/69
CPCC07D239/69
Inventor 李涛
Owner CHANGSHU JINSHEN MEDICAL PROD CO LTD
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