Sulfadoxine preparation process
A preparation process, the technology of sulfadoxine, which is applied in the field of medical production, can solve the problems of weakened sulfadoxine yield, cumbersome steps, and poor practicability, and achieve the effect of low equipment requirements, simple equipment, and convenient operation
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Embodiment 1
[0023] A preparation process of sulfadoxine, the specific preparation process steps are as follows:
[0024] Step 1: The technicians are familiar with the special plan for the preparation process of sulfadoxine in detail, raise doubts and solve them, and finally reach an agreement on the special plan and submit it to the technical director for approval;
[0025] Step 2: First add the methanol solution into the reaction kettle with a stirrer, then put in sodium hydroxide, start stirring and put in 4-(p-aminobenzenesulfonamido)-5-methoxy-6-chloropyrimidine for reflux Reaction, control reflux reaction temperature and control reflux reaction time, after the reaction finishes, reclaim methanol to dryness, obtain sodium methylate;
[0026] Step 3: Put 184g of 27%-28% sodium methoxide into the reaction flask, evaporate the methanol to dryness, then put 83g of methyl methoxyacetate and 142g of diethyl oxalate into the reaction bottle, and the temperature will rise naturally;
[0027]...
Embodiment 2
[0037] A preparation process of sulfadoxine, the specific preparation process steps are as follows:
[0038] Step 1: The technicians are familiar with the special plan for the preparation process of sulfadoxine in detail, raise doubts and solve them, and finally reach an agreement on the special plan and submit it to the technical director for approval;
[0039] Step 2: First add the methanol solution into the reaction kettle with a stirrer, then put in sodium hydroxide, start stirring and put in 4-(p-aminobenzenesulfonamido)-5-methoxy-6-chloropyrimidine for reflux Reaction, control reflux reaction temperature and control reflux reaction time, after the reaction finishes, reclaim methanol to dryness, obtain sodium methylate;
[0040] Step 3: Put 184g of 27%-28% sodium methoxide into the reaction flask, evaporate the methanol to dryness, then put 83g of methyl methoxyacetate and 142g of diethyl oxalate into the reaction bottle, and the temperature will rise naturally;
[0041]...
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