Application of selfheal extract in medicine preparation

A technology of Prunella vulgaris and its extract, which is applied in the field of preparation of drugs for the treatment of thyroid cancer and drugs for preventing postoperative recurrence of thyroid cancer, which can solve the problems of thyroid cancer and achieve the effect of preventing recurrence and preventing postoperative recurrence

Pending Publication Date: 2020-07-17
GUIYANG XINTIAN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no specific drug and postoperative adjuvant therapy for thyroid cancer

Method used

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  • Application of selfheal extract in medicine preparation
  • Application of selfheal extract in medicine preparation
  • Application of selfheal extract in medicine preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Embodiment 1 prepares Prunella vulgaris extract

[0022] Add 700mL of 80vol% ethanol aqueous solution to 100g of Prunella vulgaris fruit ears, carry out ultrasonic extraction for 2 hours, repeat the above-mentioned ultrasonic extraction three times, and combine the extracts to obtain the crude extract of Prunella vulgaris. Then the crude extract of Prunella vulgaris is passed through a macroporous resin column, followed by gradient elution with water, 10-30 vol% ethanol aqueous solution and 50-95 vol% ethanol aqueous solution, and the elution after 50-95 vol% ethanol aqueous solution is collected. Deliquoring and concentrating at 60-70°C to a relative density of 1.05-1.15 to obtain the extract of Prunella vulgaris Extract I.

[0023] Let the extract of Prunella vulgaris extract Ⅰ stand for 24 hours, filter, add auxiliary materials to the filtrate, heat and boil to dissolve, add water to the prescribed amount, mix well, cool to 2-10°C and refrigerate for 24 hours, pass...

Embodiment 2

[0024] Embodiment 2 animal test

[0025] Male Balb / c nude mice were inoculated with thyroid papillary carcinoma, and after tumor formation in the mice (i.e., the tumor volume exceeded 100mm 3 ), were grouped and marked according to the tumor size, so that the average value of the tumor volume of each group of mice was approximately the same, and were randomly divided into model group, Prunella vulgaris low-dose group (125mg / mL), Prunella vulgaris medium-dose group (250mg / mL) mL) and the Prunella vulgaris high-dose group (500mg / mL), each gavage amount was 0.4mL, once a day, for 2 consecutive weeks. During the administration period, the length, width and diameter of the mouse tumor were measured every day, and the volume change of the mouse tumor was monitored. The results were as follows: figure 1 and figure 2 shown.

[0026] It can be seen from the figure that the tumor volume of the mice administered at each time point was significantly smaller than that of the model gr...

Embodiment 3

[0030] Embodiment 3: clinical trial

[0031] Patients with thyroid cancer surgery were selected and randomly divided into a control group (41 people) and an observation group (56 people). The control group did not take medicine after surgery, and the observation group took Prunella vulgaris extract oral liquid after surgery, 10mL / bottle / time, twice / day, taking continuously for 3 months. The symptoms and signs, thyroid function (FT3, FT4, TSH), serum thyroid binding globulin (TG), antithyroglobulin antibody (TGAb) and thyroid Microsomal antibody (TMA), the results are shown in Tables 2 and 3.

[0032] It can be found that the FT3 level of the patients in the control group increased significantly one month after the operation, while only one person in the observation group increased after taking the Prunella vulgaris extract oral liquid, and there was a statistical difference between the two groups (χ 2 =92.99, P<0.01); 1 month and 3 months after operation, the number of a...

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Abstract

The invention discloses an application of a selfheal extract in medicine preparation, and belongs to the field of traditional Chinese medicines. The selfheal extract is prepared by subjecting selfhealfruit-spike to ultrasonic extraction, macroporous resin column gradient elution and heating concentration. When used for preparing medicines for treating thyroid cancer and preventing recurrence of thyroid cancer after operation, the selfheal extract is used as an active ingredient, the weight percentage content of the total organic acid components is not less than 20%, and the weight percentagecontent of the total flavonoid components is not less than 10%. Animal experiments prove that: the selfheal extract can effectively inhibit the increase of the volume of the thyroid papillary carcinoma, has concentration dependence, and can be used for treating thyroid cancer; and clinical tests prove that the selfheal extract has the effects of stabilizing the thyroid function and other abnormalindexes after the operation of a thyroid cancer patient, can be used for preventing the recurrence of the thyroid cancer, and provides a new medicine way for treating thyroid diseases and preventing the recurrence after the operation.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, and relates to the application of Prunella vulgaris extract in the preparation of medicines, in particular to the preparation of medicines for treating thyroid cancer and preventing postoperative recurrence of thyroid cancer. Background technique [0002] Thyroid cancer is a malignant tumor originating from thyroid follicular epithelium or parafollicular epithelial cells, and it is also the most common malignant tumor of the head and neck. In recent years, the incidence of thyroid cancer has increased rapidly worldwide. According to data from the National Cancer Registry Center, the incidence of thyroid cancer in urban areas in my country ranks fourth among all female malignant tumors; % rate continued to grow. For thyroid cancer, there are mainly radiotherapy, chemotherapy, and surgery. Chinese patent medicine is often used as a combined treatment of thyroid cancer surgery, chemothera...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/536A61P35/00
CPCA61K36/536A61K2236/333A61K2236/39A61K2236/55A61P35/00
Inventor 李定祥郭碧泽张杰陆家强李慧民邱子梁
Owner GUIYANG XINTIAN PHARMA CO LTD
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