Preparation method and application of chiral Co-MOF/CoSR/PU core-shell composite material

A composite material, chirality technology, applied in the direction of material analysis, material analysis, material electrochemical variables, etc. by electromagnetic means, to achieve the effects of easy industrialization, improved conductivity, and simple process

Inactive Publication Date: 2020-07-24
UNIV OF JINAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the research on electrochem...

Method used

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  • Preparation method and application of chiral Co-MOF/CoSR/PU core-shell composite material
  • Preparation method and application of chiral Co-MOF/CoSR/PU core-shell composite material
  • Preparation method and application of chiral Co-MOF/CoSR/PU core-shell composite material

Examples

Experimental program
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Embodiment 1

[0031] Example 1 A preparation method of a chiral Co-MOF / CoSR / PU core-shell composite material Dissolve 1.8mmol cobalt nitrate hexahydrate and 7mmol 2-methylimidazole in 12mL ethanol respectively, mix the above two solutions, and statically Placed for 24 hours, centrifuged, washed with ethanol for 3 times, the Co-MOF was prepared; 5 mL of 0.2 M L-cysteine ​​aqueous solution was added to the prepared Co-MOF for blending, magnetically stirred for 1 hour, and the centrifugation was continued. After washing with ethanol for 3 times, drying at 85°C to constant weight, the chiral Co-MOF / CoSR composite material was prepared;

[0032] 0.4g of isophorone diisocyanate, 0.2g of chiral Co-MOF / CoSR composite material and 15mL of water / DMF mixed solvent with a volume ratio of 15 / 85 were blended, heated at 30°C for 1h, centrifuged, and the volume The ratio of 15 / 85 water / DMF was washed 3 times, and dried to constant weight at 90°C to obtain the chiral Co-MOF / CoSR / PU core-...

Embodiment 2

[0038] Example 2 Preparation method of a chiral Co-MOF / CoSR / PU core-shell composite material

[0039] Dissolve 2.0 mmol of cobalt nitrate hexahydrate and 8 mmol of 2-methylimidazole in 12 mL of ethanol respectively, mix the above two solutions, let stand at room temperature for 24 h, centrifuge and wash with ethanol three times to obtain Co-MOF; Add 6mL, 0.2M L-cysteine ​​aqueous solution to the Co-MOF for blending, magnetically stir for 1h, continue to centrifuge, wash with ethanol three times, and dry to constant weight at 85°C to prepare chiral Co-MOF / CoSR composite Material;

[0040] 0.5g of isophorone diisocyanate, 0.2g of chiral Co-MOF / CoSR composite material and 18mL of water / DMF mixed solvent with a volume ratio of 15 / 85 were blended, heated at 35°C for 1h, centrifuged, and the volume The ratio of 15 / 85 water / DMF was washed 3 times, and dried to constant weight at 90°C to obtain the chiral Co-MOF / CoSR / PU core-shell composite.

[0041] The structur...

Embodiment 3

[0042] Example 3 Preparation method of a chiral Co-MOF / CoSR / PU core-shell composite material

[0043] Dissolve 2.2 mmol of cobalt nitrate hexahydrate and 9 mmol of 2-methylimidazole in 15 mL of ethanol respectively, mix the above two solutions, let stand at room temperature for 24 h, centrifuge, and wash with ethanol for 3 times to obtain Co-MOF; Add 8mL, 0.2M L-cysteine ​​aqueous solution to the Co-MOF for blending, magnetically stir for 1h, continue to centrifuge, wash with ethanol three times, and dry to constant weight at 85°C to obtain a chiral Co-MOF / CoSR composite Material;

[0044] Blend 0.6g of isophorone diisocyanate, 0.3g of chiral Co-MOF / CoSR composite material and 20mL of water / DMF mixed solvent with a volume ratio of 15 / 85, heat at 40°C for 1h, centrifuge, and the volume The ratio of 15 / 85 water / DMF was washed 3 times, and dried to constant weight at 90°C to obtain the chiral Co-MOF / CoSR / PU core-shell composite.

[0045] The structure and pr...

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Abstract

The invention discloses a preparation method of a chiral Co-MOF/CoSR/PU core-shell composite material and application of the chiral Co-MOF/CoSR/PU core-shell composite material in efficient electrochemical recognition of penicillamine enantiomers, and belongs to the technical fields of nano-catalysis, chiral sensing and the like. The preparation method comprises the following main steps: synthesizing Co-MOF at room temperature, adding L-cysteine for chiral modification, and polymerizing with isophorone diisocyanate to obtain the chiral Co-MOF/CoSR/PU core-shell composite material. The composite material is low in raw material cost, simple in preparation process and low in reaction energy consumption. The prepared chiral sensor is used for sensitively detecting the content of L-penicillamine and D-penicillamine enantiomers, the method is simple and easy to operate, and the chiral detection effect is remarkable.

Description

technical field [0001] The invention relates to a preparation method and application of a chiral Co-MOF / CoSR / PU core-shell composite material, and belongs to the technical fields of nanomaterials, metal-organic complex polymers, catalysis, and the like. Background technique [0002] Isomers with the same molecular formula and structural formula, whose configurations are mirror images of each other but cannot overlap, are called enantiomers, or enantiomers for short, and the corresponding molecules are called chiral molecules. Many important molecules in the modern pharmaceutical and pesticide industries are chiral. In many cases, one of the enantiomers exhibits the desired physiological activity, while the other enantiomer exhibits inactivity or even toxicity. The identification and quantification of enantiomers is an important research topic since they exhibit the same physical and chemical properties in an achiral environment. At present, nuclear magnetic resonance (NMR)...

Claims

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Application Information

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IPC IPC(8): C08G18/75C08G18/64C08G18/38G01N27/30G01N27/48
CPCC08G18/3857C08G18/6415C08G18/755G01N27/308G01N27/48
Inventor 童磊王志玲王博
Owner UNIV OF JINAN
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