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Antibacterial drug as well as preparation and application thereof

A technology of antibacterial drugs and drugs, applied in the direction of antibacterial drugs, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve the problems of strengthening bacteria and difficulties in clinical anti-infection treatment, so as to reduce drug resistance and enhance bacterial resistance Drug resistance, the effect of reversing drug resistance

Active Publication Date: 2020-07-31
JIUJIANG UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

CRKP is not only resistant to most β-lactam antibacterial drugs, but also resistant to antibacterial drugs that are not related to the carbapenemase resistance mechanism, resulting in extensively drug-resistant Klebsiella pneumoniae The emergence and dissemination of (XDR-KP) has brought great difficulties to clinical anti-infection treatment, and has become a social and health issue of global concern
[0003] Due to the resistance of CRKP to most clinical antibiotics, more and more studies have shown that the combination of carbapenems and other antimicrobials in the treatment of CRKP infection compared with carbapenems alone, the traditional combination of antibacterial drugs It can improve the prognosis of patients to a certain extent, but it may bring greater side effects, and the combined application of antibacterial drugs may lead to the screening of more resistant bacteria and enhance bacterial resistance

Method used

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  • Antibacterial drug as well as preparation and application thereof
  • Antibacterial drug as well as preparation and application thereof
  • Antibacterial drug as well as preparation and application thereof

Examples

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preparation example Construction

[0025] The present invention provides the preparation method of antimicrobial drug described in above-mentioned technical scheme, comprising:

[0026] (1) mixing levofloxacin hydrochloride, palmatine hydrochloride and freeze-dried excipients to obtain a mixture, mixing the mixture with water for injection to obtain a mixture, filtering the mixture to obtain a medicinal solution;

[0027] (2) Make the medicinal solution into freeze-dried powder to obtain antibacterial drugs.

[0028] The invention mixes levofloxacin hydrochloride, palmatine hydrochloride and freeze-dried excipients to obtain a mixture, mixes the mixture with water for injection to obtain a mixture, and filters the mixture to obtain a medicinal solution. In the present invention, the volume ratio of the mass of the mixture to the water for injection is preferably 100-1000 g: 5000-100000 mL, more preferably 200-900 g: 5000-100000 mL. The filtering process preferably also includes mixing the mixture with activate...

Embodiment 1

[0042] An antibacterial drug, the mass ratio of levofloxacin hydrochloride and palmatine hydrochloride is 1:1.

[0043]Add 100g of levofloxacin hydrochloride, 100g of palmatine hydrochloride, 10g of mannitol, and 5g of sodium dihydrogen phosphate into 10,000ml of water for injection, stir well, add 10g of activated carbon, and filter the activated carbon after fully stirring. Add water for injection to make up to 10000ml, measure the pH value, add sodium dihydrogen phosphate to adjust the pH of the solution to be 5.0-7.0, the solution is filtered through two 0.2 μm filter membranes, and the filtrate is divided into 1000 bottles (10ml: 100 mg) in the vial, half stoppered, freeze-dried with a freeze-drying box to obtain the freeze-dried powder injection of levofloxacin hydrochloride and palmatine hydrochloride composition, vacuum stopper, out of the box, rolled aluminum cover, made 1000 antibacterial drugs .

Embodiment 2

[0045] An antibacterial drug, the mass ratio of levofloxacin hydrochloride and palmatine hydrochloride is 3:1.

[0046] Add 300g of levofloxacin hydrochloride, 100g of palmatine hydrochloride, 10g of mannitol, and 5g of sodium dihydrogen phosphate into 30,000ml of water for injection, stir evenly, add 30g of activated carbon, and filter the activated carbon after fully stirring. Add water for injection to make up to 30000ml, measure the pH value, add sodium dihydrogen phosphate to adjust the pH of the solution to be 5.0-7.0, the solution is filtered through two 0.2 μm filter membranes, and the filtrate is divided into 3000 bottles (10ml: 100 mg) in the vial, half stoppered, freeze-dried with a freeze-drying box to obtain the freeze-dried powder injection of levofloxacin hydrochloride and palmatine hydrochloride composition, vacuum stopper, out of the box, rolled aluminum cover, made 1000 antibacterial drugs .

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Abstract

The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to an antibacterial drug as well as preparation and an application thereof. The invention providesthe antibacterial drug. The antibacterial drug comprises levofloxacin hydrochloride and palmatine hydrochloride. The antibacterial drug provided by the invention is high in antibacterial effect, notonly does not enhance the drug resistance of bacteria, but also can reverse the drug resistance of CRKP.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to an antibacterial drug and its preparation and application. Background technique [0002] Klebsiella pneumoniae (KP) is one of the important opportunistic pathogens causing hospital-acquired infections, which can cause respiratory tract, urinary tract, bloodstream infection and bacteremia. At present, carbapenems are the first-line drugs for the treatment of Klebsiella pneumoniae infection, but due to widespread clinical use or even abuse, carbapenem-resistant Klebsiella pneumoniae (carbapenem-resistant K.pneumoniae, CRKP) increased significantly. CRKP is not only resistant to most β-lactam antibacterial drugs, but also resistant to antibacterial drugs that are not related to the carbapenemase resistance mechanism, resulting in extensively drug-resistant Klebsiella pneumoniae The emergence and spread of (XDR-KP) has brought great difficulties to c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4375A61K31/5383A61P31/04
CPCA61K31/4375A61K31/5383A61P31/04A61K2300/00
Inventor 姜登钊郭格格帅丽华
Owner JIUJIANG UNIVERSITY
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