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Gel sustained-release agent for treating otitis externa and preparation method thereof

A technology of otitis externa and slow-release agent, which is applied in the field of pharmaceuticals and can solve problems such as high irritation, difficulty in coating, and short drug effect time

Active Publication Date: 2020-08-07
BLOOMAGE BIOTECHNOLOGY CORP LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Aiming at the shortcomings and deficiencies of the above-mentioned prior art, the present application provides a gel sustained-release preparation for the treatment of otitis externa and its preparation method, which overcomes the shortcomings of traditional preparations such as short drug effect time, difficulty in coating, and large irritation. Disadvantages, and will not block the external auditory canal, and can absorb excess secretions, play a long-term slow-release effect, achieve long-term antibacterial effect, avoid external auditory canal stimulation caused by repeated administration, and improve patient adaptability

Method used

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  • Gel sustained-release agent for treating otitis externa and preparation method thereof
  • Gel sustained-release agent for treating otitis externa and preparation method thereof
  • Gel sustained-release agent for treating otitis externa and preparation method thereof

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preparation example Construction

[0113] The application also relates to a preparation method for the gel sustained release agent for the treatment of otitis externa, comprising the steps of:

[0114] Step 1: adding polyvinyl alcohol to purified water, and heating in a water bath until the polyvinyl alcohol is completely dissolved, to obtain an aqueous solution of polyvinyl alcohol;

[0115] Step 2: adding sodium hyaluronate into polyvinyl alcohol aqueous solution, and mixing evenly to obtain solution A;

[0116] Step 3: Add the drug-containing microcapsules, Coptidis Rhizoma extract, Phellodendron Phellodendron extract, and Forsythia extract into solution A, and mix evenly to obtain solution B;

[0117] Step 4: dissolving the preservative in the aqueous solution to obtain an aqueous solution of the preservative;

[0118] Step 5: Add the preservative aqueous solution into the solution B, and stir evenly to obtain a gel slow-release preparation for treating otitis externa.

[0119] In step 1, polyvinyl alcoho...

Embodiment 1

[0126] Add 0.2g of polyvinyl alcohol into purified water, heat in a water bath at 60°C until the polyvinyl alcohol is completely dissolved, and mix well to obtain an aqueous solution of polyvinyl alcohol; add 0.5g of sodium hyaluronate (molecular weight: 40wDa) into polyvinyl alcohol In the aqueous solution, mix evenly to obtain solution A; add 0.2 g of drug-containing microcapsules, 0.5 g of Coptidis Rhizoma extract, 1 g of Phellodendron Phellodendron extract, and 1 g of Forsythia extract to solution A, and mix evenly to obtain solution B; Dissolve 0.08g of potassium sorbate in an aqueous solution to obtain an aqueous solution of potassium sorbate; add the aqueous solution of potassium sorbate to solution B and stir evenly to obtain the gel slow-release preparation for the treatment of otitis externa, with specific parameters such as Table 1 shows.

[0127] Wherein said drug-containing microcapsule is prepared by the following method: take gelatin, add an appropriate amount o...

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Abstract

The invention discloses a gel sustained-release agent for treating otitis externa. The gel sustained-release agent comprises sodium hyaluronate, drug-containing microcapsules, a coptis chinensis extract, a phellodendron extract, a fructus forsythiae extract and polyvinyl alcohol. The invention further relates to a preparation method of the gel sustained-release agent for treating otitis externa. The invention provides the gel sustained-release preparation for treating otitis externa and the preparation method thereof, the defects of short drug effect time, difficult coating, high irritation and the like of the conventional preparations are overcome, the external auditory canal cannot be blocked, excessive secreta can be absorbed, a long-acting slow-release role can be brought into play, along-acting antibacterial effect can be achieved, external auditory canal irritation caused by repeated administration is avoided, and the patient adaptability is improved.

Description

technical field [0001] The application relates to the technical field of medicines, in particular to a gel slow-release agent for the treatment of otitis externa and a preparation method thereof. Background technique [0002] Otitis externa is one of the common diseases in otolaryngology. It is clinically manifested as: auricle traction pain, tragus tenderness or pain during chewing, ulceration of the external auditory canal and pus discharge, hearing loss, etc. Most of them are chronic non-specific inflammation of the skin and subcutaneous tissue of the external auditory canal caused by bacterial, fungal infections, or allergies. Otitis externa usually refers to diffuse otitis externa, and primary disease mainly occurs in summer and autumn, and is divided into acute otitis externa and chronic otitis externa. Acute otitis externa is mainly infiltrating inflammation, chronic otitis externa is mainly desquamation, fungal infection is also called fungal otitis externa, and mos...

Claims

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Application Information

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IPC IPC(8): A61K36/756A61K9/06A61K9/50A61K47/32A61K47/36A61K47/42A61P27/16A61P31/10A61P31/04A61K31/4174A61K31/58A61K36/634A61K36/718
CPCA61K36/718A61K36/756A61K36/634A61K31/4174A61K31/58A61K9/5057A61K9/5036A61K9/06A61K9/0046A61K47/36A61K47/32A61P27/16A61P31/10A61P31/04A61K2300/00Y02A50/30
Inventor 李超庞萌萌刘旭李敏刘建建郭学平
Owner BLOOMAGE BIOTECHNOLOGY CORP LTD
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