A joint screening test strip for early esophageal cancer

A test strip, esophageal cancer technology, applied in the field of medicine and biology, can solve problems such as less evaluation, and achieve the effects of improving detection rate, reducing mortality, high sensitivity and specificity
CN111505300BActive Publication Date: 2020-12-01THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIV
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Patent Information

Authority / Receiving Office
CN ยท China
Patent Type
Patents(China)
Current Assignee / Owner
THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIV
Publication Date
2020-12-01

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Abstract

The invention belongs to the field of medical biotechnology and discloses a test strip for joint screening of early esophageal cancer. The test strip includes a binding pad and a chromatography pad, and the binding pad is coated with a mouse anti-human IgG monoclonal antibody and a rabbit IgG monoclonal antibody. Antibodies, mouse anti-human IgG monoclonal antibody and rabbit IgG monoclonal antibody all have detectable markers; there are three detection lines and one quality control line on the chromatography pad, and the detection antigens coated on the three detection lines are KPNA6 protein, PDE1A protein, CASK protein; the quality control belt is coated with goat anti-rabbit IgG. The test strip of the present invention combines KPNA6 protein, PDE1A protein, and CASK protein, three tumor-associated antigens, as markers for early esophageal cancer screening, and is used to detect the expression levels of autoantibodies of KPNA6, PDE1A, and CASK in serum, which can effectively Detection of esophageal cancer, especially early esophageal cancer, has greatly improved the detection rate of early esophageal cancer.
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Description

technical field

[0001] The invention belongs to the technical field of medicine and biology, and in particular relates to a test strip for joint screening of early esophageal cancer. Background technique

[0002] Esophageal cancer is one of the most common malignant tumors of the digestive system in humans. The incidence of esophageal cancer ranks eighth among all malignant tumors worldwide, and its case fatality rate ranks sixth among cancer deaths. my country is a country with a high incidence of esophageal cancer in the world, and the tissue type is mainly squamous cell carcinoma (esophageal cancer in the present invention refers to esophageal squamous cell carcinoma, i.e. esophageal squamous cell carcinoma). According to the latest data from the "China Tumor Registration Annual Report" published in 2018, my country's esophageal cancer ranks sixth in the incidence of malignant tumors and fourth in death, posing a serious threat to people's quality of life and family happi...

Claims

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