Hydroxyapatite-coated magnetic drug-loaded nanoparticles, preparation method thereof and application of hydroxyapatite-coated magnetic drug-loaded nanoparticles in preparation of osteosarcoma phototherapy drugs

Abstract

The invention discloses hydroxyapatite-coated magnetic drug-loaded nanoparticles as well as a preparation method and application thereof in preparation of osteosarcoma phototherapy drugs. The hydroxyapatite-coated magnetic drug-loaded nanoparticle comprises a polydopamine magnetic nanoparticle core, and the outer side of the polydopamine magnetic nanoparticle core is sequentially coated with a drug layer and a hydroxyapatite layer; the hydroxyapatite layer is adopted to completely wrap the drug layer, loaded drugs such as a photosensitizer cannot be released in advance, and the drug targetingeffect of the magnetic drug-loaded nanoparticles is accurate and effective; the photosensitizer and other drugs do not generate optical toxic and side effects on normal tissues; hydroxyapatite can behydrolyzed in the tumor environment with the pH being about 5, then a large amount of photosensitizer is released and retained in the tumor, it is more suitable for in-vivo application. Hydroxyapatitecan promote osteoblast proliferation, kill tumor cells, sterilize and promote bone tissue repair at the same time, and three purposes are achieved at a time.

Description

technical field [0001] The invention belongs to the technical field of photodynamic therapy, and in particular relates to a hydroxyapatite-wrapped magnetic drug-carrying nanoparticle, a preparation method thereof, and an application in preparing osteosarcoma phototherapy drugs. Background technique [0002] Osteosarcoma is a common malignant bone tumor with a high incidence rate, which usually occurs in adolescents aged 10-20. The currently recognized main treatment for osteosarcoma is comprehensive treatment based on high-dose chemotherapy and surgery. Under this comprehensive treatment, the 5-year survival rate of osteosarcoma patients in my country has increased from less than 20% to 55% now. %-75%. However, the side effects of chemotherapy are obvious, the most common ones are bone marrow suppression and severe digestive system lesions. Therefore, there is a need for a method with good antitumor effect and small side effects to treat osteosarcoma. [0003] Photodynamic...

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Problems solved by technology

[0005] The deficiencies of this calcium carbonate-wrapped polydopamine drug-loaded magnetic nanoparticles and its preparation method are: (1) when ICG and calcium carbonate are adsorbed onto Fe 3 o 4 On the surface of @PDA nanoparticles, the photosensitizer ICG and Ca 2+ , CO 3 2- At the same time added to Fe 3 o 4 @PDA nanoparticle suspension, which makes calcium carbonate and ICG in the same radial direction of the magnetic nanoparticles, in the process of guiding the magnetic nanoparticles to the target, the

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