Hydroxyapatite-coated magnetic drug-loaded nanoparticles, preparation method thereof and application of hydroxyapatite-coated magnetic drug-loaded nanoparticles in preparation of osteosarcoma phototherapy drugs

A technology of magnetic nanoparticles and hydroxyapatite, which is applied in the fields of pharmaceutical formulation, drug combination, drug delivery, etc., can solve problems such as poor targeting effect, ineffective promotion of osteoblast differentiation, phototoxicity and side effects of normal tissues, etc. , to achieve the effects of easy operation, promotion of osteoblast differentiation, and accurate drug targeting
CN111558041APending Publication Date: 2020-08-21ZHEJIANG SCI-TECH UNIV
3 Cites 7 Cited by

Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
ZHEJIANG SCI-TECH UNIV
Publication Date
2020-08-21

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention discloses hydroxyapatite-coated magnetic drug-loaded nanoparticles as well as a preparation method and application thereof in preparation of osteosarcoma phototherapy drugs. The hydroxyapatite-coated magnetic drug-loaded nanoparticle comprises a polydopamine magnetic nanoparticle core, and the outer side of the polydopamine magnetic nanoparticle core is sequentially coated with a drug layer and a hydroxyapatite layer; the hydroxyapatite layer is adopted to completely wrap the drug layer, loaded drugs such as a photosensitizer cannot be released in advance, and the drug targetingeffect of the magnetic drug-loaded nanoparticles is accurate and effective; the photosensitizer and other drugs do not generate optical toxic and side effects on normal tissues; hydroxyapatite can behydrolyzed in the tumor environment with the pH being about 5, then a large amount of photosensitizer is released and retained in the tumor, it is more suitable for in-vivo application. Hydroxyapatitecan promote osteoblast proliferation, kill tumor cells, sterilize and promote bone tissue repair at the same time, and three purposes are achieved at a time.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention belongs to the technical field of photodynamic therapy, and in particular relates to a hydroxyapatite-wrapped magnetic drug-carrying nanoparticle, a preparation method thereof, and an application in preparing osteosarcoma phototherapy drugs. Background technique

[0002] Osteosarcoma is a common malignant bone tumor with a high incidence rate, which usually occurs in adolescents aged 10-20. The currently recognized main treatment for osteosarcoma is comprehensive treatment based on high-dose chemotherapy and surgery. Under this comprehensive treatment, the 5-year survival rate of osteosarcoma patients in my country has increased from less than 20% to 55% now. %-75%. However, the side effects of chemotherapy are obvious, the most common ones are bone marrow suppression and severe digestive system lesions. Therefore, there is a need for a method with good antitumor effect and small side effects to treat osteosarcoma.

[0003] Photodynamic...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More