A kind of colistin sulfate soluble powder that improves solubility and its preparation method and application

A colistin sulfate and soluble technology is applied in colistin sulfate soluble powder for improving solubility and its preparation and application field, which can solve problems such as low solubility, affecting balanced dosing of poultry and animals, and non-uniform distribution, so as to improve the Solubility, good solubility, and palatability-enhancing effects

Active Publication Date: 2022-06-24
南京大方生物工程有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the characteristics of colistin sulfate itself, its solubility is very low when it is added to water, so it cannot be evenly distributed in water, which affects the balanced administration of poultry and animals

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] 1) take 5 parts of polyethylene glycol 6000, 100 parts of distilled water and dissolve 10 parts of colistin sulfate to obtain mixture one;

[0021] 2) to mixture one, add 3 parts of polyvinylpyrrolidone PVPK30, 66 parts of lactose, 3 parts of sodium lauryl sulfate, 5 parts of disodium glycyrrhizinate, stir and dissolve, then spray-dry to obtain powdery mixture two;

[0022] 3) Add 4 parts of L-tryptophan and 4 parts of citric acid to mixture 2, and mix evenly to obtain colistin sulfate soluble powder. The polyvinylpyrrolidone PVPK30, lactose, sodium lauryl sulfate and disodium glycyrrhizinate are all in powder form. The colistin sulfate, L-tryptophan, citric acid and polyethylene glycol 6000 are all in powder form.

Embodiment 2

[0024] 1) take by weighing 6 parts of polyethylene glycol 6000, 108 parts of distilled water and dissolve 10 parts of colistin sulfate to obtain mixture one;

[0025] 2) to mixture one, add 3 parts of polyvinylpyrrolidone PVPK30, 67 parts of lactose, 3 parts of sodium lauryl sulfate, 4 parts of disodium glycyrrhizinate, stir and dissolve, then spray-dry to obtain powdery mixture two;

[0026] 3) Add 4 parts of L-tryptophan and 3 parts of citric acid to mixture 2, and mix evenly to obtain colistin sulfate soluble powder. The polyvinylpyrrolidone PVPK30, lactose, sodium lauryl sulfate and disodium glycyrrhizinate are all in powder form. The colistin sulfate, L-tryptophan, citric acid and polyethylene glycol 6000 are all in powder form.

Embodiment 3

[0028] 1) take by weighing 5 parts of polyethylene glycol 6000, 110 parts of distilled water and dissolve 10 parts of colistin sulfate to obtain mixture one;

[0029] 2) adding 3 parts of polyvinylpyrrolidone PVPK30, 67 parts of lactose, 2 parts of sodium lauryl sulfate, 5 parts of disodium glycyrrhizinate to mixture one, stirring and dissolving, then spray drying to obtain powdery mixture two;

[0030] 3) Add 4 parts of L-tryptophan and 4 parts of citric acid to mixture 2, and mix evenly to obtain colistin sulfate soluble powder. The polyvinylpyrrolidone PVPK30, lactose, sodium lauryl sulfate and disodium glycyrrhizinate are all in powder form. The colistin sulfate, L-tryptophan, citric acid and polyethylene glycol 6000 are all in powder form.

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PUM

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Abstract

The present invention relates to a kind of colistin sulfate soluble powder that improves solubility and its preparation method and application, according to the number of parts by weight, consists of 15 parts of colistin sulfate, 3-5 parts of L-tryptophan, 3-5 parts of lemon acid, 2-3 parts of polyvinylpyrrolidone PVPK30, 40-70 parts of lactose, 2-4 parts of sodium lauryl sulfate, 4-9 parts of polyethylene glycol 6000, and 4-7 parts of disodium glycyrrhizinate. Organic acids (L‑tryptophan, citric acid) act as cosolvents to increase the solubility of colistin sulfate soluble powder in water. Polyvinylpyrrolidone PVPK30 also has good solubility in water and is used as a cosolvent for acid colistin soluble powder in water. Lactose is a filler. Sodium lauryl sulfate and polyethylene glycol 6000, as solubilizers and surfactants, can also improve the solubility of colistin sulfate soluble powder in water. Disodium glycyrrhizinate is a sweetener to improve the palatability of medicines.

Description

technical field [0001] The invention relates to a soluble powder of colistin sulfate with improved solubility, a preparation method and application thereof. Background technique [0002] Colistin sulfate (polymyxin) is a group of polypeptide antibiotics produced by Paenibacillus polymyxa. It has inhibitory effect on most Gram-negative bacteria. It is insoluble in water, methanol and hexane under acidic conditions. Applicable to some gram-negative bacteria such as Escherichia coli, pneumoniae, Pseudomonas aeruginosa caused by infection. [0003] Colistin is a polypeptide antibacterial drug with a wide range of clinical applications. Colistin is usually administered by drinking water. Due to the characteristics of colistin sulfate itself, when it is added to water, its solubility is very low, so that it cannot be evenly distributed in water, which affects the balanced administration of poultry and beasts. [0004] Therefore, it is necessary to provide a colistin sulfate s...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/14A61K47/18A61K47/12A61K47/32A61K47/26A61K47/20A61K47/10A61K47/28A61K38/12A61P31/04
CPCA61K9/146A61K9/145A61K38/12A61P31/04
Inventor 汤法银
Owner 南京大方生物工程有限公司
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