A kind of high-strength chitin composite hydrogel material and its preparation method and application

A technology of compounding hydrogel and chitin, which is applied in pharmaceutical formulations, prostheses, drug delivery, etc., can solve problems such as complex methods, and achieve the effects of simple operation, low cost, and easy purification.

Active Publication Date: 2022-01-28
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the method is complex and requires the use of initiators and toxic reagents

Method used

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  • A kind of high-strength chitin composite hydrogel material and its preparation method and application
  • A kind of high-strength chitin composite hydrogel material and its preparation method and application
  • A kind of high-strength chitin composite hydrogel material and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] Embodiment 1: Preparation of high-strength chitin composite hydrogel material

[0053] Step 1: Soak chitin powder in 0.5 mol / L NaOH solution at room temperature and stir for 24 hours, then filter and wash with water for several times until the washing liquid is neutral. Then, soak the chitin powder in 0.01mol / L NaClO at 90°C 2 Stir in the solution (adjust the pH to 4 with acetic acid) for 4 h, then filter and wash with water for several times until the washing liquid is neutral. Finally, it is freeze-dried and ground to obtain purified chitin powder. At -25°C, according to the concentration of 2wt%, chitin powder was dissolved in alkaline ionic liquid (16wt% KOH, 7wt% urea), stirred for 4 hours, transferred to 4°C for 30h, and then placed at 0°C Centrifuge for 15 minutes to remove air bubbles to obtain a chitin solution.

[0054] Step 2: Melt 80 parts by mass of solid maleic anhydride at 70°C, then add 4 parts by mass of chitin powder, and 2 The reaction was stirred...

Embodiment 2

[0057] Embodiment 2: Preparation of high-strength chitin composite hydrogel material

[0058] Step 1: Soak chitin powder in 1 mol / L NaOH solution at room temperature and stir for 20 hours, then filter and wash with water for several times until the washing liquid is neutral. Then, soak the chitin powder in 0.05mol / L NaClO at 80°C 2 Stir in the solution (adjust the pH to 4 with acetic acid) for 5 h, then filter and wash with water for several times until the washing liquid is neutral. Finally, it is freeze-dried and ground to obtain purified chitin powder. At -30°C, according to the concentration of 5wt%, chitin powder was dissolved in alkaline ionic liquid (18wt% KOH, 4wt% urea), stirred for 3 hours, transferred to 6°C for 20h, and then placed at 0°C Centrifuge for 15 minutes to remove air bubbles to obtain a chitin solution.

[0059] Step 2: Melt 320 parts by mass of solid maleic anhydride at 60°C, then add 16 parts by mass of chitin powder, and 2 The reaction was stirred...

Embodiment 3

[0062] Embodiment 3: Preparation of high-strength chitin composite hydrogel

[0063] Step 1: Soak chitin powder in 2mol / L NaOH solution at room temperature and stir for 15 hours, then filter and wash with water for several times until the washing liquid is neutral. Then, soak the chitin powder in 0.25mol / L NaClO at 70°C 2 Stir in the solution (adjust the pH to 4 with acetic acid) for 3 h, then filter and wash with water for several times until the washing liquid is neutral. Finally, it is freeze-dried and ground to obtain purified chitin powder. At -35°C, according to the concentration of 8wt%, chitin powder was dissolved in alkaline ionic liquid (20wt% KOH, 5wt% urea), stirred for 2h, then transferred to 8°C for 12h, and then placed at 0°C Centrifuge for 15 minutes to remove air bubbles to obtain a chitin solution.

[0064] Step 2: Melt 150 parts by mass of solid maleic anhydride at 80°C, then add 7.5 parts by mass of chitin powder, and 2 The reaction was stirred at 100° ...

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Abstract

The invention belongs to the field of biomedical materials, and discloses a high-strength chitin composite hydrogel material, a preparation method and application thereof. The composite hydrogel material of the present invention is composed of chitin as a matrix and chitin whiskers with negatively charged surfaces as reinforcing fillers; the negatively charged chitin whiskers as reinforcing fillers are composited with the chitin matrix, and The negatively charged groups on the surface of the whiskers can form a strong electrostatic repulsion force, which can effectively promote the uniform dispersion of chitin whiskers in the chitin matrix, and at the same time achieve a good interface combination with the matrix, so as to give full play to the enhancement effect of the whiskers. Endow the chitin composite hydrogel material with excellent mechanical properties; at the same time, the chitin composite hydrogel material of the present invention has good biocompatibility and osteogenic activity, and has good application prospects in biomedical fields such as bone tissue repair .

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a high-strength chitin composite hydrogel material and its preparation method and application. Background technique [0002] Bone damage has become a common and growing problem due to trauma, genetic diseases, and progressive aging, especially bone defects caused by high-energy trauma are often accompanied by periosteal defects. Studies have shown that periosteum plays a very critical role in bone regeneration, and the absence of periosteum may impair the process of bone regeneration, resulting in prolonged healing or even non-union of bone injuries. Therefore, it is of great significance to develop an advanced periosteal biomaterial with bone repair properties. Chitin is a semi-crystalline natural polysaccharide with abundant sources. It is widely distributed in the shells of crustaceans such as shrimps and crabs. It is the second largest renewable resource on th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08L5/08C08J3/075C08J3/24C08B37/08A61L27/52A61L27/20A61L27/50
CPCC08J3/075C08J3/246C08B37/003A61L27/52A61L27/20A61L27/50C08J2305/08C08J2405/08A61L2400/00C08L5/08
Inventor 罗丙红李文彦文伟周长忍
Owner JINAN UNIVERSITY
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