[0016] The present invention will be further explained below in conjunction with the drawings:
[0017] Such as figure 1 As shown: the present invention includes a breathable tape 1, a heating pack 2, an impermeable layer 3, an impermeable ring 4, a Chinese medicine component 5 and a covering film 6. The heating pack is fixed on the lower end surface of the breathable tape, and the waterproof The permeable layer is attached to the heating pack, the impermeable ring is attached to the impermeable layer, the Chinese medicine component is filled in the middle of the impermeable ring, and the covering film is attached to the traditional Chinese medicine Components.
[0018] Specifically, the heating pack is composed of tourmaline, carbon dioxide, and salt.
[0019] Specifically, the traditional Chinese medicine components include clove, gallinarum, astragalus, evodia, dodder, amomum, atractylodes macrocephala, Cyperus rotundus, Alisma, tangerine peel, ageratum, azone, propylene glycol and petrolatum.
[0020] Preferably, the temperature rise time of the heating package of the composition is controlled within 10 minutes, the temperature is continuously controlled between 45-55°, and the required temperature is maintained for 6-8 hours.
[0021] Preferably, the traditional Chinese medicine component contains 6% of the clove, 5% of the Gallus gallus domesticus, 3% of the astragalus, 3% of the evodia, 2% of the dodder seed, and the Amomum villosum in a weight ratio. 3%, Atractylodes macrocephala 5%, Cyperus rotundus 3%, Alisma orientalis 2%, Tangerine peel 1%, Huoxiang 2%, Azone 10%, Propylene glycol 5% , The petroleum jelly is 50%.
[0022] Specifically, the preparation method of the traditional Chinese medicine component is: clove, gallinarum, astragalus, evodia, Cuscuta, Amomum villosum, Atractylodes, Cyperus rotundus, Alisma orientalis, tangerine peel, Huoxiang, mix evenly, crush, and cross 100 mesh. Sieve, melt the petrolatum in a hot water bath, add it to the powder mixture, add lauryl azemone and propylene glycol and stir to make it.
[0023] The spleen and umbilical patch has a good clinical effect, which depends on the following two aspects:
[0024] First, the composition and ratio of the medicine are excellent. The volatile oils contained in clove, Amomum villosum, Cyperus rotundus, and Evodia can play a good role in promoting penetration and treatment, which is the key to good curative effect. In the prescription, clove is pungent and warm, can reduce adverse effects in the middle, and can treat vomiting, hiccups, spleen and stomach deficiency and cold. The volatile oil of clove (eugenol, aceteugenol, eugenol, etc.) is a natural transdermal absorption enhancer. Pharmacological studies have proved that cloves can promote the secretion of gastric acid, pepsin and bile, relieve intestinal cramps, promote gastrointestinal function, relieve flatulence, enhance digestion, and relieve symptoms such as nausea, vomiting, and abdominal distension. Evodia sinensis is warm, warming the spleen and stomach but dispelling cold and evil, it is self-warming, qi is low, and all evidences are eliminated. Experimental research Evodia can promote the synthesis and release of neurotransmitter calcitonin gene-related peptide and substance P, and desensitize nerves to exert analgesic effects. Amomum villosum is pungent and warm, returning to the spleen, stomach and kidney meridian. It has the effects of dispelling dampness and appetizing, warming the spleen and stopping diarrhea. The volatile oil contained in Amomum villosum has the effects of promoting gastrointestinal peristalsis, analgesia, anti-inflammatory and antidiarrheal effects. Xiangfu is pungent, slightly bitter, slightly sweet and flat. Return to the liver, spleen, and triple jiao channel It has the functions of soothing the liver and relieving depression, regulating the qi and regulating menstruation and relieving pain. Pharmacological studies have shown that Cyperus rotundus has the effects of promoting bowel movements and analgesia. The overall formula can effectively warm the spleen, relieve pain, relieve diarrhea and relieve vomiting.
[0025] Second, the acupoint selected by the spleen-invigorating and umbilical paste is Shenque, which connects with the eight meridians of the odd meridian and the twelve meridians, and then communicates with the muscles, limbs, and official orifices. In addition, the umbilical cord is the last closed part of the abdomen during human development. It is the thinnest part of the abdomen skin, with almost no fat tissue coverage and numerous blood vessels and lymphatic vessels. After the effective molecular components of traditional Chinese medicine penetrate the skin, they can quickly diffuse into the blood and reach the whole body to play a role.
[0026] The application of acupoint application of traditional Chinese medicine, the composition of the medicine, the choice of penetration enhancer, and the site of action are important factors that affect the absorption and utilization of external medicines. The preparation of the spleen and umbilical patch of the present invention is reasonable in the choice of prescription composition and action site, but the development of the umbilical patch is limited, the active ingredients still in the medicine cannot be completely and thoroughly absorbed, and the Chinese medicine components after grinding are still coarse particles , The molecular weight is large, the dissolution rate is low, and the effective ingredients are difficult to be fully absorbed through the skin; on the other hand, ginger juice is used as a formulation, which is difficult to store, which limits the clinical application of umbilical paste to a certain extent. Therefore, improving the production process, developing transdermal penetration enhancement technology, improving curative effect, and facilitating storage on the other hand, are problems that need to be solved urgently in the development of umbilical stickers.
[0027] First: Ways to improve the penetration rate of drugs:
[0028] 1. Use penetration enhancers: such as laurin and propylene glycol, both of which can soften the stratum corneum of the skin and make it easier for the drug to pass through the skin barrier, thereby improving drug penetration; both are non-toxic and safe and can be used clinically.
[0029] 2. With far-infrared materials: far-infrared materials can increase the temperature of the umbilical paste after contacting the skin. On the one hand, it can promote the exudation of the volatile oil of traditional Chinese medicine. On the other hand, the temperature rises and the vasodilation promotes the absorption of the drug. Utilization rate.
[0030] Tourmaline is a natural ore with permanent electrodes, which can be used as the main component of far-infrared materials. Tourmaline can emit far-infrared rays, promote drug penetration, and stimulate meridian points. Therefore, it can be combined with the traditional manufacturing process of the spleen and umbilical paste to improve the traditional spleen and umbilical paste.
[0031] Tourmaline, also known as tourmaline, has a complex chemical composition and the mineralogical name tourmaline. After a large number of scientific researches, Tourmaline has four special properties, namely, emission of far infrared rays, release of negative ions, bioelectricity, and minerals. Substances and trace elements. The first feature, emission of far-infrared rays: Under certain temperature conditions, Tourmaline can emit far-infrared rays with a wavelength of 4~14um. This wavelength matches the wavelength of the human body’s far-infrared absorption and radiation, so as to make the human skin temperature Increased blood flow speeds up, thereby improving microcirculation. The second feature is the release of negative ions: Tourmaline is known as the "natural negative ion generator", which can automatically and permanently release negative ions to neutralize free radicals, further activate cells and reduce fatigue. The third characteristic, bioelectricity: The bioelectricity produced by tourmaline is 0.06mA, which is similar to the bioelectricity of the human body. When this bioelectricity acts on the meridians and acupoints of the human body, it will cause the biological effect of the bioelectricity of the human body and promote The human body balances yin and yang, relaxes tendons and collaterals, promotes blood circulation and removes blood stasis, so it has a beneficial effect on promoting metabolism, regulating the nervous system, and improving blood circulation, thereby achieving the effect of preventing and treating diseases. The fourth feature is rich in trace elements and promotes human health.
[0032] Second: Extend storage time: Use medical white Vaseline instead of ginger juice to prepare traditional Chinese medicine. Vaseline is an odorless ointment-like substance. It is not hydrophilic and will not be absorbed, so it can form a layer on the skin surface. The protective film keeps the part in a closed state, which not only blocks the chance of external pathogenic bacteria from contacting the skin, but also prevents the moisture from evaporating and losing. The skin can maintain a long-term moist state. Under the hydration of the skin, the medicine is also more effective. Easy to absorb.
[0033] In summary, the traditional manufacturing process of the spleen-invigorating and umbilical paste has the problem of low drug utilization and difficult storage. The use of penetration enhancers and petroleum jelly can promote drug penetration, improve the efficacy, and is easy to store. The combination of technology, penetration enhancer, far-infrared material tourmaline, etc. to develop a new spleen and umbilical patch will be able to better serve the clinic, which is of great significance.
[0034] Clinical verification of the spleen and umbilical patch of the present invention:
[0035] Collect 100 pediatric outpatient cases, aged 6 months to 14 years, diagnosed as children with diarrhea, and dialectical diagnosis of cold and dampness in the spleen. According to the random number table, they are divided into observation group and control group with 50 cases each Both groups were given conventional treatments such as antidiarrheal, fluid supplementation, and intestinal flora regulation. The observation group was given new spleen-invigorating and umbilical paste treatment, and the control group was given traditional spleen-invigorating and umbilical paste treatment. Observe the relief of diarrhea symptoms after the comparative medication, adverse reactions and symptoms during use, the preservation of the umbilical paste, etc., and the preservation of the new spleen-invigorating and umbilical paste for 6 months.
[0036] Through clinical verification, the new type of umbilical paste was improved in terms of drug ratio and heating index to improve the efficacy and ease of use.
[0037] The results of diarrhea recovery time are as follows:
[0038] project 6 months 1-2 years old 3-6 years old 6-10 years old 10-14 years old Observation group 4-6 hours 5-7 hours 6-7 hours 7-9 hours 8-12 hours Control group 10-12 hours 10-14 hours 12-16 hours 15-20 hours 16-24 hours
[0039] Diagnosis criteria: Refer to the "Criteria for Diagnosis and Efficacy of Diseases and Syndromes in Traditional Chinese Medicine" (ZY/T001.4-94), the industry standard of the People's Republic of China.
[0040] (1) Stools are thin or watery, increasing the frequency. Can be accompanied by abdominal distension and abdominal pain.
[0041] (2) Acute diarrhea has a sudden onset and a short course. May be accompanied by chills, fever and other symptoms.
[0042] (3) Chronic chronic diarrhea has a slow onset, a longer course, recurring attacks, sometimes mild and sometimes severe.
[0043] (4) Improper diet, cold or mood changes can be induced.
[0044] (5) A few red and white blood cells can be seen routinely in stool, and stool culture is positive or negative for pathogenic bacteria.
[0045] (6) If necessary, perform X-ray barium enema or fiber enteroscopy.
[0046] Syndrome classification
[0047] Cold dampness and sleepy spleen: stools are clear or watery, abdominal pain and bowel irritation, chills and less food. The moss is white and slippery, and the pulse is slow.
[0048] Inclusion criteria: Children with age distribution ranging from 6 months to 14 years, diagnosed as children with diarrhea, dialectically as children with cold, dampness and spleen.
[0049] Exclusion criteria: 1) Severe diseases such as severe pneumonia, severe central nervous system infection, etc. occurred during the follow-up period; 2) Children with fever dialectically.
[0050] Fall-off criteria: Those who were not followed up for various reasons after being included.
[0051] Intervention method
[0052] Both groups were treated with conventional treatments such as antidiarrheal, fluid supplementation, and intestinal flora adjustment. The observation group was given a new type of spleen-invigorating and umbilical patch for 6-8 hours, and the control group was given traditional spleen-and-umbilical patching for Shenque 6 -8 hours.
[0053] Observation index
[0054] 1) Relief of diarrhea symptoms after medication;
[0055] 2) Drug allergies and burns during medication;
[0056] 3) The two kinds of spleen-invigorating and umbilical pastes deteriorated and dried out during the storage period, and the new umbilical paste was placed and observed for 6 months.
[0057] Efficacy determination
[0058] Refer to the Chinese medicine industry standard of the People's Republic of China "Standards for Diagnosis and Efficacy of TCM Diseases and Syndromes" (ZY/T001.4-94).
[0059] Cure: Stool is normal, other symptoms disappear, and clinical examination is normal.
[0060] Improvement: The frequency of bowel movements is significantly reduced, and other symptoms are improved.
[0061] Unhealed: No improvement in symptoms.
[0062] Improvement of new spleen and umbilical paste
[0063] Through clinical verification, the new type of umbilical paste was improved in terms of drug ratio and heating index to improve the efficacy and ease of use.
[0064] The above shows and describes the basic principles and main features of the present invention and its advantages. Those skilled in the industry should understand that the present invention is not limited by the foregoing embodiments. The foregoing embodiments and descriptions only illustrate the principles of the present invention. Without departing from the spirit and scope of the present invention, the present invention may have Various changes and improvements, these changes and improvements fall within the scope of the claimed invention. The scope of protection claimed by the present invention is defined by the appended claims and their equivalents.
