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Pharmaceutical composition for preventing and treating atherosclerosis as well as preparation method and application method thereof

A technology of atherosclerosis and composition, which is applied in the field of pharmaceutical compositions for the prevention and treatment of atherosclerosis, can solve the problems of complex pathogenesis of atherosclerosis, difficulty in obtaining significant curative effect, and numerous lesion targets, and achieves a suitable The effect of clinical application, no toxic and side effects, and simple preparation method

Inactive Publication Date: 2020-09-18
GUANGZHOU BAIYUNSHAN PHARMA HLDG CO LTD BAIYUNSHAN PHARMA GENERAL FACTORY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the pathogenesis of atherosclerosis is complex and there are many disease targets. It is generally difficult for drugs with a single target to achieve significant curative effects. Some drugs also have disadvantages such as large side effects, and there are large unmet clinical needs

Method used

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  • Pharmaceutical composition for preventing and treating atherosclerosis as well as preparation method and application method thereof
  • Pharmaceutical composition for preventing and treating atherosclerosis as well as preparation method and application method thereof
  • Pharmaceutical composition for preventing and treating atherosclerosis as well as preparation method and application method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] A pharmaceutical composition, which is prepared by parts by weight, comprising the bulk drug of the following components:

[0050]

[0051]

[0052] The preparation method of described pharmaceutical composition comprises the following steps:

[0053] Grind Danshen, alum, angelica, and cinnamon into fine powder; add Guanzhong, Polygonum cuspidatum, Polygonum multiflorum, Shayuanzi, ginseng, pomegranate peel, ephedra and other seven flavors to 8 times of water and decoct twice, the first time for 3.5 hours, and the second time for 1.5 hours , combined decoction, filtered, the filtrate was concentrated into a thick paste, added the above fine powder, mixed, dried at 95°C, crushed into powder, and sieved to obtain.

[0054] A pharmaceutical composition for preventing and treating atherosclerosis, the preparation method of which comprises the following steps:

[0055] (1) mixing the above-mentioned pharmaceutical composition with the pharmaceutical excipient;

[005...

Embodiment 2

[0059] A pharmaceutical composition, which is prepared by parts by weight, comprising the bulk drug of the following components:

[0060]

[0061]

[0062] The preparation method of described pharmaceutical composition comprises the following steps:

[0063] Grind salvia, alum, angelica, and cinnamon into fine powder; add Guanzhong, Polygonum cuspidatum, Polygonum multiflorum, Shayuanzi, ginseng, pomegranate peel, ephedra and other seven flavors with 12 times of water and decoct twice, the first time for 2.5 hours, and the second time for 1.5 hours , combined decoction, filtered, the filtrate was concentrated into a thick paste, added the above fine powder, mixed, dried at 80 ° C, crushed into powder, and sieved.

[0064] A pharmaceutical composition for preventing and treating atherosclerosis, the preparation method of which comprises the following steps:

[0065] (1) mixing the above-mentioned pharmaceutical composition with the pharmaceutical excipient;

[0066] (2)...

Embodiment 3

[0069] A pharmaceutical composition, which is prepared by parts by weight, comprising the bulk drug of the following components:

[0070]

[0071] The preparation method of described pharmaceutical composition comprises the following steps:

[0072] Grind Danshen, alum, angelica, and cinnamon into fine powder; add Guanzhong, Polygonum cuspidatum, Polygonum multiflorum, Shayuanzi, ginseng, pomegranate peel, ephedra and other seven flavors with 10 times of water and decoct twice, the first time for 5 hours, and the second time for 1.5 hours , Combine the decoction, filter, concentrate the filtrate into a thick paste, add the above-mentioned fine powder, mix well, dry at 70°C, crush into powder, and sieve.

[0073] A pharmaceutical composition for preventing and treating atherosclerosis, the preparation method of which comprises the following steps:

[0074] (1) mixing the above-mentioned pharmaceutical composition with the pharmaceutical excipient;

[0075] (2) according to...

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Abstract

The invention relates to a pharmaceutical composition for preventing and treating atherosclerosis as well as a preparation method and application method thereof. The composition comprises the following components: cyrtomium rhizome, rhizoma polygoni cuspidati, radix polygoni multiflori, radix salviae miltiorrhizae, white alum, radix angelicae sinensis, semen astragali complanati, radix ginseng, pericarpium granati, herba ephedra and cortex cinnamomi. The pharmaceutical composition containing the composition can obviously improve the blood lipid level of a New Zealand rabbit model with the atherosclerosis, reduce inflammatory factor release and relieve myocardial damage, and is suitable for prevention and treatment of the atherosclerosis.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to a pharmaceutical composition for preventing and treating atherosclerosis and a preparation and application method thereof. Background technique [0002] Arteriosclerosis is a non-inflammatory disease of the arteries. It is a general term for degenerative and proliferative lesions in which the arterial wall thickens, hardens, loses elasticity, and narrows the lumen. There are 3 types of arteriosclerosis. Among them, atherosclerosis (AS) is a common type of arteriosclerosis, and it is the initiating link and pathological basis of coronary heart disease, cerebral infarction, peripheral vascular disease and other diseases that seriously threaten human health. [0003] The "China Cardiovascular Disease Report 2018" compiled by the National Center for Cardiovascular Diseases shows that the number of patients with cardiovascular diseases in my country is about 290 million, a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/704A61P9/10A23L33/105A23L33/16A61K33/06
CPCA23V2002/00A61K33/06A61K36/12A61K36/17A61K36/185A61K36/232A61K36/258A61K36/481A61K36/537A61K36/54A61K36/704A61K2236/331A61K2236/53A23L33/105A23L33/16A61P9/10A61K2300/00A23V2200/326A23V2250/21A23V2250/1564A23V2250/16
Inventor 罗志波王玮张琳鲍颖霞王健松
Owner GUANGZHOU BAIYUNSHAN PHARMA HLDG CO LTD BAIYUNSHAN PHARMA GENERAL FACTORY
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