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Harmine gastrointestinal tract adhesive tablet and preparation method thereof

A technology for dehydrocamelin and adhesive tablets, which is applied in the directions of pharmaceutical formulations, medical preparations with inactive ingredients, and medical preparations containing active ingredients, etc., can solve problems such as low drug bioavailability, and achieve improved drug dissolution. The effect of speed, shortening of disintegration time, and stable release

Active Publication Date: 2020-09-25
SICHUAN ACADEMY OF MEDICAL SCI SICHUAN PROVINCIAL PEOPLES HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Aiming at the above-mentioned prior art, the present invention provides a hazaline gastrointestinal tract adhesive tablet and a preparation method thereof, so as to solve the problem of drug biology in the existing tablet. The problem of low utilization

Method used

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  • Harmine gastrointestinal tract adhesive tablet and preparation method thereof
  • Harmine gastrointestinal tract adhesive tablet and preparation method thereof
  • Harmine gastrointestinal tract adhesive tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] A dehydrohaeline gastrointestinal tract adhesive tablet, comprising the following components in mass percentage:

[0038] Dehydrohaeline 34.5%, chitosan (relative molecular mass about 10000) 10%, spray-dried lactose 18.5%, hydroxypropyl methylcellulose (HPMC Kl5M ) 10%, microcrystalline cellulose (MCC, about 100 degree of polymerization) 7%, magnesium stearate 10% and micropowder silica gel 10%.

[0039] The gastrointestinal tract adhesive sheet in this embodiment is made through the following steps:

[0040] S1: Uniformly mix dehydrohaeline, chitosan and spray-dried lactose and pass through a 100-mesh sieve, then add microcrystalline cellulose passed through a 25-mesh sieve, mix well, and dry at 48°C for 2 hours to obtain a dry powder;

[0041] S2: HPMC Kl5M , magnesium stearate and micropowder silica gel are uniformly mixed and passed through a 100m mesh sieve, and the sieve is mixed with dry powder to obtain a tablet mixture;

[0042] S3: The tablet mixture was pl...

Embodiment 2

[0044] A dehydrohaeline gastrointestinal tract adhesive tablet, comprising the following components in mass percentage:

[0045] Dehydrohaeline 35%, chitosan (relative molecular mass about 10000) 12%, spray-dried lactose 20%, hydroxypropyl methylcellulose (HPMC Kl5M ) 8%, microcrystalline cellulose (MCC, about 100 degree of polymerization) 8%, magnesium stearate 8% and micropowder silica gel 9%.

[0046] The gastrointestinal tract adhesive sheet in this embodiment is made through the following steps:

[0047] S1: uniformly mix dehydrohaeline, chitosan and spray-dried lactose and pass through a 100-mesh sieve, then add microcrystalline cellulose passed through a 25-mesh sieve, mix well, and dry at 45°C for 3 hours to obtain a dry powder;

[0048] S2: HPMC Kl5M , magnesium stearate and micropowder silica gel are uniformly mixed and passed through a 100m mesh sieve, and the sieve is mixed with dry powder to obtain a tablet mixture;

[0049]S3: Put the tableting mixture in a pu...

Embodiment 3

[0051] A dehydrohaeline gastrointestinal tract adhesive tablet, comprising the following components in mass percentage:

[0052] Dehydrohaeline 30%, chitosan (relative molecular mass about 10000) 10%, spray-dried lactose 20%, hydroxypropyl methylcellulose (HPMC Kl5M ) 10%, microcrystalline cellulose (MCC, about 100 degree of polymerization) 10%, magnesium stearate 10% and micropowder silica gel 10%.

[0053] The gastrointestinal tract adhesive sheet in this embodiment is made through the following steps:

[0054] S1: Uniformly mix dehydrohaeline, chitosan and spray-dried lactose and pass through a 100-mesh sieve, then add microcrystalline cellulose passed through a 25-mesh sieve, mix well, and dry at 50°C for 1 hour to obtain a dry powder;

[0055] S2: HPMC Kl5M , magnesium stearate and micropowder silica gel are uniformly mixed and passed through a 100m mesh sieve, and the sieve is mixed with dry powder to obtain a tablet mixture;

[0056] S3: Put the tableting mixture in ...

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Abstract

The invention discloses a harmine gastrointestinal tract adhesive tablet and a preparation method thereof. The adhesive tablet comprises the following components in percentage by mass: 30-35% of harmine, 10-12% of chitosan, 15-20% of lactose, 8-10% of an adhesive, 5-8% of an excipient, 8-10% of a lubricant and 8-10% of a flow aid. The preparation method comprises the following steps of firstly, uniformly mixing the harmine, the chitosan and the lactose, adding the excipient, and performing drying to obtain dry powder; secondly, uniformly mixing the adhesive, the lubricant and the flow aid, anduniformly mixing a mixture with the dry powder to obtain a tabletting mixture; and finally, putting the tabletting mixture into a tabletting device, and pressing the mixture under the pressure of 40-60 N to obtain the harmine gastrointestinal tract adhesive tablet. The obtained adhesive tablet has relatively high release rate and adhesive force, can be stably adhered to the gastrointestinal tracts and stably releases medicinal components after being taken, and has a relatively good effect on treatment of echinococcosis.

Description

technical field [0001] The invention relates to an intestinal tract adhesive tablet, in particular to a dehydrohalamine gastrointestinal tract adhesive tablet and a preparation method thereof. Background technique [0002] Echinococcosis is a global public health problem, and the incidence rate in my country shows an overall upward trend year by year. The distribution of echinococcosis is related to the region and is easily restricted by geographical location, climate and traffic conditions. At present, surgery is the first choice for this disease, but the intraoperative infection is high and the postoperative recurrence rate is high. Drug treatment can effectively reduce the recurrence rate and improve the surgical cure rate. The current preferred and preventive drug against echinococcosis is albendazole. But albendazole has poor absorption, low bioavailability, unsatisfactory shortcoming of cure rate and relapse rate after treatment. [0003] Dehydrohalamine has antiba...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/22A61K31/437A61K47/38A61K47/36A61K47/26A61K47/04A61P33/10A61K31/7016
CPCA61K31/437A61K31/7016A61K9/205A61K9/2018A61K9/2054A61K9/2009A61K9/0065A61K9/2095A61P33/10A61K2300/00Y02A50/30
Inventor 廖治尹琪楠韩丽珠白兰童荣生
Owner SICHUAN ACADEMY OF MEDICAL SCI SICHUAN PROVINCIAL PEOPLES HOSPITAL
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