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A kind of electrodialysis extraction method of n-acetyl-l-cysteine

A technology of cysteine ​​and extraction method, which is applied in the field of amino acid derivative production, can solve the problems of environmental pollution, complicated operation, and low extraction rate, and achieve the effects of reducing environmental pollution, reducing the amount of activated carbon, and improving the extraction rate of products

Active Publication Date: 2022-02-18
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to provide a method for separating and extracting N-acetyl-L-cysteine ​​from the electrolytic reaction solution by means of electrodialysis, so as to overcome the high cost of the traditional separation method, complicated operation, low extraction rate, and easy environmental pollution. lack of pollution

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  • A kind of electrodialysis extraction method of n-acetyl-l-cysteine
  • A kind of electrodialysis extraction method of n-acetyl-l-cysteine
  • A kind of electrodialysis extraction method of n-acetyl-l-cysteine

Examples

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Effect test

Embodiment 1

[0030] Take 2L of the electrolytic reaction solution, add hydrochloric acid to adjust the pH to 2, filter through a ceramic filter membrane to remove solid impurities, the operating pressure is 0.3MPa, and the temperature is 30°C. Then, inject the filtered clear liquid into the dilute chamber of the electrodialysis membrane separator, add 4L tap water to the concentrated chamber, set the operating voltage of the electrodialysis equipment to 5V, the temperature is 30°C, and run for 4h to obtain N-acetyl-L-cysteine ​​desalination solution . Raise the temperature of the electrodialysis desalination solution to 60°C, stir vigorously, add decolorizing activated carbon, and keep warm for 60 minutes to decolorize. Then the decolorized supernatant is concentrated through a reverse osmosis membrane until the content of N-acetyl-L-cysteine ​​is 15%, to obtain a reverse osmosis pre-concentrate. The obtained reverse osmosis pre-concentrate was evaporated and concentrated under reduced pr...

Embodiment 2

[0032]Take 2L of the electrolytic reaction solution, add hydrochloric acid to adjust the pH to 2, filter through a ceramic filter membrane to remove solid impurities, the operating pressure is 0.3MPa, and the temperature is 30°C. Then, inject the filtered clear liquid into the dilute chamber of the electrodialysis membrane separator, add 4L of tap water to the concentrated chamber, set the operating voltage of the electrodialysis equipment to 10V, and the temperature to 30°C for 2.5h to obtain N-acetyl-L-cysteine ​​desalination liquid. Raise the temperature of the electrodialysis desalination solution to 60°C, stir vigorously, add decolorizing activated carbon, and keep warm for 60 minutes to decolorize. Then the decolorized supernatant is concentrated through a reverse osmosis membrane until the content of N-acetyl-L-cysteine ​​is 15%, to obtain a reverse osmosis pre-concentrate. The obtained reverse osmosis pre-concentrate was evaporated and concentrated under reduced press...

Embodiment 3

[0034] Take 2L of the electrolytic reaction solution, add hydrochloric acid to adjust the pH to 2, filter through a ceramic filter membrane to remove solid impurities, the operating pressure is 0.3MPa, and the temperature is 30°C. Then, inject the filtered supernatant into the dilute chamber of the electrodialysis membrane separator, add 4L tap water to the concentrated chamber, set the operating voltage of the electrodialysis equipment to 20V, the temperature is 30°C, and run for 1.5h to obtain N-acetyl-L-cysteine ​​desalination liquid. Raise the temperature of the electrodialysis desalination solution to 60°C, stir vigorously, add decolorizing activated carbon, and keep warm for 60 minutes to decolorize. Then the decolorized supernatant is concentrated through a reverse osmosis membrane until the content of N-acetyl-L-cysteine ​​is 15%, to obtain a reverse osmosis pre-concentrate. The obtained reverse osmosis pre-concentrate was evaporated and concentrated under reduced pre...

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Abstract

The invention belongs to the technical field of amino acid production and discloses an electrodialysis extraction method of N-acetyl-L-cysteine. The present invention adopts the combination of ceramic membrane separation, electrodialysis desalination, activated carbon decolorization, membrane concentration, decompression evaporation concentration crystallization and recrystallization process to effectively realize the clean and efficient production of N-acetyl-L-cysteine; The key point is to replace the traditional desalination and concentration extraction processes such as ion exchange and organic solvent extraction with electrodialysis; it greatly improves the product extraction rate and product purity, and at the same time reduces the acid and alkali consumption and water consumption of the original process, reducing the follow-up process. The amount of activated carbon used in the process greatly reduces environmental pollution.

Description

technical field [0001] The invention belongs to the technical field of amino acid derivative production, and particularly relates to an electrodialysis extraction method of N-acetyl-L-cysteine, which has important applications in the purification fields of medicine, cosmetics and biochemical raw materials. [0002] technical background [0003] N-acetyl-L-cysteine ​​(NAC) is an acetylated derivative of cysteine, which has extremely high medicinal value. Its molecule contains a sulfhydryl group, which can break the disulfide bond in the peptide bond of mucin, It is widely used in the treatment of respiratory diseases, and can also be made into eye drops to treat various keratitis. At the same time, the sulfhydryl group of N-acetyl-L-cysteine ​​can interact with oxidative groups, which can be used to treat, prevent or delay hair loss due to oxidative damage or chemotherapy; it can participate in various important metabolisms, and can promote glutathione The synthesis of peptid...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C323/59C07C319/28
CPCC07C319/28
Inventor 林海波丛林川
Owner JILIN UNIV