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Zein composite medical dressing as well as preparation method and application thereof
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A technology of zein and zein, applied in medical science, absorbent pads, bandages, etc., can solve the problems of inability to isolate microorganisms, difficult to remove, poor flexibility, etc., and achieve the effects of mass production, less infection, and mild conditions
Inactive Publication Date: 2020-10-02
SHANGHAI JIAO TONG UNIV +1
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However, if the permeability is too high, it is easy to dehydrate the wound surface; and because it cannot isolate microorganisms, it is easy to cause cross-infection; in addition, it is easy to stick to the wound surface and is difficult to remove
New dressings (such as: carrageenan, alginate, chitosan, collagen and its composite materials, etc.), including film, foam, hydrogel, colloid, etc., have excellent blood and exudateabsorption capacity, can Prevent cross-infection caused by microbial invasion, but poor flexibility is the biggest disadvantage of these dressings
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Embodiment 1
[0029] The zein composite medical dressing is made of the following raw materials in parts by mass: 10 g of zein and 0.2 g of polyacrylic acid.
[0030] The preparation method of the zein composite medical dressing of the present embodiment, the steps are as follows:
[0031] Zein and polyacrylic acid were respectively dissolved in a mixed solution of 100 mL of ethanol and water, and the concentration of ethanol was 55% by volume. After mixing, it was left to dry at a constant temperature of 20°C. The zein composite medical dressing material was prepared.
Embodiment 2
[0033] The zein composite medical dressing is made of the following raw materials in parts by mass: 0.2 g of zein and 10 g of polyacrylic acid.
[0034] The preparation method of the zein composite medical dressing of the present embodiment, the steps are as follows:
[0035] Zein and polyacrylic acid were respectively dissolved in a mixed solution of 100 mL of ethanol and water, and the concentration of ethanol was 55% by volume. After mixing, the zein composite medical dressing material is obtained by standing and drying at a constant temperature of 20°C.
[0036] The zein composite medical dressing prepared in this example was tested for water absorption. The water absorption of the zein composite medical dressing prepared in this example was 5 times its own dry weight, and the stretch ratio was 2 times the length of the original film.
[0037] figure 1 It is the photo of the zein composite medical dressing actual figure (A) and water absorption (B) prepared by the presen...
Embodiment 3
[0039] The zein composite medical dressing is made of the following raw materials in parts by mass: 1 g of zein, 1 g of polyacrylic acid, and 0.1 g of polyvinylpyrrolidone.
[0040] The preparation method of the zein composite medical dressing of the present embodiment, the steps are as follows:
[0041] Zein and polyacrylic acid were respectively dissolved in a mixed solution of 100 mL of ethanol and water, and the concentration of ethanol was 55% by volume. Freeze dry after mixing. Then, add 100 mL of the mixed solution of ethanol and water containing polyvinylpyrrolidone, and the concentration of ethanol is 55% by volume. The zein composite medical dressing material was prepared by freeze-drying and forming a film.
[0042] The water absorption of the zein composite medical dressing prepared in this example is 2 times of its own dry weight, and the stretching ratio is 5 times of the original film length.
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Abstract
The invention relates to a zein composite medical dressing as well as a preparation method and application thereof. The zein composite medical dressing is a film mainly composed of zein (2-98% in parts by mass), polyacrylic acid (2-98% in parts by mass), and polyvinylpyrrolidone (0-96% in parts by mass). The water absorption of the zein composite medical dressing is 2-80 times the dry weight of the film, and the stretching ratio is 1-5 times the original film length. The preparation method of the zein composite medical dressing comprises the following steps: dissolving the zein and the polyacrylic acid in a mixed solution of ethanol and water respectively, wherein the volume percentage of the ethanol is 55-95%; after mixing of the zein and the polyacrylic acid, performing constant-temperature standing drying or freeze drying at 20-50 DEG C; then adding a mixed solution, containing polyvinylpyrrolidone, of ethanol and water, wherein the volume percentage of the ethanol is 55-95%; and performing constant-temperature standing drying or freeze drying at 20-50 DEG C form a film to prepare the zein composite medical dressing. The zein composite medical dressing can be used for wound hemostasis and tissue repair.
Description
technical field [0001] The invention belongs to the technical field of medical wound dressings, and in particular relates to zein composite medical dressings and a preparation method and application thereof. Background technique [0002] After the body is injured and formed a wound, it needs to be treated professionally. Improper treatment can cause infection, failure to heal, and scar formation. An ideal wound dressing can not only stop bleeding, but also effectively promote the repair and regeneration of damaged tissue. [0003] There are many types of wound dressings available, each with its own advantages and disadvantages. Traditional dressings (such as gauze made of natural or synthetic fibers) are cheap, can quickly absorb blood and wound exudate, and are simple to process. However, if the permeability is too high, it is easy to dehydrate the wound surface; and because it cannot isolate microorganisms, it is easy to cause cross-infection; in addition, it is easy to ...
Claims
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Application Information
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