Raw material screening method for paclitaxel production

A screening method and paclitaxel technology are applied in the directions of cleaning methods using liquids, chemical instruments and methods, cleaning methods and utensils, etc., which can solve the problems of affecting extraction effect, unsatisfactory effect, complicated screening effect, etc., so as to improve the bactericidal effect, The effect of improving cleaning efficiency

Active Publication Date: 2020-10-13
无锡紫杉药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Aiming at the deficiencies in the prior art, the present invention provides a method for screening raw materials for paclitaxel production, mainly to solve the problem that there are often many impurities in the raw materials. If they cannot be processed and screened, the extraction effect in the later stage will be affected. The screening effect is relatively complicated and the effect is not ideal, which cannot meet people's requirements

Method used

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  • Raw material screening method for paclitaxel production

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] refer to figure 1 , a raw material screening method for paclitaxel production, comprising the following steps:

[0033] S1: Prepare raw materials, prepare the whole Northeast yew tree, and then perform peeling treatment to distinguish the yew bark, branches and leaves;

[0034] S2: branch cutting, cutting the stripped bark and branches;

[0035] S3: Screening raw materials, removing unqualified bark and branches with insects or corrosion with a knife to prevent unqualified raw materials from polluting paclitaxel during the extraction process and affecting the normal efficacy of the drug;

[0036] S4: Clean the raw materials, put the raw materials to be processed in water, and then dry them naturally, then repeat the cleaning once, and then dry them again to prevent insect eggs or dust invisible to the naked eye from adhering to the raw materials, and then crush them later. The added ethanol will be polluted during the extraction, which will affect the normal reaction;...

Embodiment 2

[0044] refer to figure 1 , a raw material screening method for paclitaxel production, comprising the following steps:

[0045] S1: Prepare raw materials, prepare the whole Northeast yew tree, and then perform peeling treatment to distinguish the yew bark, branches and leaves;

[0046] S2: branch cutting, cutting the stripped bark and branches;

[0047] S3: Screening raw materials, removing unqualified bark and branches with insects or corrosion with a knife to prevent unqualified raw materials from polluting paclitaxel during the extraction process and affecting the normal efficacy of the drug;

[0048] S4: Clean the raw materials, put the raw materials to be processed in water, and then dry them naturally, then repeat the cleaning once, and then dry them again to prevent insect eggs or dust invisible to the naked eye from adhering to the raw materials, and then crush them later. The added ethanol will be polluted during the extraction, which will affect the normal reaction;...

Embodiment 3

[0056] refer to figure 1 , a raw material screening method for paclitaxel production, comprising the following steps:

[0057] S1: Prepare raw materials, prepare the whole Northeast yew tree, and then perform peeling treatment to distinguish the yew bark, branches and leaves;

[0058] S2: branch cutting, cutting the stripped bark and branches;

[0059] S3: Screening raw materials, removing unqualified bark and branches with insects or corrosion with a knife to prevent unqualified raw materials from polluting paclitaxel during the extraction process and affecting the normal efficacy of the drug;

[0060] S4: Clean the raw materials, put the raw materials to be processed in water, and then dry them naturally, then repeat the cleaning once, and then dry them again to prevent insect eggs or dust invisible to the naked eye from adhering to the raw materials, and then crush them later. The added ethanol will be polluted during the extraction, which will affect the normal reaction;...

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Abstract

The invention relates to the technical field of paclitaxel production and discloses a raw material screening method for paclitaxel production. The raw material screening method includes the followingsteps that S1, raw materials are prepared, wherein a whole taxus cuspidata tree is prepared, then peeling treatment is conducted, and taxus cuspidata bark, branches and leaves are distinguished; S2, branch segmentation is conducted, wherein the peeled bark and branches are segmented; S3, raw material screening is conducted, wherein the bark and branches which are not qualified due to worm damage or corrosion are removed through a tool; and S4, raw material cleaning is conducted. By means of the raw material screening method for paclitaxel production, impurities such as weed, bird dung and hives on raw materials can be separated out during raw material treatment, normal extracting work is prevented from being affected by the impurities, in addition, when large-diameter branches are completely subjected to peeling treatment, influences of xylem on the extracting work is prevented, the raw materials can be sufficiently smashed through two times of smashing, then a screen is used for screening, and it is ensured that the smashed raw materials meet the paclitaxel extracting requirement.

Description

technical field [0001] The invention relates to the technical field of paclitaxel production, in particular to a method for screening raw materials for paclitaxel production. Background technique [0002] Paclitaxel is a natural secondary metabolite isolated and purified from the bark of the gymnosperm plant Taxus chinensis. It has been clinically verified to have good anti-tumor effects, especially for ovarian cancer, uterine cancer and breast cancer, which have a high incidence of cancer. There are special effects. Paclitaxel is the most popular anticancer drug in the international market in recent years. It is considered to be one of the most effective anticancer drugs for human beings in the next 20 years, with a broad market. [0003] The most common raw material for paclitaxel in my country is Taxus chinensis. Generally, the raw material must be processed before extraction, such as peeling and cutting. However, many times there are many impurities in the raw material....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B02C21/00B02C23/08B02C23/16B08B3/10F26B9/10A61L2/08C07D305/14
CPCA61L2/084B02C21/00B02C23/08B02C23/16B08B3/102C07D305/14F26B9/10
Inventor 葛月兰文佺佺高杰
Owner 无锡紫杉药业股份有限公司
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