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Hydrogel dressing, preparation method thereof, multifunctional nano-composite dressing, and preparation method and application of multifunctional nano-composite dressing

A nanocomposite and hydrogel technology, which is applied in the fields of pharmaceutical formulation, medical science, drug delivery, etc., can solve problems such as difficult to achieve satisfactory results, single functionality, and difficult to cover the full-cycle antibacterial performance of wound repair. Achieve the effect of making up for poor antibacterial effect, overcoming single function, and good biocompatibility

Inactive Publication Date: 2020-10-16
CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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  • Description
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Problems solved by technology

[0006] The present invention aims to solve the technical problems that gel dressings used in the prior art usually have single functions, are difficult to cover the whole cycle of wound repair, and have weak antibacterial properties, and are difficult to achieve satisfactory results, and provide a hydrogel dressing Its preparation method and multifunctional nanocomposite dressing and its preparation method and application

Method used

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  • Hydrogel dressing, preparation method thereof, multifunctional nano-composite dressing, and preparation method and application of multifunctional nano-composite dressing
  • Hydrogel dressing, preparation method thereof, multifunctional nano-composite dressing, and preparation method and application of multifunctional nano-composite dressing
  • Hydrogel dressing, preparation method thereof, multifunctional nano-composite dressing, and preparation method and application of multifunctional nano-composite dressing

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preparation example Construction

[0063] The present invention also provides a preparation method of multifunctional nanocomposite dressing, comprising the following steps:

[0064] Step 1, synthesizing photothermal nanomaterials;

[0065] Step 2, loading antibacterial drugs

[0066] Disperse antibacterial drugs and photothermal nanomaterials in deionized water, incubate together in a rotary mixer, and then remove unadsorbed antibacterial drugs by centrifugation and deionized water washing methods to obtain photothermal nanomaterials loaded with antimicrobial drugs ;

[0067] Step 3. Synthesis of multifunctional nanocomposite dressing

[0068] An acetic acid solution of alkylated chitosan and an aqueous solution of aldehyde functionalized polyethylene glycol were prepared respectively;

[0069] The photothermal nanomaterials loaded with antibacterial drugs were mixed with the acetic acid solution of alkylated chitosan, and the aqueous solution of aldehyde-functionalized polyethylene glycol was added, and mi...

Embodiment 1

[0071] Synthesis and performance characterization of embodiment 1 hydrogel dressing

[0072] (1) Synthesis of hydrogel dressing

[0073] The synthetic method of the PEG of step 1, aldehyde group functionalization

[0074] 4-Formylbenzoic acid (0.5 g), PEG 2000 (1.6 g) and 4-dimethylaminopyridine (0.025 g) were dissolved in 50 mL of tetrahydrofuran, dicyclohexylcarbodiimide (0.84 g) was added, and The reaction was stirred overnight at room temperature. The resulting white solid was filtered off. The filtrate was purified three times by dissolving with appropriate amount of tetrahydrofuran and then adding diethyl ether to precipitate. For its H NMR spectrum, see Figure 8 .

[0075] 1 H NMR (500MHz, CDCl 3 ,δ):10.11(s,2H),8.22(d,J=8.3Hz,4H),7.95(d,J=8.3Hz,4H),4.53-4.50(m,4H),3.86-3.84(m, 4H),3.70-3.60(m,172-176H).

[0076] The synthetic method of the chitosan (FCS) of step 2, alkylation

[0077] 1g of chitosan was first dissolved in 50mL of 0.2M acetic acid solution, a...

Embodiment 2

[0090] Synthesis and characterization of embodiment 2 multifunctional nanocomposite dressing

[0091] (1) Synthesis of multifunctional nanocomposite dressings

[0092] Step 1. Synthesize WS 2 Nanosheets

[0093] Add 15 mL of oleylamine to a 100 mL flask, heat to 65 °C, and degas under vacuum for 1 hour. Then continue to heat up to 320°C in an argon-protected environment, and add 500 μL of hexamethyldisilazane. At the same time prepare the precursor solution: 50mg of WCl 6 Completely dissolve in 300 μL oleic acid, add 5 mL of oleylamine, at this time the color of the solution changes from dark brown to yellow. Next, quickly add 240 μL CS 2 , the color of the solution turned orange. Inject the precursor solution into the heated hot oleylamine solution with a syringe pump at a rate of 0.15 mL / min. After the reaction solution was cooled to room temperature, 10 mL of n-hexane and 10 mL of isopropanol were added to the reaction solution to precipitate WS 2 Nanosheets. The nan...

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Abstract

The invention relates to a hydrogel dressing, a preparation method thereof, a multifunctional nano-composite dressing, and a preparation method and application of the multifunctional nano-composite dressing, and relates to the technical field of medical dressings. The technical problems that an existing gel dressing is usually single in function, difficultly covers a whole wound repairing period,is poor in antibacterial performance and difficultly achieves satisfactory effect are solved. Modified chitosan and functionalized polyethylene glycol are utilized to construct the multifunctional hydrogel dressing, and the dressing has good biocompatibility, anti-inflammatory property, proper skin adhesion and certain hemostasis performance and can meet various complex clinical requirements. Photo-thermal nano material and antibacterial drugs are carried in a net structure of the hydrogel dressing, so that the multifunctional nano-composite dressing is provided, and the antibacterial propertyof the dressing is improved. The multifunctional nano-composite dressing can play an obvious promoting role in a treatment period and a prognosis period of a healing process of a bacterially infectedwound, and deficiencies of current commercial dressings are overcome.

Description

technical field [0001] The invention relates to the technical field of medical dressings, in particular to a hydrogel dressing and a preparation method thereof, a multifunctional nanocomposite dressing, a preparation method and applications thereof. Background technique [0002] Skin is the body's natural physiological barrier against the external environment, which can effectively prevent tissue dehydration and microbial invasion. But at the same time, the characteristics of the skin also make it vulnerable to varying degrees of damage. Surgical trauma and wound bacterial infection have become common medical problems. Generally, the repair of skin wounds goes through four typical stages: the hemostatic stage, the inflammatory stage, the cell proliferation stage, and the tissue remodeling stage. [0003] The traditional method of treating wounds with bacterial infections is to use antibiotics. However, long-term use of antibiotics may induce bacterial drug resistance, whic...

Claims

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Application Information

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IPC IPC(8): A61L26/00
CPCA61L26/0019A61L26/0023A61L26/0061A61L26/0066A61L26/008A61L2300/404A61L2400/04C08L5/08C08L71/02
Inventor 于聪杨娜祝明徐国超刘宁
Owner CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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