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Falecalcitriol tablet and preparation method thereof

The technology of fluorocalcitriol tablets and fluorocalcitriol is applied in the field of medicine, can solve the problems of low bioavailability, slow down the absorption rate, reduce the number of times of taking medicines, etc., and achieves simple preparation process, reduced dosage and product quality. stable effect

Inactive Publication Date: 2020-10-30
CP PHARMA QINGDAO CO LTD
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  • Abstract
  • Description
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AI Technical Summary

Problems solved by technology

[0006] In order to solve the disadvantages of inconvenient taking and low bioavailability of the existing fluorocalciotriol preparations, the present invention invented fluorocalciotriol sustained-release tablets, which can reduce the number of times of taking medicine, slow down the absorption rate, prolong the biological half-life, and control the blood drug concentration at Within the effective blood concentration range, thereby reducing side effects and improving patient compliance

Method used

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  • Falecalcitriol tablet and preparation method thereof
  • Falecalcitriol tablet and preparation method thereof
  • Falecalcitriol tablet and preparation method thereof

Examples

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Effect test

Embodiment 1-6

[0020] The preparation of embodiment 1-6 fluocautotriol sheet:

[0021] According to the raw and auxiliary materials in the following table, according to the above-mentioned preparation method, the citriol tablets of 6 examples were prepared.

[0022] Table 1 Examples 1-6

[0023]

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Abstract

The invention provides a preparation method of a falecalcitriol tablet, and belongs to the technical field of medicines. The falecalcitriol tablet disclosed by the invention is prepared from falecalcitriol, a sustained-release material, a filling agent, a lubricating agent and a 95% ethanol solution. The main component of the pharmaceutical composition is falecalcitriol which belongs to vitamin D3analogues, can regulate calcium metabolism and resist rickets, and is used for treating parathyroid hypofunction. The method provides a sustained-release preparation which is safe, effective, stablein quality, low in cost, low in administration frequency, high in patient compliance and capable of slowly releasing drugs.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a preparation method of fluocautotriol tablets. The invention provides a slow-release preparation that is safe, effective, stable in quality, low in cost, less in administration frequency, and enhanced in patient compliance. . Background technique [0002] Calcitriol is an analogue of vitamin D3 and a derivative of the active form of the small intestine. It plays a role by binding to receptors distributed in target tissues. This product can regulate calcium metabolism and resist rickets. It is used for the treatment of parathyroid function Hypoplasia. Existing calcitriol preparations are mainly tablets, and calcitriol tablets were jointly developed and marketed by Sumitomo and Taisho Pharmaceutical in Japan at the earliest in April 2001; they are not listed in other countries. [0003] The parathyroid glands are endocrine glands mostly located behind the lateral lobe of the thyr...

Claims

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Application Information

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IPC IPC(8): A61K9/22A61K47/38A61K47/36A61K31/593A61P3/14A61P19/08A61P5/18
CPCA61K9/205A61K9/2054A61K31/593A61P3/14A61P5/18A61P19/08
Inventor 孙桂玉陈阳生臧云龙刘晓霞王明刚王清亭张怀征汪泓刘昭嵘
Owner CP PHARMA QINGDAO CO LTD
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