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Curcumin nano-particles and preparation method thereof

A technology of nanoparticles and curcumin, which is applied in the preparation method of peptides, chemical instruments and methods, pharmaceutical formulations, etc., can solve the problems of hindering wide application, poor redispersibility of naked protein nanoparticles, instability and water solubility, etc. , to achieve the effects of narrow PDI value, improved UV radiation stability and high encapsulation efficiency

Active Publication Date: 2020-11-06
ZHEJIANG GONGSHANG UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to its susceptibility to environmental influences (e.g., pH, ionic strength, and pepsin), it suffers from instability and low water solubility
In addition, the redispersibility of naked protein nanoparticles becomes poor after spray / freeze drying, which further hinders their widespread application.

Method used

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  • Curcumin nano-particles and preparation method thereof
  • Curcumin nano-particles and preparation method thereof
  • Curcumin nano-particles and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] A preparation method of curcumin nanoparticles, comprising the following steps:

[0044] (1) At room temperature (21° C.), add two grams of BSG protein extract and curcumin to 100 mL of water and mix; the concentration of curcumin in this example is 0.5 mg / mL;

[0045] (2) Use 3M NaOH to adjust the pH value of the mixed solution obtained in step (1) to 12.0, then carry out magnetic stirring at a speed of 600rpm, so that each component is evenly dispersed;

[0046] (3) After incubating for 30 minutes, add 10 ml of the dispersion obtained in step (2) dropwise to 40 ml of 0.2% (w / v) lecithin solution, and use an Ultra Turrax T25 homogenizer to homogenize at a speed of 8000 rpm 3 minutes; the preparation method of the 0.2% (w / v) lecithin solution is as follows: 0.2 g lecithin is dissolved in 100 mL of water.

[0047] (4) The dispersion obtained in step (3) was neutralized to pH 7.0, and centrifuged at 2000g for 10 minutes, and the lower layer was discarded (ie, aggregates ...

Embodiment 2

[0056] In the present embodiment, the concentration of curcumin is 1mg / mL;

[0057] Other implementations in this embodiment are the same as in Embodiment 1.

Embodiment 3

[0059] In the present embodiment, the concentration of curcumin is 2mg / mL;

[0060] Other implementations in this embodiment are the same as in Embodiment 1.

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Abstract

The invention discloses curcumin nano-particles and a preparation method thereof. The curcumin nano-particles compounded by BSG protein extract and lecithin are prepared with a base and / or alcohol extracted BSG protein extract as carrier of curcumin. The prepared curcumin nano-particles are spherical and uniform, and have good dispersibility, narrow PDI value and high encapsulating efficiency. Thecurcumin is wrapped in a hydraophobic nuclear of the BSG protein extract, and solubility, heat stability and ultraviolet radiation stability of the wrapped curcumin are remarkably improved; and besides, the wrapped curcumin has higher DPPH free radical scavenging activity than free curcumin.

Description

technical field [0001] The invention specifically relates to a curcumin nanoparticle and a preparation method thereof. Background technique [0002] In recent decades, the use of colloid drug delivery systems to encapsulate and protect biologically active substances such as phytochemicals, essential oils, and peptides to improve their physical and chemical properties or control their release in the human gastrointestinal tract (GI) has received increasing attention. focus on. Naturally occurring food biomacromolecules, such as proteins, are considered an ideal candidate due to their biocompatibility / biodegradability and lower toxicity compared to other synthetic polymers or surfactants. Encapsulating / wrapping material. [0003] Curcumin is a chemical component extracted from the rhizomes of some plants in Zingiberaceae and Araceae. Among them, turmeric contains about 3% to 6%, which is a rare pigment with diketones in the plant kingdom, which is diketones compound. Curcu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/51A61K47/42A61K47/24A61K31/12A61P39/06C07K1/14C07K1/30
CPCA61K9/5169A61K9/5123A61K9/5192A61K31/12A61P39/06C07K1/145C07K1/30
Inventor 章悦王磊
Owner ZHEJIANG GONGSHANG UNIVERSITY
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