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Antibacterial nanoparticles based on berberine derivatives and rhamnolipids

A technology of rhamnolipid and berberine, which can be used in antibacterial drugs, resistance to vector-borne diseases, and medical preparations with inactive ingredients, etc.

Active Publication Date: 2022-05-27
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Based on this protective barrier, it is difficult for antibiotics to reach an effective bactericidal concentration at the site of H. pylori infection, resulting in a decrease in the clearance rate of drugs against H. pylori

Method used

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  • Antibacterial nanoparticles based on berberine derivatives and rhamnolipids
  • Antibacterial nanoparticles based on berberine derivatives and rhamnolipids
  • Antibacterial nanoparticles based on berberine derivatives and rhamnolipids

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Experimental program
Comparison scheme
Effect test

Embodiment

[0046] 1. Preparation and characterization of self-assembled nanoparticles

[0047] method

[0048] Preparation of Berberine Derivatives / Rhamnolipid Self-Assembled Nanoparticles (BD / RHL NPs): Weigh the dodecylberberine derivatives (C10-BD) and dodecylberberine derivatives ( C12-BD), hexadecylberberine derivatives (C16-BD) and octadecylberberine derivatives (C18-BD), were dissolved in DMSO by ultrasonic wave, and the concentration was 5 mg / mL. An aqueous solution of rhamnolipid (RHL) was prepared at a concentration of 2 mg / mL. Four solutions of berberine derivatives (BD) were taken and added dropwise to the RHL solution with stirring, and the stirring was continued for 2 min after the BD solution was dripped to form BD / RHL NPs. The BD / RHL NPs were dialyzed in a 3500kD dialysis bag for 6h to remove the organic solvent. Observe the appearance of the solution, and measure its particle size and potential.

[0049] Screening of the mass ratio of BD and RHL: Precisely draw a cert...

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Abstract

The invention provides an antibacterial nanoparticle, which is formed by self-assembly of berberine derivatives and rhamnolipids. The invention provides the application of the antibacterial nanoparticles in the preparation of antibacterial preparations, wherein the bacteria are biofilm-producing bacteria, including microaerophilic bacteria (such as H. pylori ), aerobic bacteria (such as P. aeruginosa ) and facultative anaerobes (such as E. coli and S. aureus ), anaerobic bacteria (such as S.mutans ), which cover Gram-negative and Gram-positive bacteria. In one embodiment, the biofilm-producing bacteria are H. pylori .

Description

technical field [0001] The invention relates to a nano-drug delivery system, in particular to antibacterial nanoparticles for removing biofilms, in particular to a nano-formulation for killing or removing bacteria colonized in or under the mucus layer of epithelial cells. Background technique [0002] Helicobacter pylori (H. pylori) is a polyflagellated, helical rod-shaped microaerophilic Gram-negative bacterium that can cause gastritis, gastric ulcer, gastric cancer and other malignant diseases. Early triple therapy with amoxicillin, clarithromycin, and proton pump inhibitors was used to treat H. pylori, which has been resistant to antibiotics, including clarithromycin and metronidazole, over the past few years. increased. To improve the clearance rate of H. pylori, quadruple therapy derived from triple therapy has become the first-line treatment for H. pylori infection. Quadruple therapy adds bismuth to triple therapy to protect the damaged gastric mucosa. Although the ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/51A61K47/26A61K31/4375A61P31/04
CPCA61K9/5123A61K31/4375A61P31/04Y02A50/30
Inventor 胡海燕申元娜邹祎晴李彭宇陈小楠饶义琴
Owner SUN YAT SEN UNIV
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