Macroporous hydrogel as well as preparation method and application thereof

A hydrogel and gelatin technology, applied in the field of macroporous hydrogel and its preparation, can solve the problems of difficult to prepare hydrogel with super large pore size, unfavorable material biocompatibility, lack of uniform pore structure, etc., and achieve good application Prospects, excellent biocompatibility and degradability, good biocompatibility
CN111978588AActive Publication Date: 2020-11-24GUANGDONG PROV MEDICAL INSTR INST
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
GUANGDONG PROV MEDICAL INSTR INST
Publication Date
2020-11-24

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Abstract

The invention provides macroporous hydrogel and a preparation method and application thereof. The preparation method comprises the steps that: water-soluble gelatin microspheres are adopted as a pore-foaming agent, gelatin microsphere interfaces are bonded with one another in a heating mode, a gelatin microsphere template is removed after crosslinking and gelling, and finally the macroporous hydrogel with controllable pore diameter and mutual communication is formed. Adhesion, migration and proliferation of cells and transportation of oxygen, nutrient substances and the like are facilitated, avascularization promoting gel stent is expected to be further developed, and application of the hydrogel in tissue engineering and regenerative medicine is expanded. Compared with macroporous hydrogel prepared by traditional methods, the macroporous hydrogel prepared by the method has the advantages that the gelation time is short, the gelation can be completed within a few seconds, the pore structure is controllable, uniform and mutually communicated, and the pore diameter range is 30-600 microns.
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Description

technical field

[0001] The invention belongs to the technical field of biomaterials, and in particular relates to a macroporous hydrogel and a preparation method and application thereof. Background technique

[0002] Tissue engineering and regenerative medicine achieve tissue repair or regeneration by constructing tissue engineering scaffolds to simulate extracellular matrix and seed cells to form a complex. In order to better repair different damaged tissues, it is crucial to construct tissue engineering scaffolds with similar physical and chemical properties of extracellular matrix through biomimetic design. Hydrogel has been widely used in the field of tissue engineering and regenerative medicine because of its biomimetic structure highly similar to natural extracellular matrix, good mechanical properties, biocompatibility, and easy preparation. Three-dimensional culture and delivery system.

[0003] However, the loaded cells are usually coated and confined in the submi...

Claims

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