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Application of metabolite detection marker in preparation of multiple myeloma diagnosis tool

A technology for multiple myeloma and a diagnostic tool, which is applied in the field of biomedicine to achieve the effects of simple sample pretreatment, short sample analysis time, and a wide range of substance detection

Active Publication Date: 2020-11-24
BEIJING CHAOYANG HOSPITAL CAPITAL MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the limitations of detection technology and application, further research is needed to find more multiple myeloma biomarkers and apply them in clinical diagnosis.

Method used

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  • Application of metabolite detection marker in preparation of multiple myeloma diagnosis tool
  • Application of metabolite detection marker in preparation of multiple myeloma diagnosis tool
  • Application of metabolite detection marker in preparation of multiple myeloma diagnosis tool

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Example 1: Screening of differential metabolites between multiple myeloma patients and healthy individuals

[0039] 1. Objects and methods

[0040] 1. Sample source

[0041] After signing informed consent with the participants and approval by the Ethics Committee of Beijing Chaoyang Hospital Affiliated to Capital Medical University, peripheral blood samples from 30 HC (healthy controls) and 100 MM patients were collected. All participants were from Beijing Chaoyang Hospital Affiliated to Capital Medical University. All MM patients were diagnosed according to the IMWG standard. All MM patients were within 4 courses of chemotherapy. After investigation, the patients did not have significant differences due to different courses of treatment. metabolic changes. The age and sex of HC were matched with those of MM patients to exclude metabolic differences caused by sex and age. The time of blood collection was in the morning on an empty stomach. All samples were stored at...

Embodiment 2

[0059] Clinical analysis of specific cases:

[0060] (1) Sample collection:

[0061] Peripheral blood samples were collected from 6 HC (healthy controls) and 24 suspected MM patients. All participants were from Beijing Chaoyang Hospital Affiliated to Capital Medical University. The age and sex of HC were matched with suspected MM patients to exclude metabolic differences caused by sex and age. The time of blood collection was in the morning on an empty stomach. Collect fasting plasma samples from the subjects and store them in a -80°C refrigerator for later use. The diagnosis of all patients with suspected MM was confirmed using the following clinical diagnosis basis.

[0062] 1. Symptoms and signs

[0063] The most common signs and symptoms in patients with MM are related to anemia, renal insufficiency, infection, or bone destruction. As shown in Table 2, the common ones are:

[0064] (1) Skeletal symptoms: bone pain, local mass, pathological fracture, and paraplegia m...

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Abstract

The invention discloses application of a plasma metabolite detection marker in preparation of a multiple myeloma diagnosis tool. The plasma metabolite marker comprises one or more of L-arginine, N-acetylneuraminic acid, DL-pyroglutamic acid, L-malic acid, L-lactic acid and linoleoyl carnitine. A non-invasive and relatively non-invasive detection mode is adopted, the blank of application of an existing multiple myeloma clinical detection technology is filled up, and a foundation is laid for individualized accurate treatment of multiple myeloma patients.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to biotechnology, disease diagnosis, safety and effectiveness evaluation of new drugs or new treatments in patients with multiple myeloma. More specifically, the present invention relates to the application of detecting metabolite markers in the preparation of multiple myeloma diagnostic tools. Background technique [0002] Multiple myeloma (MM) is a hematological malignancy caused by abnormal proliferation of plasma cells in the bone marrow. It is the second most common hematological malignancy in clinical practice. disease, renal insufficiency, recurrent infection, and osteolytic injury. Multiple myeloma accounts for about 10% of hematological tumors and 0.8% of all malignant tumors. The age of onset is about 60 years old, the median survival period is 3 to 5 years, and the male to female ratio is 1.6:1. The incidence rate in my country is about 1 / 100,000, which is lower than 4 / 100,00...

Claims

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Application Information

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IPC IPC(8): G01N30/02G01N30/06G01N33/68
CPCG01N30/02G01N30/06G01N33/68G01N2800/7028
Inventor 刘丽宏胡婷朱莹赵志霞郭立方许本善
Owner BEIJING CHAOYANG HOSPITAL CAPITAL MEDICAL UNIV
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