Method for administrating doxycycline hydrochloride and florfenicol to respiratory tract pathogenic bacteria based on PK/PD model

Abstract

The invention discloses a method for administrating doxycycline hydrochloride and florfenicol to respiratory tract pathogenic bacteria based on a PK / PD model. The method comprises the following steps:determining the optimal combined medication proportion of doxycycline hydrochloride and florfenicol on actinobacillus pleuropneumoniae and haemophilus parasuis respectively; under the optimal combined medication proportion of doxycycline hydrochloride and florfenicol, detecting the in-vitro drug sensitivity of doxycycline hydrochloride and florfenicol to actinobacillus pleuropneumoniae and haemophilus parasuis independently and jointly, and counting MIC distribution; and formulating a dosing scheme of the doxycycline hydrochloride and florfenicol injection on actinobacillus pleuropneumoniae and haemophilus parasuis under three dosing purposes of preventing, treating and eradicating diseases, and finally taking the dosing scheme of the component with a relatively small treatment dose in combined medication components as a final dosing scheme.

Description

Technical field [0001] The present invention relates to the technical field of PK-PD model, in particular to a method for administering doxycycline hydrochloride and florfenicol to respiratory pathogenic bacteria based on the PK / PD model. Background technique [0002] Both Actinobacillus pleuropneumoniae and Haemophilus parasuis are highly pathogenic to pigs and pose the greatest threat to the development of the breeding industry. They mainly cause infectious pleuropneumonia, pleurisy and arthritis-based respiratory diseases. [0003] With the increasing resistance of Actinobacillus pleuropneumoniae and Haemophilus parasuis to antibiotics, more and more drugs can no longer be used in the clinical treatment of Actinobacillus pleuropneumoniae and Haemophilus parasuis. Fluorobenzene Nicol and doxycycline are widely used in the treatment of swine respiratory diseases in veterinary clinics due to their broad antibacterial spectrum and strong activity. However, due to unreasonable select...

AI Technical Summary

Problems solved by technology

[0003] With the increasing resistance of Actinobacillus pleuropneumoniae and Haemophilus parasuis to antibiotics, more and more drugs can no longer be used in the clinical treatment of Actinobacillus pleuropneumoniae and Haemophilus parasuis. Nicholas and doxycycline are widely used in the treatment of porcine respiratory diseases in veterinary clinics due to their broad antibacterial spectrum and strong activity. However, due to the unreasonable selection and abuse of drugs, drug resistance has largely emerged , and the clinical etiology is complex, often manifested as mixed infection of multiple diseases, it is difficult to achieve a good therapeutic effect with a single drug

Images