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Amoxicillin and clavulanate potassium preparation and preparation method thereof

A technology of amoxicillin-clavulanate potassium and clavulanate potassium, which is applied in the direction of pharmaceutical formulas, medical preparations of non-active ingredients, inorganic non-active ingredients, etc., and can solve the difficulties and limitations of amoxicillin and clavulanate potassium Problems such as development and application of oral preparations, poor stability, etc., to achieve the effect of improving bioavailability, increasing residence time, and good stability

Active Publication Date: 2020-12-01
RINGPU TIANJIN BIOLOGICAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, both amoxicillin and potassium clavulanate have certain difficulties in veterinary clinical use.
Potassium clavulanate has strong hygroscopicity, poor stability, high temperature and high humidity will lead to its degradation
Amoxicillin has a narrow absorption window in animals, especially pigs, and is mainly absorbed in the upper gastrointestinal tract, which limits the development and application of oral preparations

Method used

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  • Amoxicillin and clavulanate potassium preparation and preparation method thereof
  • Amoxicillin and clavulanate potassium preparation and preparation method thereof
  • Amoxicillin and clavulanate potassium preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] A kind of amoxicillin clavulanate potassium preparation, described preparation is prepared by following method:

[0025] (1) Thoroughly mix 6.25g potassium clavulanate mixture with 15g tributyrin for 30min to obtain mixture A; uniformly mix mixture A with 11.5g amoxicillin, 3g citric acid, 3g sodium bicarbonate and 60g lactose for 30min , to obtain mixture B.

[0026] (2) Wet 2.15 g of konjac glucomannan superporous composite hydrogel with 13 ml of absolute ethanol to prepare an adhesive solution, and obtain solution C.

[0027] (3) Spray the solution C on the mixture B, and after the soft material is obtained, granulate with a 20-mesh swing granulator.

[0028] (4) Vacuum drying at room temperature for 6 hours to obtain amoxicillin-clavulanate potassium (4:1) granules.

Embodiment 2

[0030] A kind of amoxicillin clavulanate potassium preparation, described preparation is prepared by following method:

[0031] (1) Fully mix 6.25g of potassium clavulanate mixture with 25g tributyrin for 30min to obtain mixture A; uniformly mix mixture A with 11.5g of amoxicillin, 10g of citric acid, 10g of sodium bicarbonate, and 36g of lactose 30min, the mixture B was obtained.

[0032] (2) Wet 5 g of konjac glucomannan superporous composite hydrogel with 30 ml of absolute ethanol to prepare an adhesive solution, and obtain solution C.

[0033] (3) Spray the solution C on the mixture B, and after the soft material is obtained, granulate with a 20-mesh swing granulator.

[0034] (4) Vacuum drying at room temperature for 12 hours to obtain amoxicillin clavulanate potassium (4:1) granules.

Embodiment 3

[0036] A kind of amoxicillin clavulanate potassium preparation, described preparation is prepared by following method:

[0037] (1) Mix 6.25g of potassium clavulanate mixture with 20g of stearyl alcohol for 30min to obtain mixture A; mix mixture A with 11.5g of amoxicillin, 5g of citric acid, 5g of sodium bicarbonate, and 49g of lactose for 30min, Mixture B is obtained.

[0038] (2) Wet 2.5 g of polyvinylpyrrolidone with 15 ml of absolute ethanol to prepare an adhesive solution and obtain solution C.

[0039] (3) Spray the solution C on the mixture B, and after the soft material is obtained, granulate with a 20-mesh swing granulator.

[0040] (4) Vacuum drying at room temperature for 8 hours to obtain amoxicillin clavulanate potassium (4:1) granules.

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Abstract

The invention aims to provide an amoxicillin and clavulanate potassium preparation and a preparation method thereof. The preparation is prepared by mixing amoxicillin, clavulanate potassium and certain auxiliary materials. The amoxicillin and clavulanate potassium preparation is good in stability, effectively solves the problem that the clavulanate potassium is not resistant to storage, improves the bioavailability of amoxicillin in a pig body, effectively reduces the dosage of antibiotics, and overcomes the defects in the prior art.

Description

technical field [0001] The invention belongs to the technical field of veterinary chemical preparations, and in particular relates to a potassium amoxicillin-clavulanate preparation and a preparation method thereof. Background technique [0002] Amoxicillin belongs to the β-lactam antibiotics and is one of the most widely used antibiotics. However, with its wide application in veterinary clinics, the problem of bacterial drug resistance is also becoming more and more serious. The β-lactamase produced by bacteria destroys the β-lactam ring and inactivates antibiotics, which is the most common and main mechanism of drug resistance. [0003] Clavulanic acid is generally an irreversible inhibitor of β-lactamase, which can permanently inactivate the enzyme by competitively binding to β-lactamase after the formation of an acylase intermediate, thereby protecting the original activity of the antibiotic , so that the antibiotics that cooperate with it have a wider antibacterial sp...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61K47/12A61K47/02A61K47/26A61K47/14A61K47/10A61K47/32A61P31/04
CPCA61K9/0065A61K9/1623A61K9/1617A61K9/1611A61K9/1652A61K9/1635A61K9/1641A61P31/04
Inventor 李雪娇刘爱玲聂丽娜李守军李亚玲栗栖凤曹春芳吴燕子
Owner RINGPU TIANJIN BIOLOGICAL PHARMA
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