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Biomass-based hydrogel antibacterial wound dressing

A wound dressing and hydrogel technology, which is applied in medical science, bandages, etc., can solve the problems of mechanical properties, wound protection, wound exudate absorption and water retention, and antibacterial adhesion that cannot meet the requirements of single use. Good osmotic fluid absorption capacity, realization of performance, effect of improving antibacterial properties

Active Publication Date: 2020-12-01
HUNAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The present invention is dedicated to overcoming the problems that the mechanical properties of chitosan-based wound dressings, the protection of wounds, the absorption of wound exudate, water retention, antibacterial properties and adhesion cannot meet the requirements of separate use, and provides a Two-layer biomass-based hydrogel antimicrobial wound dressing for single use

Method used

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  • Biomass-based hydrogel antibacterial wound dressing
  • Biomass-based hydrogel antibacterial wound dressing
  • Biomass-based hydrogel antibacterial wound dressing

Examples

Experimental program
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Effect test

Embodiment 1

[0039] A biomass-based hydrogel antibacterial wound dressing is composed of double-layer gel film layers, including a surface layer of polyvinyl alcohol-polyacrylamide gel film layer and a bottom layer of chitosan-based antibacterial gel film layer.

[0040] (1) Preparation of surface polyvinyl alcohol-polyacrylamide gel film layer:

[0041] Use glycerin / water as a mixed solvent, dissolve polyvinyl alcohol at 90°C to obtain a certain concentration of polyvinyl alcohol solution I for use, and mix a certain proportion of monomer acrylamide, cross-linking agent N, N'-methylene Add bisacrylamide and initiator ammonium persulfate into deionized water at room temperature and stir until dissolved to form a uniform solution II. Then add a certain amount of polyvinyl alcohol solution I to solution II. After stirring evenly, add initiator HCl to the solution to promote Agent tetramethylethylenediamine, cross-linking agent glutaraldehyde, stirred at high speed within 2 minutes, then pour...

Embodiment 2

[0056] A biomass-based hydrogel antibacterial wound dressing is composed of double-layer gel film layers, including a surface layer of polyvinyl alcohol-polyacrylamide gel film layer and a bottom layer of chitosan-based antibacterial gel film layer.

[0057] Further, its preparation process includes the following steps:

[0058] (1) Preparation of surface polyvinyl alcohol-polyacrylamide gel film layer:

[0059] Use glycerin / water as a mixed solvent, dissolve polyvinyl alcohol at 92°C to obtain a certain concentration of polyvinyl alcohol solution I for use, and mix a certain proportion of monomer acrylamide, cross-linking agent N, N'-methylene Add bisacrylamide and initiator ammonium persulfate into deionized water at room temperature and stir until dissolved to form a uniform solution II. Then add a certain amount of polyvinyl alcohol solution I to solution II. After stirring evenly, add initiator HCl to the solution to promote Agent tetramethylethylenediamine, cross-linkin...

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Abstract

The invention relates to a biomass-based hydrogel antibacterial wound dressing. The hydrogel antibacterial wound dressing is composed of double gel film layers including a surface protection gel filmlayer and a bottom chitosan-based antibacterial film layer, and the two film layers are crosslinked into a whole through a Schiff base reaction between aldehyde-terminated four-arm polyethylene glycolin the bottom layer and polyacrylamide in the surface layer. The composite film has good biocompatibility, antibacterial property, skin adhesion, absorption swelling property, water-retaining property and water vapor permeability, also has excellent mechanical properties, and can be independently used as an antibacterial wound dressing.

Description

technical field [0001] The invention relates to a biomass-based hydrogel antibacterial wound dressing, in particular to a dressing that can be used alone and has good biocompatibility, antibacterial properties, adhesion, wound exudate absorption, water retention and mechanical properties wound dressing. Background technique [0002] The open wound surface of the human body is often prone to infection. How to effectively reduce the probability of wound infection and promote wound recovery and tissue refunctionalization is a hotspot and difficulty to be solved in the medical field. Traditional dressings such as gauze and bandages are composed of dry fabrics. The extent of exudate is limited and easily damages newly formed tissue during removal, causing secondary injury. Hydrogels are a good form of choice for wound dressings due to their swelling, water-retaining, and easy-to-remove properties. Chitosan itself has good antibacterial and cell compatibility, and is often use...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00C08F261/04C08F220/56C08F222/38
CPCA61L26/008A61L26/0061A61L26/0014C08F261/04C08L29/04C08L33/26C08F220/56C08F222/385
Inventor 陈一卢嘉威刘文勇
Owner HUNAN UNIV OF TECH
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