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Implant for preventing bone cement leakage, preparation method and application, complete set of products for preventing bone cement leakage and using method

An implant and bone cement technology, applied in the field of medical devices, can solve the problems of poor dispersion of bone cement, gaps between bone cement and bone, and outflow of bone cement, and achieve good biocompatibility and biosafety. Flow, small pore size effect

Pending Publication Date: 2020-12-11
BEIJING BONSCI TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] (1) The existing capsular bag filling device only acts as a physical barrier to the filling of bone cement, and most of them use woven grids with large hole diameters, and some bone cement will still flow out of the grids;
[0009] (2) Injection of bone cement in the bag filling device is likely to cause poor dispersion of bone cement;
[0010] (3) Some devices will be withdrawn or degradable after the bone cement is cured, which may easily cause a gap between the bone cement and the bone, resulting in loosening

Method used

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  • Implant for preventing bone cement leakage, preparation method and application, complete set of products for preventing bone cement leakage and using method
  • Implant for preventing bone cement leakage, preparation method and application, complete set of products for preventing bone cement leakage and using method
  • Implant for preventing bone cement leakage, preparation method and application, complete set of products for preventing bone cement leakage and using method

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preparation example Construction

[0065] According to a second aspect of the present invention, a method for preparing an implant for preventing bone cement leakage is provided, comprising the following steps:

[0066] The unmodified or modified PMMA polymer solution is electrospun to form fibers, which are received by a receiving device and dried to obtain a film-shaped implant, then immersed in a developer solution and dried to obtain a film-shaped implant with developability. implants; or,

[0067] The unmodified or modified PMMA polymer solution is mixed with a developer for electrospinning to form fibers, which are received by a receiving device and dried to obtain a film-like implant with developability.

[0068] "Unmodified or modified PMMA polymer solution" refers to a solution of unmodified PMMA polymer, or, a modified PMMA polymer solution.

[0069] "Unmodified or modified PMMA polymer solution and developer" means "unmodified PMMA polymer solution and developer, or, modified PMMA polymer solution a...

Embodiment 1

[0098] Take by weighing the PMMA powder of 5g, slowly add the mixed solvent (DMF:toluene=1:2) of the DMF of 57.5g and toluene therein, preparation concentration is the solution of 8wt%, it is carried out heating magnetic stirring 24h, until polymer is completely When the dissolved and obtained solution is very uniform, transfer it to a 10ml syringe, select a 24G spinning needle to connect the syringe, place it on the electrospinning device and fix it, and turn on the power supply connection voltage, adjust the spinning voltage to 10kV, and spin The distance is 20cm, the spinning speed is 0.8ml / h, and the spinning time is 2.5h. The nanofibers obtained under the conditions are relatively uniform in diameter and good in shape, as shown in figure 1 As shown, the fiber diameter is about 590-680nm, the nanofiber membrane thickness is about 108μm, the pore diameter is about 1.48μm, and the specific surface area is 33m 2 / g. Subsequently, the obtained nanofiber patch was immersed in ...

Embodiment 2

[0100] Take by weighing the PMMA powder of 5g, in the mixed solvent (DMF:toluene=1:2) of the DMF and toluene of slowly adding 36.7g wherein, preparation concentration is the solution of 12wt%, it is carried out heating magnetic stirring 24h, treat polymer When the solution is completely dissolved and the obtained solution is very uniform, transfer it to a 10ml syringe, select a 24G spinning needle to connect the syringe, place it on the electrospinning device and fix it, and turn on the power supply connection voltage, adjust the spinning voltage to 10kV, and spin The filament distance is 20cm, the spinning speed is 0.8ml / h, and the spinning time is 2.5h. Under these conditions, the fiber diameter obtained is relatively uniform and the shape is good. The fiber diameter is 750-900nm, and the thickness of the nanofiber film is 127μm About, the pore diameter is about 2.52μm, the specific surface area is 28m 2 / g, have the same good performance and use effect as Example 1 after so...

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Abstract

The invention provides an implant for preventing bone cement leakage, a preparation method and application, a complete set of products for preventing the bone cement leakage and a using method, and relates to the technical field of medical instruments. The implant is a film-like implant prepared mainly by forming fibers with unmodified or modified polymethyl methacrylate (PMMA) polymer through electrostatic spinning, and receiving the fibers by a receiving device; the implant has a developing property; the thickness of the implant is 50-150 [mu]m; the diameter of the fibers is 500-900nm; the pore diameter of the implant is 0.7-4 [mu]m; and the specific surface area of the implant is 25-40m<2> / g. According to the invention, a nano-fiber patch is prepared by taking PMMA as a raw material through electrostatic spinning, and the nano-fiber patch can effectively prevent bone cement leakage, and meanwhile, does not limit flowing of bone cement.

Description

technical field [0001] The invention relates to the technical field of medical devices, in particular to an implant for preventing bone cement leakage, a preparation method and application, a complete set of products for preventing bone cement leakage, and a use method. Background technique [0002] Osteoporosis is a systemic disease characterized by loss of bone mass and susceptibility to fractures. With the increase of the aging population base, the incidence of osteoporotic fractures gradually increases, and the vertebral body is the most prone to fractures in osteoporosis. [0003] Aiming at the above-mentioned diseases, methods widely used clinically to treat osteoporotic vertebral compression fractures include percutaneous vertebroplasty (PVP) and percutaneous kyphoplasty (PKP). This method is widely used because of its small trauma, good analgesic effect, good safety, and easy operation. At present, polymethyl methacrylate (PMMA) bone cement is the earliest and most...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/04A61L31/14A61L31/18A61B17/88D04H1/4282D04H1/728
CPCA61B17/8805A61L31/048A61L31/14A61L31/146A61L31/18D04H1/4282D04H1/728C08L33/12
Inventor 聂洪涛张凯王璇汤建华
Owner BEIJING BONSCI TECH CO LTD
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