Compound plant extract preparation for preventing and treating porcine viral diseases and application thereof

A technology of plant extracts and preparations, applied in the direction of diseases, antiviral agents, antiviral agents, etc., can solve the problems of unstable quality, reduced growth performance, low bioavailability, etc., to improve economics and feasibility, improve Virus infection threshold, effect of simple extraction method

Active Publication Date: 2020-12-25
HUNAN DANWEI BILOGICALTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Studies in recent years have shown that some compound plant ingredients (including traditional Chinese medicine) have various effects such as enhancing immunity, anti-oxidation, antibacterial, anti-virus, and growth promotion, and have certain effects on the prevention and treatment of viral diseases. Most antiviral preparations on the market choose Radix Isatidis, Folium Isatidis, Forsythia, Honeysuckle and other heat-clearing and detoxifying herbal prescriptions, these preparations can directly act on viruses, and have certain effects in the treatment of viral diseases, but they also have the disadvantage of cold and cold properties, long-term use May cause adverse effects on animal health and reduce growth performance
[0004] At present, compound herbal ingredient preparations are generally divided into three types, which are simple mixing of traditional Chinese medicine, extraction of pure active ingredients of traditional Chinese medicine, or use of plant extracts. Among them, simple mixing of traditional Chinese medicine generally has unstable quality, low bioavailability, poor palatability and use. The problem of excessive dosage. For example, the application number is 201410590846.5, a traditional Chinese medicine for the treatment of blue ear disease. There are deficiencies such as unstable ingredient content, poor palatability, and excessive dosage, making it difficult to guarantee the effect
However, the pure active ingredients of traditional Chinese medicine are expensive and costly, so the development of compound preparations of plant extracts is an important development direction

Method used

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  • Compound plant extract preparation for preventing and treating porcine viral diseases and application thereof
  • Compound plant extract preparation for preventing and treating porcine viral diseases and application thereof
  • Compound plant extract preparation for preventing and treating porcine viral diseases and application thereof

Examples

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preparation example Construction

[0049] In one embodiment, the preparation method of the preparation of the present invention comprises:

[0050] Aqueous enzyme extraction: After pulverizing Poria cocos and Astragalus membranaceus, water and enzymes are added to Poria cocos for hydroenzyme extraction and filtration to obtain filtrate A and filter residue A;

[0051] Alkaline extraction: add filter residue A to dilute alcohol solution, and add crushed astragalus, mix, heat extraction at pH 11-12, and filter to obtain filtrate B and filter residue B;

[0052] Alcohol extraction: After crushing Acanthopanax, add ethanol-water solution, reflux extraction, and filter to obtain filtrate C and filter residue C;

[0053] Water extraction: After crushing the licorice root, adding filter residue B and filter residue C to mix, add water to reflux extraction, and filter to obtain filtrate D and filter residue D, continue to extract filter residue D with water, and filter to obtain filtrate E;

[0054] Drying: Combine fi...

Embodiment 1

[0098] The invention provides a compound herbal preparation, the preparation method of which comprises:

[0099] Aqueous enzyme extraction: After pulverizing Poria cocos into 80 meshes, adding 80wt% ethanol solution to leaching for 6 hours at 5°C, filtering to obtain filtrate F and filter residue F, adding water and β-glucanase to filter residue F, at 60°C, The enzyme concentration is 0.8U / mL, leached for 6h, filtered to obtain filtrate A and filter residue A; the weight ratio of the Poria cocos to 80wt% ethanol solution is 1:5; the weight ratio of the filter residue E to water is 1:3;

[0100] Alkaline extraction: add the filter residue A to 5wt% ethanol solution, add crushed astragalus membranaceus into 110 mesh, mix, heat to 80°C at pH 11.5, extract for 2 hours, and filter to obtain filtrate B1 and filter residue B1, and repeat alkali extraction of filter residue B1, Obtain filtrate B2 and filter residue B2, combine filtrate B1 and filtrate B2 to obtain filtrate B; the weig...

Embodiment 2

[0106] The invention provides a compound herbal preparation, the preparation method of which comprises:

[0107] Aqueous enzyme extraction: crush Poria cocos into 70 meshes, add 90wt% ethanol solution to extract for 7 hours at 5°C, filter to obtain filtrate F and filter residue F, add water and β-glucanase to the filter residue F, at 65°C, The enzyme concentration was 1 U / mL, leached for 7 hours, and filtered to obtain filtrate A and filter residue A; the weight ratio of the poria cocos to 90wt% ethanol solution was 1:8; the weight ratio of the filter residue E to water was 1:4;

[0108] Alkaline extraction: add the filter residue A to 3wt% ethanol solution, and add astragalus crushed into 100 mesh, mix, heat to 90°C at pH 11, extract for 1.5h, filter to obtain filtrate B1 and filter residue B1, and repeat alkali extraction of filter residue B1 , obtain filtrate B2 and filter residue B2, combine filtrate B1 and filtrate B2 to obtain filtrate B; the weight ratio of the total we...

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Abstract

The invention relates to the technical field of veterinary drugs, in particular to a compound plant extract preparation for preventing and treating porcine viral diseases and application thereof. Effective components such as compound plant polysaccharide and saponin are used, and the content of the components is controlled, so that the autoimmunity of animals is regulated, and the virus infectionthreshold value is increased; and plant polysaccharide components are combined with virus binding targets to block virus adhesion. By standardizing key index components and contents, the quality of the compound plant extract product is controllable, and the virus prevention and treatment effect of the preparation is guaranteed. Warm-tonifying plants free of obvious harmful substances are selectedas raw materials, so that long-term group administration can be realized, the extraction method is simple, only simple filtration is required, further purification is not required, and the cost is reduced. The compound plant extract preparation has the auxiliary effects of promoting appetite of pigs and other livestock, resisting oxidation and stress, inducing diuresis, expelling toxin, promotingyield increase and the like, and the application range is widened.

Description

technical field [0001] The invention relates to the technical field of veterinary medicine, more specifically, the invention relates to a compound plant extract preparation for preventing and controlling porcine viral diseases and application thereof. Background technique [0002] Viral diseases have caused great losses to the pig industry, and there is currently no effective control drug. The common ones are PRRS and pseudorabies. In pig production, the control of viral diseases is still a difficult point, especially in recent years, some new viral diseases such as blue ear disease, circovirus disease, African swine fever, etc. have caused huge losses to my country's pig industry . PRRS, also known as Respiratory and Reproductive Impairment Syndrome, is a viral disease that is widely infected in pig herds, causing reproductive and respiratory disorders in sows, thereby seriously affecting production indicators such as birth weight, total weaning rate, and survival rate of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/484A61K36/638A61K36/744A61K36/8945A61K36/734A61K31/7048A61K31/7034A61K31/704A61P31/12A61P31/14A61P31/20A61P31/22A61P1/14A61P39/06A61P39/00A61P7/10A61P39/02A61P15/08
CPCA61K36/076A61K36/481A61K36/254A61K36/484A61K36/638A61K36/42A61K36/744A61K36/284A61K36/8945A61K36/232A61K36/734A61K31/7048A61K31/7034A61K31/704A61P31/12A61P31/14A61P31/20A61P31/22A61P1/14A61P39/06A61P39/00A61P7/10A61P39/02A61P15/08A61K2236/19A61K2236/333A61K2236/331A61K2236/39A61K2236/51A61K2300/00
Inventor 王跃球熊小军梁汉新
Owner HUNAN DANWEI BILOGICALTECH
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