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Hydrogel material and drug delivery system

A delivery system and hydrogel technology, which can be used in drug delivery, ointment delivery, pharmaceutical formulations, etc., can solve problems such as temperature dependence of hydrogel gelation process, and achieve long sustainable drug release time and simple composition. , the effect of easy mass production

Active Publication Date: 2021-01-05
THE HONG KONG POLYTECHNIC UNIV SHENZHEN RES INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The main purpose of the present invention is to provide a hydrogel material, which aims to solve the technical problem that the gelation process of the existing hydrogel depends on temperature changes

Method used

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  • Hydrogel material and drug delivery system
  • Hydrogel material and drug delivery system
  • Hydrogel material and drug delivery system

Examples

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preparation example Construction

[0052] Correspondingly, a preparation method of the above-mentioned hydrogel material, comprising:

[0053] Provide hydroxypropyl methylcellulose, a compound containing a methacrylic acid group, and a reaction solvent, and react the hydroxypropyl methylcellulose and the compound containing a methacrylic acid group in the reaction solvent .

[0054] The preparation method of the above-mentioned hydrogel material provided by the embodiment of the present invention is to modify the hydroxypropyl methylcellulose by reacting the compound containing methacrylic acid group with hydroxypropyl methylcellulose, which is easy to operate. Easy to mass produce.

[0055] Preferably, the compound containing methacrylic acid group includes at least one of glycidyl methacrylate, methacrylic acid and polyglycidyl methacrylate.

[0056] In the embodiment of the present invention, the above-mentioned hydrogel material is preferably glycidyl methacrylate-modified hydroxypropyl methylcellulose. ...

Embodiment 1

[0089] In this example, a hydrogel material for drug delivery was prepared. Hydroxypropyl methylcellulose was modified, and H 2 The viscosity when forming 2wt% aqueous solution in O is that HPMC of 6mPa s is as main raw material, is marked as HPMC-6, and concrete preparation process is as follows:

[0090] 1. Dissolve 2.5g of HPMC-6 in 45mL of anhydrous DMSO under constant stirring at 100°C to prepare HPMC-6 solution;

[0091] 2. Add 0.5 g of 4-dimethylaminopyridine to the HPMC-6 solution, add 0.015 mol glycidyl methacrylate-DMSO solution under an inert nitrogen atmosphere, and react at room temperature for 72 hours.

[0092] 3. After the reaction is completed, the reaction solution is dialyzed with deionized (DI) water for 3 days, and the molecular weight cut-off is 12kDa. Subsequently, the dried product was obtained by freeze-drying, labeled as MH-6, and stored at 4 °C for later use.

Embodiment 2

[0094] The difference between this embodiment and embodiment 1 is: select the H at 20 ℃ 2 The viscosity when forming 2wt% aqueous solution in O is that the HPMC of 15mPa s is as main raw material, is labeled as HPMC-15; The product that obtains is labeled as MH-15;

[0095] The rest are basically the same as those in Embodiment 1, and will not be repeated here.

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Abstract

The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to a hydrogel material for drug delivery and a drug delivery system. The hydrogel material provided by the invention comprises hydroxypropyl methyl cellulose modified by a methacrylic acid group. The hydrogel material is a derivative obtained by modifying hydroxypropyl methyl cellulose with a methacrylic acid group, can drive physical entanglement to form a three-dimensional network structure in a water environment, realizes in-situ gelation, is not influenced by environmental temperature change in the gelation process, and is suitable for delivery of most drugs, so that the drug release duration is long. The drug delivery system provided by the invention comprises hydrogel for loading a drug, and the hydrogel is prepared from the hydrogel material or the hydrogel material prepared by the preparation method. The drug delivery system is high in drug encapsulation efficiency, long in drug sustained release time and suitable for various drugs.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a hydrogel material and a drug delivery system. Background technique [0002] In the process of new drug development, the bioavailability of drugs in vivo is an important factor that researchers must consider. Drugs are absorbed into the blood circulation from the site of administration, and are distributed to various tissues of the body along with the blood. During this period, they will be affected by various factors, such as physiological barriers and blood clearance, etc., resulting in many drugs that cannot be fully absorbed and utilized by the human body. Sustainability, people need to repeat multiple doses. In order to improve the bioavailability of drugs and reduce the number of medications, researchers routinely use appropriate carriers to load drugs to form a drug delivery system, so that drugs can be released slowly in the body through ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08B15/00A61K9/06A61K47/38C08L1/08
CPCC08J3/075C08B15/00A61K9/06A61K9/0024A61K47/38C08J2301/08
Inventor 黎永富黄永德黄敏坚
Owner THE HONG KONG POLYTECHNIC UNIV SHENZHEN RES INST
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