Calcium zinc gluconate oral solution and preparation method thereof

A technology of calcium zinc gluconate and oral solution, which is applied in the fields of pharmaceutical formulation, dispersion liquid delivery, and medical preparations of non-active ingredients, etc., to achieve the effects of preventing tooth decay in children, good process robustness, and preventing precipitation

Inactive Publication Date: 2021-01-08
广州汇元医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The object of the present invention is to provide a kind of calcium-zinc gluconate oral solution and preparation method thereof, do not contain sucrose or aspartame, good stability, simple preparation process, solve existing sweetener selection and existing in the prior art formulation stability issues

Method used

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  • Calcium zinc gluconate oral solution and preparation method thereof
  • Calcium zinc gluconate oral solution and preparation method thereof
  • Calcium zinc gluconate oral solution and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0029] Present embodiment provides a kind of calcium zinc gluconate oral solution, and prescription is composed as follows:

[0030]

[0031] The preparation method of calcium zinc gluconate oral solution comprises the following steps:

[0032] (1) Add purified water of 90% of the prescription amount to the batching tank, turn on the stirring device and open the steam valve, heat to 85°C, maintain at 85°C, add the weighed calcium gluconate, stir for 15 minutes until completely dissolved .

[0033] (2) Maintain the heating temperature at 85°C, add zinc gluconate, lysine hydrochloride, sodium benzoate, sucralose, and lactic acid to the material obtained in step (1) in sequence, and stir for 15 minutes until completely dissolved.

[0034] (3) Continue heating to make the temperature of the liquid medicine reach 105°C and keep it warm for 30 minutes, then close the steam valve to stop heating.

[0035] (4) Turn on the condensed water and continue to stir to cool down until th...

Embodiment 2

[0038] Present embodiment provides a kind of calcium zinc gluconate oral solution, and prescription is composed as follows:

[0039]

[0040] The preparation method of calcium zinc gluconate oral solution comprises the following steps:

[0041] (1) Add purified water of 90% of the prescription amount to the batching tank, turn on the stirring device and open the steam valve, heat to 85°C, maintain at 85°C, add the weighed calcium gluconate, stir for 15 minutes until completely dissolved .

[0042] (2) Maintain the heating temperature at 85°C, add zinc gluconate, lysine hydrochloride, sodium benzoate, sucralose, and lactic acid to the material obtained in step (1) in sequence, and stir for 15 minutes until completely dissolved.

[0043] (3) Continue heating to make the temperature of the liquid medicine reach 105°C and keep it warm for 30 minutes, then close the steam valve to stop heating.

[0044](4) Turn on the condensed water and continue to stir to cool down until the...

Embodiment 3

[0047] Present embodiment provides a kind of calcium zinc gluconate oral solution, and prescription is composed as follows:

[0048]

[0049] The preparation method of calcium zinc gluconate oral solution comprises the following steps:

[0050] (1) Add purified water of 90% of the prescription amount to the batching tank, turn on the stirring device and open the steam valve, heat to 85°C, maintain at 85°C, add the weighed calcium gluconate, stir for 15 minutes until completely dissolved .

[0051] (2) Maintain the heating temperature at 85°C, add zinc gluconate, lysine hydrochloride, sodium benzoate, sucralose, and lactic acid to the material obtained in step (1) in sequence, and stir for 15 minutes until completely dissolved.

[0052] (3) Continue heating to make the temperature of the liquid medicine reach 105°C and keep it warm for 30 minutes, then close the steam valve to stop heating.

[0053] (4) Turn on the condensed water and continue to stir to cool down until th...

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Abstract

The invention discloses a calcium zinc gluconate oral solution and a preparation method thereof. The calcium zinc gluconate oral solution is prepared from calcium gluconate, zinc gluconate, lysine hydrochloride, lactic acid, sucralose, sodium benzoate, juicy peach essence and purified water. The calcium zinc gluconate oral solution does not contain sucrose or aspartame, is good in taste, and has the advantages of good stability and simple preparation process.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a calcium zinc gluconate oral solution and a preparation method thereof. Background technique [0002] Calcium-zinc gluconate oral solution was originally a calcium-zinc compound product developed by Aonuo (China) Pharmaceutical Company. The main components are calcium gluconate, zinc gluconate and lysine hydrochloride. Diseases, including osteoporosis, tetany, osteodystrophy, rickets, calcium supplementation for pregnant women and lactating women, growth retardation in children, anorexia, recurrent oral ulcers, and acne. The calcium contained in the medicine and the calcium obtained in the food are provided to the normal physiological needs of the human body. Combined with lysine to nourish the bones to maintain healthy and tough bones, get rid of the misunderstanding of calcium deficiency and single calcium supplementation, and solve the problem of minerals,...

Claims

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Application Information

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IPC IPC(8): A61K31/315A61K31/191A61K31/198A61K9/08A61K47/26A61P3/02
CPCA61K9/0095A61K31/191A61K31/198A61K33/30A61K47/26A61P3/02A61K2300/00
Inventor 杨婵珍占晴谭银合王雪峰张龙辉杨观琼
Owner 广州汇元医药科技有限公司
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