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Preparation method of D-pantoic acid calcium

A technology of pantoic acid and pantolactone, which is applied in carboxylate preparation, organic chemical methods, organic chemistry, etc., can solve the problems of low content, research, and inability to judge the application direction, and achieve high purity and less impurities , The preparation method is simple and easy to implement

Inactive Publication Date: 2021-01-12
安徽泰格生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] In the synthesis of D-calcium pantothenate, the existence of D-calcium pantothenate was found from the mother liquor and the product, but because its content was too low, it could not be studied, and its application direction could not be judged, so it is necessary to Provide a kind of preparation method that can obtain high-quality calcium D-pantoate

Method used

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  • Preparation method of D-pantoic acid calcium

Examples

Experimental program
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Effect test

Embodiment 1

[0029] A kind of preparation method of calcium D-pantoate is as follows:

[0030] (1) In a clean 500mL single-necked bottle, add 100g of deionized water successively, and the specific rotation is +46°D-pantolactone 50g, stir and dissolve, then add 114g of 25wt% calcium hydroxide aqueous solution dropwise, at 60°C React for 1h to obtain a mixed solution containing calcium D-pantoate;

[0031] (2) The mixed solution containing D-calcium pantoate is cooled down to -5° C. for crystallization after stirring, then filtered and dried to obtain D-calcium pantoate.

Embodiment 2

[0033] A kind of preparation method of calcium D-pantoate is as follows:

[0034] (1) In a clean 500mL single-necked bottle, add 100g of deionized water successively, and the specific rotation is +46 ° D-pantoate lactone 50g, stir and dissolve, then add 114g of 25wt% calcium hydroxide aqueous solution dropwise, at 80°C React for 1h to obtain a mixed solution containing calcium D-pantoate;

[0035] (2) The mixed solution containing D-calcium pantoate is cooled down to -5° C. for crystallization after stirring, then filtered and dried to obtain D-calcium pantoate.

Embodiment 3

[0037] A kind of preparation method of calcium D-pantoate is as follows:

[0038] (1) In a clean 500mL single-necked bottle, add 100g of deionized water successively, and the specific rotation is +46 ° D-pantoate lactone 50g, stir and dissolve, then add 190g of 15wt% calcium hydroxide aqueous solution dropwise, at 80°C React for 3 hours to obtain a mixed solution containing calcium D-pantoate;

[0039] (2) The mixed solution containing D-calcium pantoate was cooled down to -5° C. for 6 hours to crystallize after stirring, then filtered and dried to obtain D-calcium pantoate.

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PUM

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Abstract

The invention provides a preparation method of D-pantoic acid calcium. The preparation method comprises a step of reacting D-pantolactone with calcium hydroxide to obtain a mixed solution containing D-pantoic acid calcium. The preparation method provided by the invention is simple and feasible, a solvent is safe and pollution-free, stable crystals can be formed under a low-temperature condition, and the obtained D-pantoic acid calcium crystals are non-sticky to the wall, non-caking, few in impurities and high in purity.

Description

technical field [0001] The invention belongs to the technical field of chemical production and relates to a preparation method of calcium D-pantoate. Background technique [0002] D-pantoate lactone is derived from the chiral resolution of DL-pantoate lactone. DL-pantoate lactone is an organic chemical. The D-pantoate lactone obtained by chiral resolution can be Synthesize D-panthenol for cosmetics, or D-panthenol ethyl ether, etc. The biggest use of D-pantothenic acid lactone is to synthesize D-calcium pantothenate. D-calcium pantothenate is also known as pantothenic acid, also known as vitamin B5. It is a water-soluble B vitamin, which is widely used in food, medicine and feed Additives etc. [0003] In the synthesis of D-calcium pantothenate, the existence of D-calcium pantothenate was found from the mother liquor and the product, but because its content was too low, it could not be studied, and its application direction could not be judged, so it is necessary to A pre...

Claims

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Application Information

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IPC IPC(8): C07C51/41C07C59/06
CPCC07C51/41C07B2200/07
Inventor 陈修王浩杜斌段小瑞汪洪湖
Owner 安徽泰格生物科技有限公司
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