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Preparation method of chromium propionate

A technology of chromium propionate and n-propionate, which is applied in the field of preparation of chromium propionate, can solve problems such as unfavorable industrial continuous production, large occupational health risks, and need for post-processing, so as to be beneficial to industrial continuous production and facilitate industrial production , the effect of convenient operation

Active Publication Date: 2021-01-12
KEMIN (CHINA) TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

This method uses a large amount of highly toxic carcinogenic hydrazine hydrate (hydrazine hydrate) as an initiator, which requires post-processing, resulting in a large amount of toxic waste liquid, and has a greater occupational health risk.
The patent (CN 110054559A) discloses a preparation method of chromium propionate, which promotes the reaction of basic chromium carbonate and chromium carbonate mixture through ultrasound, and the reaction time is long, which is not conducive to industrial continuous production

Method used

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  • Preparation method of chromium propionate

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025]Add n-propionic acid (1110g, 15mol), lysine (584g, 4mol), 15L water and 1L ethanol to the reaction kettle, stir until the mixture is uniform, add chromium oxide solid (456g, 3mol) to it, adjust the speed to 500r / min, heat to 70-80°C with stirring, and react until there is no solid residue. The reaction time is 2 hours.

[0026]After the reaction, it was dried under reduced pressure to obtain a crude product containing lysine. The yield was determined by measuring the content of chromium in the product, and the yield of chromium propionate was determined to be 98.7%.

Embodiment 2

[0028]Add n-propionic acid (1110g, 15mol), lysine (584g, 4mol), 15L of water to the reaction kettle, stir until the mixture is uniform, add chromium oxide solid (456g, 3mol) to it, adjust the speed to 500r / min and stir Heat to 70-80°C, and react until no solid remains. The reaction time is 3 hours.

[0029]After the reaction, the product was dried under reduced pressure to obtain a crude product containing lysine. The yield was determined by measuring the content of chromium in the product. The yield of chromium propionate was 87.8%.

Embodiment 3

[0031]The influence of different initiators on the preparation of chromium propionate:

[0032]Add n-propionic acid (1110g, 15mol), initiator 4mol, 15L water and 1L ethanol to the reaction kettle, stir until the mixture is uniform, add chromium oxide solid (456g, 3mol) to it, adjust the speed to 500r / min, and stir. Heat to 70-80°C and react until no solid remains.

[0033]After the reaction, the product was dried under reduced pressure to obtain a crude product containing the initiator. The yield was determined by measuring the content of chromium in the product.

[0034]The specific yield and reaction time are as follows:

[0035] Group Initiator Reaction time Yield 1Lysine 2h98.7％ 2Glutamine 4h78.6％ 3Asparagine 4h66.7％ 4Ethylenediamine 6h90.4％ 5Blank group 6h (with solid residue) 50.4％

[0036]It can be concluded from the above that, compared to adding glutamine, asparagine and ethylenediamine as initiators, the yield of adding lysine as initiator is higher, so using lysine as initiator is t...

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Abstract

The invention relates to the technical field of organic synthesis, in particular to a preparation method of chromium propionate, which comprises the following steps: S1, adding n-propionic acid, aminoacid, water and an organic solvent into a reaction kettle, and stirring to uniformly mix to obtain a mixture 1, S2, adding chromium oxide solid into the mixture 1 in S1 to obtain a mixture 2, S3, adjusting the rotating speed, stirring the mixture 2 in the step S2, and heating the reaction kettle to enable the mixture 2 to react until no solid residues exist, so as to obtain a product 1, and S4, drying the product 1 obtained in the step S3 under reduced pressure to obtain a lysine-containing crude product. The method is green, efficient, safe, environmentally friendly and beneficial to industrial preparation of chromium propionate.

Description

Technical field[0001]The invention relates to the technical field of organic synthesis, in particular to a preparation method of chromium propionate.Background technique[0002]For a long time, chromium compounds have been used in the printing and dyeing and leather industry, and are considered to be toxic and harmful elements and even carcinogens. It was not until 1954 that Curran discovered that the ability of rat liver to synthesize cholesterol and fatty acids was enhanced by chromium supplementation, suggesting that chromium may be an essential trace element for animals. In 1959, Schwarz and Mertz isolated chromium-containing glucose tolerance factor (GTF), proving that chromium is an element necessary for insulin to function during glucose metabolism, and that chromium is a necessary substance for insulin to promote fat synthesis. Currently, chromium is considered to be one of the essential trace elements for humans and animals.[0003]Studies have shown that the absorption rate of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C51/41C07C53/122
CPCC07C51/412C07C53/122
Inventor 唐卓刘永才黄生树李正彭青云
Owner KEMIN (CHINA) TECH CO LTD
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