Dihydromyricetin gastric floating pills and preparation method thereof
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A technology of dihydromyricetin and floating pills, applied in the field of medicine, can solve the problems of poor solubility, easy drug leakage, drug stability, low encapsulation rate, etc., and achieves the effects of expanding output, improving floating rate and simple process
Active Publication Date: 2021-01-22
SOUTHWEST MEDICAL UNIVERISTY
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[0006] Aiming at the problems of poor solubility, low encapsulation efficiency, easy drug leakage and low drug s...
Method used
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Embodiment 1-10
[0048] The preparation method of embodiment 1-10 is as follows:
[0049] Step 1: Add dihydromyricetin, 1-hexadecanol, hyaluronic acid, PVP-K30 and sodium bicarbonate into a marble mortar.
[0050] Step 2: Add purified water and grind thoroughly to form a paste mixture.
[0051] Step 3: Transfer the pasty mixture to the HK-93C high-performance pellet machine to make spherical pre-pellets with a diameter of about 3-8 mm.
[0052] Step 4: Freeze-dry the spherical pre-pellet for 12-36 hours to obtain the final product.
Embodiment 1
[0054] (1) Take 200 mg of dihydromyricetin, 90 mg of 1-hexadecanol, 130 mg of hyaluronic acid, 70 mg of PVP-K30, and 50 mg of sodium bicarbonate into a marble mortar.
[0055] (2) Add 225 μl of purified water, grind thoroughly to form a paste mixture.
[0056] (3) Transfer the pasty mixture to the HK-93C high-performance pellet machine to make spherical pre-pellets with a diameter of about 3-8 mm.
[0057] (4) The spherical pre-pellet is freeze-dried for 12-36 hours to obtain the final product.
Embodiment 2
[0059] (1) Take 200 mg of dihydromyricetin, 90 mg of 1-hexadecanol, 140 mg of hyaluronic acid, 80 mg of PVP-K30, and 50 mg of sodium bicarbonate into a marble mortar.
[0060] (2) Add 263 μl of purified water, grind thoroughly to form a paste mixture.
[0061] (3) Transfer the pasty mixture to the HK-93C high-performance pellet machine to make spherical pre-pellets with a diameter of about 3-8 mm.
[0062] (4) Freeze-drying the spherical pre-pellet for 12-36 hours to obtain the final product.
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Abstract
The invention belongs to the technical field of medicines, and particularly relates to dihydromyricetin gastric floating pills and a preparation method thereof. The invention aims to solve the problems of poor solubility, low encapsulation efficiency, easy medicine leakage and low medicine stability of dihydromyricetin preparations in the prior art. The dihydromyricetin gastric floating pills provided by the invention comprise the following components: dihydromyricetin, and 13-17 parts of hydrophilic gel. The invention also provides a preparation method of the dihydromyricetin gastric floatingpills and an application of the dihydromyricetin gastric floating pill to preparation of medicines. The dihydromyricetin gastric floating pills provided by the invention are suitable for administration of the dihydromyricetin, can improve the conditions of high-dose and high-frequency administration of the dihydromyricetin, and only need to be administrated once a day.
Description
technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a dihydromyricetin gastric floating pill and a preparation method thereof. Background technique [0002] Gastric floating preparations are based on the principle of a hydrodynamic balanced controlled release system, made of drugs, one or more hydrophilic gel skeleton materials and other auxiliary materials, and can exist in capsules, tablets or other forms. Tossunian and Sheth were the first to describe in detail the floating sustained-release preparations in the stomach, and called them "biologically effective preparations". In the early 1980s, Hofmann-La Roche first introduced two floating preparation varieties, Valrelease and ValiumCR, and then new HBS products came out continuously on the market. In recent decades, scientists have successively confirmed the advantages of intragastric floating sustained-release preparations to prolong the residence time of drugs ...
Claims
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Application Information
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