Cosmetic comprising phloretin derivative containing phloroglucinol groups and preparation method of phloretin derivative

A technology for phloretin and derivatives is applied in the field of cosmetics and preparations of phloretin derivatives, which can solve the problems of low skin absorption efficiency, poor water solubility of phloretin, limited application diversity of phloretin, and the like, and achieve excellent Antioxidative properties, improvement of water solubility and skin absorption efficiency, effect of securing antioxidative properties

Pending Publication Date: 2021-02-02
青岛姿之妍化妆品科技有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, gel preparations limit the application versatility of phloretin
[0007] At the same time, this method does not fundamentally solve the problems of poor water solubility and low skin absorption efficiency of phloretin

Method used

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  • Cosmetic comprising phloretin derivative containing phloroglucinol groups and preparation method of phloretin derivative
  • Cosmetic comprising phloretin derivative containing phloroglucinol groups and preparation method of phloretin derivative
  • Cosmetic comprising phloretin derivative containing phloroglucinol groups and preparation method of phloretin derivative

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preparation example Construction

[0027] (1), preparation of bromotetraacetylglucose

[0028] Add glucosamine to 3-5 times the molar amount of acetic anhydride, add 5-6 times the molar amount of triethylamine dropwise under ice-water bath conditions, add sufficient water to precipitate the product after reacting for 2 hours, filter and wash the filter cake with water After vacuum drying, aminotetraacetylglucose was obtained; the dried aminotetraacetylglucose was dissolved in dichloromethane, and hydrobromic acid of 2.5-4 times the molar amount of aminotetraacetylglucose was added dropwise at room temperature, wherein the hydrobromic acid was measured by mass Provide 30% hydrobromic acid acetic acid solution, react for 1.5-3 hours, pour into ice water, extract the water phase with dichloromethane, combine the organic phase, wash the organic phase quickly with saturated sodium bicarbonate solution and saturated saline respectively The pH value is 7, dried over anhydrous magnesium sulfate and filtered, and the fi...

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Abstract

The invention provides a preparation method of a phloretin derivative containing phloroglucinol groups. The phloretin derivative containing the phloroglucinol groups is phloretin modified by amino triacetyl glucoside. Hydroxyl in p-hydroxyphenylpropionic acid in raw materials for synthesizing the phloretin is modified and grafted in advance, and then a synthetic reaction is performed with phloroglucinol to obtain the corresponding phloretin derivative containing the phloroglucinol groups, namely the phloretin modified by the amino triacetyl glucoside. The derivative not only retains the oxidation resistance and inflammation resistance of the phloretin, but also has good water solubility and skin absorption efficiency, so that the obtained phloretin derivative can be widely applied to various forms of cosmetic products and has excellent oxidation resistance and inflammation resistance.

Description

technical field [0001] The invention relates to the field of cosmetics, in particular to a cosmetic comprising a phloretin derivative containing a phlorotriol group and a preparation method thereof. Background technique [0002] Cosmetics refer to products that are applied to the surface of the human body by smearing or other similar methods to achieve the effects of cleaning, maintaining, and beautifying the surface. At present, there are many kinds of cosmetics on the market, among which, the cosmetics for relieving skin inflammation, anti-oxidation and anti-aging are most popular among women. [0003] Phloretin, namely 2,4,6-trihydroxy-3-(4-hydroxyphenyl)propiophenone, is a natural flavonoid compound, mainly distributed in the pericarp and root bark of juicy fruits such as apples and pears, and various vegetable juices. The whitening, anti-acne, anti-oxidation, and anti-inflammatory effects of phloretin are attributed to the "2,4,6-trihydroxyl" group in the phloretin mo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H15/203C07H1/00A61K8/60A61P29/00A61Q19/00A61Q19/08
CPCA61K8/602A61Q19/00A61Q19/08A61P29/00C07H1/00C07H15/203
Inventor 蔺会杰
Owner 青岛姿之妍化妆品科技有限责任公司
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