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Bimetal covalent organic framework material and preparation method thereof and aptamer sensor

A covalent organic framework, bimetallic technology, used in the analysis of materials, material inspection products, material analysis by electromagnetic means, etc., can solve the problems of low sensitivity and low detection limit, and achieve the effect of large specific surface area

Active Publication Date: 2021-02-05
ZHENGZHOU UNIVERSITY OF LIGHT INDUSTRY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the existing TOB assay methods have the problems of low sensitivity and low detection limit.

Method used

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  • Bimetal covalent organic framework material and preparation method thereof and aptamer sensor
  • Bimetal covalent organic framework material and preparation method thereof and aptamer sensor
  • Bimetal covalent organic framework material and preparation method thereof and aptamer sensor

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preparation example Construction

[0069] The preparation of relevant solution in the embodiment: with 0.24gKH 2 PO 4 , 1.44gNa 2 HPO 4 12H 2 O, 0.20gKCl and 8.0gNaCl were mixed to prepare a phosphate buffer solution (PBS, 0.01M, pH 7.4). Dissolve 1.65g K in 1.0L PBS respectively 3 [Fe(CN) 6 ], 2.11gK 4 [Fe(CN) 6 ], 8.0g and 7.45gKCl to prepare the electrolyte for electrochemical experiments. Stock solutions of aptamers and TOB were prepared in PBS. All solutions were prepared immediately before each test and stored at 4°C until use.

[0070] 1. Specific examples of bimetallic covalent organic framework materials of the present invention

Embodiment 1

[0072] The bimetallic covalent organic framework material in this example, denoted as CoPc-TA-PTD(Ni), is a covalent organic framework body formed by a Schiff base condensation reaction between tetraaminocobalt phthalocyanine and PTD, and a metal-organic Coordinated forms of nickel ions complexed with PTD units on said covalent organic framework host, figure 1 The structural formula in is part of the compound, where -NH 2 Can further covalently react with carbonyl groups.

Embodiment 2

[0074] The bimetallic covalent organic framework material in this example, denoted as NiPc-TA-PTD(Co), is a covalent organic framework body formed by a Schiff base condensation reaction between tetraaminonickel phthalocyanine and PTD, and a metal-organic Coordinated forms of cobalt ions complexed with PTD units on the covalent organic framework host.

[0075] Two. Specific examples of the preparation method of the bimetallic covalent organic framework material of the present invention

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Abstract

The invention belongs to the technical field of composite functional materials, and particularly relates to a bimetal covalent organic framework material and a preparation method thereof and an aptamer sensor. The bimetal covalent organic framework material is a metal-covalent composite organic framework material, and comprises a covalent organic framework main body formed by carrying out a Schiffbase condensation reaction on tetraamino metal phthalocyanine and PTD, and metal ions compounded with a PTD unit on the covalent organic framework main body in a metal-organic coordination form, wherein the metal in the tetraamino metal phthalocyanine is selected from cobalt or nickel. The metal ions are introduced into porous COFs in a targeted manner to form metal covalent organic frameworks (MCOFs). The MCOFs can build a bridge between the MOFs and the COFs, so that the porosity, the stability, the crystallinity and the adjustability of the MOFs and the COFs can be balanced, and complementary characteristics are formed between the MOFs and the COFs.

Description

technical field [0001] The invention belongs to the technical field of composite functional materials, and in particular relates to a bimetallic covalent organic framework material, a preparation method thereof, and an aptamer sensor. Background technique [0002] Antibiotics have been widely used in the food industry, human medicine and veterinary medicine because of their low cost and highly effective pharmacokinetic properties. However, excessive use of antibiotics can cause bacterial resistance, damage the intestinal flora and other problems, thereby destroying the human immune system. The abuse of antibiotics will not only cause very serious environmental pollution, but also accumulate in food, posing a serious threat to human health. [0003] Tobramycin (TOB) is a broad-spectrum aminoglycoside antibiotic produced by Streptomyces flavus. TOB has good water solubility, stability, and broad-spectrum antibacterial properties, and has certain bactericidal effects on vario...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G83/00G01N27/327G01N33/53
CPCC08G83/008G01N27/3278G01N33/5308
Inventor 杜淼王明花朱磊张治红栗俊广白艳红
Owner ZHENGZHOU UNIVERSITY OF LIGHT INDUSTRY
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