Method for detecting content of diosmin sodium sulfonate

A technology of diosmin sodium sulfonate and a detection method, which is applied in the field of chemical analysis, can solve the problems of long analysis time, unfavorable product quality, complicated processing, etc., achieve reliable analysis results, simple and fast processing steps, and improve detection efficiency Effect

Active Publication Date: 2021-02-05
佛山市南海北沙制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the content detection method of diosmin sodium sulfonate adopts HPLC method to detect, and its sample pretreatment is more loaded down with trivial details, and has the shortcoming that analysis time is long, is unfavorable for controlling and evaluating the quality situation of this product; For existing in the prior art Problem, the present invention provides a method for measuring the content of diosmin sodium sulfonate

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] The content detection method of diosmin sodium sulfonate in the present embodiment comprises the following steps:

[0025] The mensuration of total sodium sulfate content comprises the following steps:

[0026] S1-a. Weigh 1.0g sample, accurately weigh it, put it into a 100ml beaker, add 20ml nitric acid for hydrolysis for 15 minutes.

[0027] S1-b. After adding 20ml of 10% barium chloride solution, perform ultrasonic vibration for 5 minutes.

[0028] S1-c. Use the sand core funnel after constant weight to filter, and wash the filter residue in the sand core funnel with 90ml of water three times;

[0029] S1-d. Dry the funnel at 105°C for 1 to 2 hours, and weigh it after cooling;

[0030] S1-e. Calculate the total sodium sulfate content: S1=

[0031] Among them, m1 is the weight of the sand core funnel and the sample after drying in step S1-d; m2 is the weight after the constant weight of the sand core funnel in step S1-c; m3 is the weight of the sample in step S1-...

Embodiment 2

[0041] The content detection method of diosmin sodium sulfonate in the present embodiment comprises the following steps:

[0042] The mensuration of total sodium sulfate content comprises the following steps:

[0043] S1-a. Weigh 2.0g of sample, accurately weigh it, put it into a 100ml beaker, add 30ml of nitric acid to hydrolyze for 20 minutes.

[0044] S1-b. After adding 30ml of 10% barium chloride solution, perform ultrasonic vibration for 10 minutes.

[0045] S1-c. Use the sand core funnel after constant weight to filter, and wash the filter residue in the sand core funnel three times with 180ml of water;

[0046] S1-d. Dry the funnel at 105°C for 1 to 2 hours, and weigh it after cooling;

[0047] S1-e. Calculate the total sodium sulfate content: S1=

[0048] Among them, m1 is the weight of the sand core funnel and the sample after drying in step S1-d; m2 is the weight after the constant weight of the sand core funnel in step S1-c; m3 is the weight of the sample in st...

Embodiment 3

[0058] The content detection method of diosmin sodium sulfonate in the present embodiment comprises the following steps:

[0059] The mensuration of total sodium sulfate content comprises the following steps:

[0060] S1-a. Weigh 1.0gg sample, weigh it accurately, put it into a 100ml beaker, add 25ml of nitric acid to hydrolyze for 18 minutes.

[0061] S1-b. After adding 25ml of 10% barium chloride solution, perform ultrasonic vibration for 8 minutes.

[0062]S1-c. Use the sand core funnel after constant weight to filter, and wash the filter residue in the sand core funnel three times with 120ml of water;

[0063] S1-d. Dry the funnel at 105°C for 1 to 2 hours, and weigh it after cooling;

[0064] S1-e. Calculate the total sodium sulfate content: S1=

[0065] Among them, m1 is the weight of the sand core funnel and the sample after drying in step S1-d; m2 is the weight after the constant weight of the sand core funnel in step S1-c; m3 is the weight of the sample in step S...

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Abstract

The invention discloses a method for detecting the content of diosmin sodium sulfonate, which comprises the following steps: measuring the content of total sodium sulfate and sodium protosulfate, andcalculating the content of diosmin sodium sulfonate according to a formula. Compared with the traditional HPLC detection method, the determination method provided by the invention has the advantages that the treatment steps are simple and quick, the consumed time is shorter, the detection efficiency is favorably improved, and the analysis result is reliable. Meanwhile, a chromatographic analyzer is not needed for analysis in the detection process, the equipment threshold required by detection can be reduced, and application and popularization are facilitated.

Description

technical field [0001] The invention relates to the field of chemical analysis, in particular to a method for detecting the content of diosmin sodium sulfonate. Background technique [0002] Sodium diosmin sulfonate, the chemical name is diosmin sodium heptasulfate, and its chemical formula is C 28 h 25 o 36 S 7 Na 7 , with a molecular weight of 1322.87, is yellow or khaki powder, easily soluble in water, slightly soluble in acetone, and almost insoluble in ethanol. It is a flavonoid compound that can enhance venous tension drugs and blood vessel protection agents. Various symptoms associated with lymphatic insufficiency, treatment of various symptoms of acute hemorrhoid attacks. [0003] At the same time, diosmin sodium sulfonate is an important intermediate of dosemamate. Dosemamate is a gastric mucosal protective drug, a safe local cell protective agent, and has a good curative effect on gastrointestinal ulcers. Dosmarate is similar to sucralfate in its ability to ...

Claims

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Application Information

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IPC IPC(8): G01N5/00G01N33/15
CPCG01N5/00G01N33/15
Inventor 黄升刘明威邱伟杰黎小雄
Owner 佛山市南海北沙制药有限公司
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