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A kind of content detection method of sodium diosmin sulfonate

A technology of diosmin sodium sulfonate and a detection method, which is applied in the field of chemical analysis, can solve problems such as unfavorable product quality, cumbersome processing, and long analysis time, and achieve simple and fast processing steps, improved detection efficiency, and reliable analysis results Effect

Active Publication Date: 2022-07-15
佛山市南海北沙制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the content detection method of diosmin sodium sulfonate adopts HPLC method to detect, and its sample pretreatment is more loaded down with trivial details, and has the shortcoming that analysis time is long, is unfavorable for controlling and evaluating the quality situation of this product; For existing in the prior art Problem, the present invention provides a method for measuring the content of diosmin sodium sulfonate

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] The content detection method of sodium diosmin sulfonate in the present embodiment, comprises the following steps:

[0025] The determination of total sodium sulfate content includes the following steps:

[0026] S1-a. Weigh 1.0g sample, accurately weigh it, add it to a 100ml beaker, add 20ml of nitric acid to hydrolyze for 15 minutes.

[0027] S1-b. Add 20 ml of 10% barium chloride solution and perform ultrasonic vibration for 5 minutes.

[0028] S1-c. Use a sand core funnel with constant weight to filter, and wash the filter residue in the sand core funnel three times with 90ml of water;

[0029] S1-d. The funnel is dried at 105°C for 1-2 hours, and weighed after cooling;

[0030] S1-e. Calculate the total sodium sulfate content: S1=

[0031] Wherein, m1 is the weight of the sand core funnel and the sample after drying in step S1-d; m2 is the weight of the sand core funnel after constant weight in step S1-c; m3 is the weighing sample amount of the sample in step ...

Embodiment 2

[0041] The content detection method of sodium diosmin sulfonate in the present embodiment, comprises the following steps:

[0042] The determination of total sodium sulfate content includes the following steps:

[0043] S1-a. Weigh 2.0g of the sample, accurately weigh it, add it to a 100ml beaker, add 30ml of nitric acid to hydrolyze for 20 minutes.

[0044] S1-b. Add 30 ml of 10% barium chloride solution and perform ultrasonic vibration for 10 minutes.

[0045] S1-c. Use a sand core funnel with constant weight to filter, and wash the filter residue in the sand core funnel three times with 180ml of water;

[0046] S1-d. The funnel is dried at 105°C for 1-2 hours, and weighed after cooling;

[0047] S1-e. Calculate the total sodium sulfate content: S1=

[0048] Wherein, m1 is the weight of the sand core funnel and the sample after drying in step S1-d; m2 is the weight of the sand core funnel after constant weight in step S1-c; m3 is the weighing sample amount of the sample...

Embodiment 3

[0058] The content detection method of sodium diosmin sulfonate in the present embodiment, comprises the following steps:

[0059] The determination of total sodium sulfate content includes the following steps:

[0060] S1-a. Weigh 1.0gg sample, accurately weigh it, add it to a 100ml beaker, add 25ml of nitric acid to hydrolyze for 18 minutes.

[0061] S1-b. Add 25 ml of 10% barium chloride solution and perform ultrasonic vibration for 8 minutes.

[0062]S1-c. Use a sand core funnel with constant weight to filter, and wash the filter residue in the sand core funnel three times with 120ml of water;

[0063] S1-d. The funnel is dried at 105°C for 1-2 hours, and weighed after cooling;

[0064] S1-e. Calculate the total sodium sulfate content: S1=

[0065] Wherein, m1 is the weight of the sand core funnel and the sample after drying in step S1-d; m2 is the weight of the sand core funnel after constant weight in step S1-c; m3 is the weighing sample amount of the sample in step...

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Abstract

The invention discloses a method for detecting the content of sodium diosmin sulfonate. The content of total sodium sulfate and sodium orthosulfate is measured first, and then the content of sodium diosmin sulfonate is calculated according to a formula. Compared with the traditional HPLC detection method, the determination method adopted in the present invention has the advantages of simple and quick processing steps and shorter time, which is beneficial to improve the detection efficiency and the analysis result is reliable. At the same time, the detection process does not need to use a chromatographic analyzer for analysis, which can reduce the threshold of equipment required for detection and facilitate popularization and use.

Description

technical field [0001] The invention relates to the field of chemical analysis, in particular to a method for detecting the content of sodium diosmin sulfonate. Background technique [0002] Sodium diosmin sulfonate, chemical name is sodium geraninoside heptasulphate, its chemical formula is C 28 H 25 O 36 S 7 Na 7 , the molecular weight is 1322.87, it is yellow or khaki powder, easily soluble in water, slightly soluble in acetone, and almost insoluble in ethanol. Various symptoms related to lymphatic insufficiency, treatment of various symptoms of acute hemorrhoidal attack. [0003] At the same time, sodium diosmin sulfonate is an important intermediate of dosima ester. Dosima ester is a gastric mucosal protective drug, which is a safe local cell protective agent, and has a good effect on gastrointestinal ulcers. The consumption ability of dosima ester to acid substances is similar to that of sucralfate. In gastric juice, dosima ester forms a protective film coverin...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N5/00G01N33/15
CPCG01N5/00G01N33/15
Inventor 黄升刘明威邱伟杰黎小雄
Owner 佛山市南海北沙制药有限公司
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