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A kind of preparation method of ceftiofur microspheres

A technology of ceftiofur and microspheres, which is applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, etc., can solve the problems of unfavorable insoluble drug release and strong hydrophobicity, and achieve good Biocompatibility, high drug loading, and high stability effects

Active Publication Date: 2022-05-31
山东华辰制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

[0005] PLA microspheres are not conducive to the release of insoluble drugs due to their strong hydrophobicity

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] The organic solvent is ethyl acetate, dichloromethane mixed solution and methanol, and the volume percent is 80:20.

Embodiment 2

[0031] The organic solvent is ethyl acetate, dichloromethane mixed solution and methanol, and the volume percent is 80:20.

Embodiment 3

[0036] The organic solvent is ethyl acetate, dichloromethane mixed solution and methanol, and the volume percent is 80:20.

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PUM

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Abstract

The invention discloses a preparation method of ceftiofur microspheres, which relates to the field of veterinary medicine and includes the following steps: Step 1. Dissolving polylactic acid-polyethylene glycol block copolymer as a carrier material in an organic solvent; Step 2. Add ceftiofur and stir and mix to prepare a dispersed phase; Step 3. Add the above dispersed phase into water, add an emulsifier, and emulsification with magnetic stirring to obtain an emulsion; Step 4. Quickly stir the emulsion for a period of time T1, replenish water, and continue stirring for a period of time T2 until the organic solvent is completely evaporated; step 5. After centrifugation, washing, collection, and vacuum drying, ceftiofur microspheres are obtained. The ceftiofur sustained-release microspheres of the present invention make the drug more uniformly dispersed in the carrier material, and have high drug loading. The drug has a stronger sustained-release effect and lasts longer.

Description

A kind of preparation method of ceftiofur microspheres technical field The present invention relates to field of veterinary medicine, especially relate to a kind of preparation method of ceftiofur microspheres. Background technique Ceftiofur is the special 3rd generation cephalosporin for animals, because it has strong antibacterial activity, wide antibacterial spectrum, pharmacokinetics Due to its excellent mechanical properties, small toxic and side effects, and low residues, it is widely used all over the world. At present, domestic listed ceftiofur related preparations mainly contain ceftiofur injection, ceftiofur sodium powder injection ceftiofur hydrochloride injection, etc., due to poor oral absorption of ceftiofur, the main method of use is injection. The effective therapeutic concentration requires multiple injections, usually once a day for 3 to 5 days. Big inconvenience. In order to reduce the stress response of animals caused by frequent injection of c...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/16A61K31/546A61K47/34A61P31/04A61P11/00
CPCA61K9/1641A61K9/1694A61K31/546A61P31/04
Inventor 王建国王少娟刘海王春梅周愉淇匡宝晓
Owner 山东华辰制药有限公司
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