Nosiheptide flavored chewable tablets, preparation method thereof and application of nosiheptide-flavored chewable tablets in clostridium welchii disease

A technology of nosiheptide and chewable tablets, which is applied in the field of nosiheptide flavored chewable tablets and its preparation, which can solve the problems of the stability of main ingredients, disintegration of tablets, and increased dissolution, so as to improve solubility and bioavailability, Effects of improving palatability and improving stability

Active Publication Date: 2021-02-12
ZHEJIANG ESIGMA BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But this makes the disintegration of tablet, stripping increase difficulty; A fermented antibiotic, long-term storage in the environment will easily cause degradation. Therefore, it is also very important to solve the stability problem of nosiheptide chewable tablets

Method used

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  • Nosiheptide flavored chewable tablets, preparation method thereof and application of nosiheptide-flavored chewable tablets in clostridium welchii disease
  • Nosiheptide flavored chewable tablets, preparation method thereof and application of nosiheptide-flavored chewable tablets in clostridium welchii disease
  • Nosiheptide flavored chewable tablets, preparation method thereof and application of nosiheptide-flavored chewable tablets in clostridium welchii disease

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0041] A preparation method of nosiheptide flavor chewable tablets, comprising the steps of:

[0042] Step 1, prepare materials according to the formula, the formula includes: nosiheptide 1%-10%, acidulant 5%, diluent 30%-40%, binder 1%, filler 30%-40%, Disintegrant 2%-10%, flavoring agent 5%-20%, coating agent 1%-5%;

[0043] Step 2, crushing Nosiheptide, diluent, filler, disintegrating agent, binder, and flavoring agent, and then sieving and filtering respectively; as a preferred method, 80-mesh sieve is used for sieving.

[0044] Step 3: Mix nosiheptide, diluent, and disintegrant to obtain a mixture, prepare a binder and an acidifier together to obtain a binding liquid, mix the mixture and the binding liquid to form a soft material, and sieve to form granules. After drying at 40°C-45°C, sieve to obtain granules; as a preferred method, pass through a 40-mesh sieve to make granules, dry at 40°C-45°C, and then pass through 40-mesh and 65-mesh sieves for granulation, remove C...

Embodiment 1

[0056] This example prepares nosiheptide flavored chewable tablets of the present invention, which are made of raw materials with mass percentages as in Table 1:

[0057] Table 1 Each component and its content of nosiheptide flavor chewable tablet of the present invention

[0058]

[0059] Preparation method: pass nosiheptide, microcrystalline cellulose, corn starch, cross-linked polyvinylpyrrolidone and artificial beef essence through 80-mesh sieve respectively, and take nosiheptide, microcrystalline cellulose, cross-linked Polyvinylpyrrolidone, mixed evenly, added the previously prepared binding solution A, made soft material, passed through a 40 mesh sieve to granulate, dried at 45°C, passed through a 40 mesh and 65 mesh sieve for granulation, and removed coarse particles and Fine powder to obtain granules; the above-mentioned granules are fluidized bed coated with the coating solution prepared in advance, and the weight of the coating is increased by 5%, and then passed...

Embodiment 2

[0061] This embodiment prepares nosiheptide flavored chewable tablets of the present invention, which are made of raw materials with mass percentages as in Table 2:

[0062] Table 2 each component and its content of nosiheptide flavor chewable tablet of the present invention

[0063]

[0064] Preparation method: pass nosiheptide, microcrystalline cellulose, corn starch, cross-linked polyvinylpyrrolidone and artificial beef essence through 80-mesh sieve respectively, and take nosiheptide, microcrystalline cellulose, cross-linked Polyvinylpyrrolidone, mixed evenly, added the previously prepared binding solution A, made soft material, passed through a 40 mesh sieve to granulate, dried at 45°C, passed through a 40 mesh and 65 mesh sieve for granulation, and removed coarse particles and Fine powder to obtain granules; the above-mentioned granules are fluidized bed coated with the coating solution prepared in advance, and the weight of the coating is increased by 5%, and then pas...

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Abstract

The invention discloses nosiheptide flavored chewable tablets, a preparation method thereof and application of the nosiheptide flavored chewable tablets in clostridium welchii disease. The nosiheptideflavored chewable tablets are prepared from, by mass, 1%-10% of nosiheptide, 5% of acidifier, 30%-40% of diluent, 1% of a binder, 30%-40% of a filler, 2%-10% of a disintegrating agent, 5%-20% of a corrigent and 1%-5% of a coating agent. According to the invention, the acidifier is added into the formula to prepare the acidic binder, so that the stability of the main component of nosiheptide is greatly improved, the production of the nosiheptide chewable tablet with controllable quality is facilitated, and the validity period of the product can be obviously prolonged; a carboxymethyl ethyl cellulose aqueous system is used for coating, so that the solubility and bioavailability of nosiheptide are improved; animal tests show that the nosiheptide flavored chewable tablets produced by the invention can be used for effectively treating clostridium welchii disease of dogs.

Description

technical field [0001] The invention relates to the field of medicine, in particular to nosiheptide flavored chewable tablet and its preparation method and its application on clostridium canis. Background technique [0002] Clostridium welchii can appear in human and animal feces, soil, water, and dust, and is a typical conditional pathogen; most of the disease is prevalent in late autumn and early winter, especially in abnormal climate change, rainy and humid conditions; this disease is not All age and gender varieties can be affected. Clostridium welchii can infect a variety of animals, such as acute enteritis in dogs, enteritis in cattle, necrotic enteritis in piglets, enteritis in rabbits, etc. In recent years, domestic animal mortalities are mostly related to this bacterium, with acute onset, short course, and no early stage. Symptoms and sudden death, and the mortality rate is extremely high. [0003] Acute death of dogs caused by Clostridioides welchii disease in do...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/36A61K9/32A61K38/05A61K47/02A61K47/12A61K47/38A61K47/32A61K47/40A61K47/36A61P31/04
CPCA61K38/05A61K9/0056A61K9/2054A61K9/2059A61K9/2013A61K9/2009A61K9/205A61K9/2866A61K9/284A61P31/04Y02A50/30
Inventor 陈贵才王贤玉张丽佳徐天华左纯子徐栋刘柳张小朋
Owner ZHEJIANG ESIGMA BIOTECH CO LTD
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