Method for continuously producing monochloroacetone by micro-droplet reactor

Abstract

The invention discloses a method for continuously producing high-purity monochloroacetone by using a micro-droplet reactor. The method comprises the following steps: reacting acetone in a continuous phase with Cl2 in a dispersion phase by using a hydrochloric acid aqueous solution containing chlorine with a certain concentration as the dispersion phase and a cyclohexane solution containing acetoneas the continuous phase, and rectifying the obtained reaction product to obtain the high-purity monochloroacetone. According to the invention, an HCl solution containing Cl2 is sheared into micro-droplets by the continuous phase in the micro-channel, and the micro-droplets are surrounded by the continuous phase, so that corrosion of the HCl solution to equipment is avoided; and excessive acetonein the continuous phase reacts with Cl2 in the liquid drop on a phase interface to generate monochloroacetone, then monochloroacetone is diffused to a continuous phase main body, and Cl2 is insolublein cyclohexane, so that Cl2 can be effectively prevented from further reacting with monochloroacetone to obtain a by-product; and the high-purity monochloroacetone is continuously and efficiently produced by adopting the micro-droplet reactor, so that the generation of byproducts is greatly reduced, and the process is easy to control.

Description

technical field [0001] The invention belongs to the technical field of organic synthesis technology, in particular to a method for continuously producing high-purity monochloroacetone in a microdroplet reactor. Background technique [0002] Monochloroacetone is an important organic synthesis intermediate, used in the production of dyes, pesticides, drugs, fragrances, antioxidants, desiccants, vinyl photosensitive resins, color motion picture film coupling agents, etc. In the pharmaceutical industry, it is mainly used to produce antibiotics, pain relievers, etc., especially ofloxacin, a new quinolone antibacterial drug. With the rapid increase in the market demand for ofloxacin, the demand for the raw material monochloroacetone also increases rapidly. In the production of pharmaceuticals, the requirements for the purity of monochloroacetone are very high. Monochloroacetone can be obtained from acetone and Cl 2 reaction prepared. Since the hydrogen atom on the α carbon in ...

AI Technical Summary

Problems solved by technology

Although this process can obtain monochloroacetone, there are many problems

First, batch operation severely reduces yield

The second, the yield of dichloroacetone is higher than 10%, not only has caused the waste of raw material, more importantly is the difficulty of product purification, and the monochloroacetone purity that obtains is not high

Third, acetone requires a large excess, and the recovery of acetone requires high energy consumption

Mesityl oxide and monochloroacetone are difficult to separate mixtures, so there are still problems of low product purity and high energy consumption of the system

[0004] The monochloroacetone production process reported above all can obtain monochloroacetone, but the common defect of these processes is that the purity is not high

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